• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

CD274 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9246643

Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:28813410). Through a yet unknown… More details

$475 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD274, Polyclonal Antibody
Full Product Name
CD274 Polyclonal Antibody
Product Gene Name
anti-CD274 antibody
Product Synonym Names
Programmed cell death 1 ligand 1 (PD-L1)(PDCD1 ligand 1)(Programmed death ligand 1)(B7 homolog 1)(B7-H1)(CD antigen CD274)
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
33,275 Da
OMIM
605402
3D Structure
ModBase 3D Structure for Q9NZQ7
Applications Tested/Suitable for anti-CD274 antibody
Immunohistochemistry-Paraffin (IHC-P)

Immunohistochemistry (IHC) of anti-CD274 antibody

Dilution: IHC-p 1:50-200, ELISA 1:10000-20000
Rabbit Anti-CD274 Polyclonal Antibody – Cat# MBS9246643

Immunohistochemistry (IHC)-Paraffin of anti-CD274 antibody

Dilution: IHC-p 1:50-200, ELISA 1:10000-20000
Rabbit Anti-CD274 Polyclonal Antibody, Immunohistochemistry (IHC)-Paraffin – Cat# MBS9246643

Other Notes

Small volumes of anti-CD274 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD274 purchase

MBS9246643 is an antibody targeting CD274. Also known as CD274 Polyclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD274. It may not necessarily be applicable to this product.

NCBI GI #
390979639
NCBI GeneID
29126
NCBI Accession #
NP_001254635.1
UniProt Primary Accession #
Q9NZQ7
UniProt Secondary Accession #
Q14CJ2; Q2V8D5; Q66RK1; Q6WEX4; Q9NUZ5; B2RBA2; B4DU27
UniProt Related Accession #
Q9NZQ7
GenBank Nucleotide #
NM_001267706.1
NCBI Official Full Name
programmed cell death 1 ligand 1 isoform b
NCBI Official Synonym Full Names
CD274 molecule
NCBI Official Symbol
CD274
NCBI Official Synonym Symbols
B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1
UniProt Protein Name
Programmed cell death 1 ligand 1
UniProt Synonym Protein Names
B7 homolog 1
Protein Family
Programmed cell death
UniProt Gene Name
CD274
UniProt Synonym Gene Names
B7H1; PDCD1L1; PDCD1LG1; PDL1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1; B7-H1
UniProt Entry Name
PD1L1_HUMAN
NCBI Protein Information
programmed cell death 1 ligand 1; B7 homolog 1; CD274 antigen; PDCD1 ligand 1; programmed death ligand 1

UniProt Comments for CD274

CD274: Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 9p24

Cellular Component: plasma membrane; integral to membrane; endomembrane system; external side of plasma membrane

Molecular Function: protein binding

Biological Process: regulation of activated T cell proliferation; cell surface receptor linked signal transduction; negative regulation of interleukin-10 production; negative regulation of interferon-gamma production; negative regulation of activated T cell proliferation; T cell costimulation; immune response; positive regulation of T cell proliferation; signal transduction
Show more

Research Articles on CD274

1. Upregulation of B7-H1 in gastric cancer tissue correlated with disease progression and prognosis of gastric cancer patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD274 antibody

 Reference Product  PubMed Publications
 CD80 antibody  >381 publications with CD274 and CD80
 PDCD1 antibody  >300 publications with CD274 and PDCD1
 STAT1 antibody  >10 publications with CD274 and STAT1
 PTEN antibody  >7 publications with CD274 and PTEN

Pathways associated with anti-CD274 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 PD-1 Signaling Pathway antibodies  PD-1 Signaling Pathway Diagram

Diseases associated with anti-CD274 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >328 publications with CD274 and Neoplasms
 Inflammation Antibodies  >102 publications with CD274 and Inflammation
 Liver Diseases Antibodies  >83 publications with CD274 and Liver Diseases
 Necrosis Antibodies  >70 publications with CD274 and Necrosis
 Nervous System Diseases Antibodies  >68 publications with CD274 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >60 publications with CD274 and Neoplasms, Experimental
 Adenocarcinoma Antibodies  >58 publications with CD274 and Adenocarcinoma
 Kidney Diseases Antibodies  >41 publications with CD274 and Kidney Diseases
 Lung Diseases Antibodies  >38 publications with CD274 and Lung Diseases
 Lung Neoplasms Antibodies  >33 publications with CD274 and Lung Neoplasms

Organs/Tissues associated with anti-CD274 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >725 publications with CD274 and Blood
 Lymph Node Antibodies  >74 publications with CD274 and Lymph Node
 Lung Antibodies  >62 publications with CD274 and Lung
 Bone Antibodies  >55 publications with CD274 and Bone
 Skin Antibodies  >44 publications with CD274 and Skin
 Brain Antibodies  >31 publications with CD274 and Brain
 Pancreas Antibodies  >26 publications with CD274 and Pancreas
 Placenta Antibodies  >17 publications with CD274 and Placenta
 Stomach Antibodies  >12 publications with CD274 and Stomach
 Mouth Antibodies  >9 publications with CD274 and Mouth
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000