Rabbit Anti-CD3EAP Polyclonal Antibody – Cat# MBS6283183

CD3EAP Antibody – Rabbit Polyclonal

Name: CD3EAP Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6283183
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6283183

CD3EAP is a DNA dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. It is a component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in… More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD3EAP, Polyclonal Antibody

Full Product Name

CD3EAP, NT (DNA-directed RNA polymerase I subunit RPA34, RNA polymerase I-associated factor PAF49, Anti-sense to ERCC-1 protein, ASE-1, CD3-epsilon-associated protein, CD3E-associated protein, CAST, A34.5, PAF49, CAST, ASE1, CD3EAP) (Biotin)

Product Gene Name

anti-CD3EAP antibody

Product Synonym Names

DNA-directed RNA polymerase I subunit RPA34; RNA polymerase I-associated factor PAF49; Anti-sense to ERCC-1 protein; ASE-1; CD3-epsilon-associated protein; CD3E-associated protein; CAST; A34.5; PAF49; CAST; ASE1; CD3EAP

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

54,986 Da

Chromosome Location

Chromosome: 19; NC_000019.9 (45909467..45914024). Location: 19q13.3

OMIM

107325

3D Structure

ModBase 3D Structure for O15446

Immunogen

CD3EAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human CD3EAP.

Conjugate

Biotin

Note

Preservative Free

Product Categories/Family for anti-CD3EAP antibody

Antibodies; DNA Replication; Repair

Applications Tested/Suitable for anti-CD3EAP antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-CD3EAP antibody

WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-CD3EAP antibody

Yamazaki, T., et.al., J. Biol. Chem. 274 (26), 18173-18180 (1999). Whitehead, C.M., et.al., Chromosoma 106 (8), 493-502 (1997).

Other Notes

Small volumes of anti-CD3EAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD3EAP purchase

MBS6283183 is an antibody targeting CD3EAP. Also known as CD3EAP, NT (DNA-directed RNA polymerase I subunit RPA34, RNA polymerase I-associated factor PAF49, Anti-sense to ERCC-1 protein, ASE-1, CD3-epsilon-associated protein, CD3E-associated protein, CAST, A34.5, PAF49, CAST, ASE1, CD3EAP) (Biotin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD3EAP. It may not necessarily be applicable to this product.

NCBI GI #

6912246

NCBI GeneID

10849

NCBI Accession #

NP_036231.1

UniProt Primary Accession #

O15446

UniProt Secondary Accession #

Q32N11; Q7Z5U2; Q9UPF6

UniProt Related Accession #

O15446

GenBank Nucleotide #

NM_012099.1

NCBI Official Full Name

DNA-directed RNA polymerase I subunit RPA34

NCBI Official Synonym Full Names

CD3e molecule, epsilon associated protein

NCBI Official Symbol

CD3EAP

NCBI Official Synonym Symbols

ASE1; CAST; ASE-1; PAF49

UniProt Protein Name

DNA-directed RNA polymerase I subunit RPA34

UniProt Synonym Protein Names

A34.5; Antisense to ERCC-1 protein; ASE-1; CD3-epsilon-associated protein; CAST; CD3E-associated protein; RNA polymerase I-associated factor PAF49

UniProt Gene Name

CD3EAP

UniProt Synonym Gene Names

ASE1; CAST; PAF49; ASE-1; CAST

UniProt Entry Name

RPA34_HUMAN

NCBI Protein Information

DNA-directed RNA polymerase I subunit RPA34; A34.5; antisense to ERCC 1; CD3E-associated protein; antisense to ERCC-1 protein; CD3 epsilon associated protein; CD3-epsilon-associated protein; RNA polymerase I-associated factor PAF49; CD3e antigen, epsilon

UniProt Comments for CD3EAP

ASE-1: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation. Belongs to the eukaryotic RPA34 RNA polymerase subunit family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleolus; Transcription initiation complex

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleolus; RNA polymerase I transcription factor complex; chromosome; nucleus; DNA-directed RNA polymerase I complex

Molecular Function: DNA-directed RNA polymerase activity

Biological Process: negative regulation of gene expression, epigenetic; RNA elongation from RNA polymerase I promoter; transcription from RNA polymerase I promoter; gene expression; transcription initiation from RNA polymerase I promoter; termination of RNA polymerase I transcription; regulation of gene expression, epigenetic; transmembrane receptor protein tyrosine kinase signaling pathway; rRNA transcription

Research Articles on CD3EAP

1. variant alleles of PPP1R13L rs1970764 and CD3EAP rs967591 may contribute to risk factors of lung cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD3EAP antibody

Reference Product	PubMed Publications
CD3E antibody	>1 publications with CD3EAP and CD3E

Pathways associated with anti-CD3EAP antibody

Products by Pathway	Pathway Diagram
TNF-alpha/NF-kB Signaling Pathway antibodies	TNF-alpha/NF-kB Signaling Pathway Diagram

Diseases associated with anti-CD3EAP antibody

Disease Name	Pubmed Publications
Lung Neoplasms Antibodies	>3 publications with CD3EAP and Lung Neoplasms
Lung Diseases Antibodies	>3 publications with CD3EAP and Lung Diseases
Cardiovascular Diseases Antibodies	>3 publications with CD3EAP and Cardiovascular Diseases
Skin Neoplasms Antibodies	>1 publications with CD3EAP and Skin Neoplasms
Inflammation Antibodies	>1 publications with CD3EAP and Inflammation

Organs/Tissues associated with anti-CD3EAP antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>5 publications with CD3EAP and Lung
Bone Antibodies	>2 publications with CD3EAP and Bone
Skin Antibodies	>2 publications with CD3EAP and Skin
Brain Antibodies	>2 publications with CD3EAP and Brain
Vascular Antibodies	>1 publications with CD3EAP and Vascular
Pancreas Antibodies	>1 publications with CD3EAP and Pancreas