CD44 Antibody – Rabbit Polyclonal

CD44 is a type I transmembrane glycoprotein that mediates cellcell and cellmatrix interaction through its affinity for hyaluronic acid (HA) and possibly through other parts of the extracellular matrix (ECM). CD44 is highly polymorphic, possesses a number of alternative splice variants and undergoes extensive posttranslational modifications (1,2). Increased surface levels of CD44 are characteristic of T cell activation, and expression of the protein is upregulated during the inflammatory response. Interactions between CD44 and HER2 have been linked to an increase in ovarian carcinoma cell growth (1-3). CD44 interacts with ezrin, radixin and moesin (ERM), linking the actin cytoskeleton to the plasma membrane and the ECM (4-6). CD44 is constitutively phosphorylated at Ser325 in resting cells. Activation of PKC results in phosphorylation of Ser291, dephosphorylation of Ser325, disassociation of ezrin from CD44, and directional motility (4).

1. Goodison, S. et al. (1999) Mol. Pathol. 52, 189-196. 2. Cichy, J. and Puré, E. (2003) J. Cell Biol. 161, 839-843. 3. Bourguignon, L.Y. et al. (1997) J. Biol. Chem. 272, 27913-27918. 4. Legg, J.W. et al. (2002) Nat. Cell Biol. 4, 399-407. 5. Yonemura, S. et al. (1998) J. Cell Biol. 140, 885-895. 6. Tsukita, S. et al. (1994) J. Cell Biol. 126, 391-401.

Small volumes of anti-CD44 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS125562 is an antibody targeting CD44. Also known as CD44 Polyclonal Antibody. Reactive in Human. Host: Rabbit.