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CD8B1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6283585

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize… More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD8B1, Polyclonal Antibody
Full Product Name
CD8B1, CT (CD8B, CD8B1, T-cell surface glycoprotein CD8 beta chain, CD8b) (MaxLight 650)
Product Gene Name
anti-CD8B1 antibody
Product Synonym Gene Name
CD8B
Product Synonym Names
CD8B; CD8B1; T-cell surface glycoprotein CD8 beta chain; CD8b
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
19.2kDa (172aa)
OMIM
186730
3D Structure
ModBase 3D Structure for P10966
Immunogen
CD8B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 148-176 amino acids from the C-terminal region of human CD8B1.
Conjugate
MaxLight650
Note
Preservative Free

Product Categories/Family for anti-CD8B1 antibody

Antibodies; CD Markers
Applications Tested/Suitable for anti-CD8B1 antibody
Western Blot (WB), FLISA
Application Notes for anti-CD8B1 antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-CD8B1 antibody

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Chen, M.L., et al. Eur. J. Immunol. 39(12):3423-3435(2009). Thakral, D., et al. J. Immunol. 180(11):7431-7442(2008). Stove, V., et al. J. Virol. 79(17):11422-11433(2005). Moody, A.M., et al. J. Biol. Chem. 278(9):7240-7246(2003).

Other Notes

Small volumes of anti-CD8B1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD8B1 purchase

MBS6283585 is an antibody targeting CD8B1. Also known as CD8B1, CT (CD8B, CD8B1, T-cell surface glycoprotein CD8 beta chain, CD8b) (MaxLight 650). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD8B1. It may not necessarily be applicable to this product.

NCBI GI #
4826667
NCBI GeneID
926
NCBI Accession #
NP_004922
UniProt Primary Accession #
P10966
UniProt Secondary Accession #
P14860; P14861; Q15980; Q496E0; Q496E1; Q496E2; Q9UDB4; Q9UDB5; Q9UDB6; Q9UDB7; Q9UDB8
UniProt Related Accession #
P10966
GenBank Nucleotide #
NM_004931.4
NCBI Official Full Name
T-cell surface glycoprotein CD8 beta chain isoform 5
NCBI Official Synonym Full Names
CD8b molecule
NCBI Official Symbol
CD8B
NCBI Official Synonym Symbols
LY3; P37; LEU2; LYT3; CD8B1
UniProt Protein Name
T-cell surface glycoprotein CD8 beta chain
UniProt Synonym Protein Names
CD_antigen: CD8b
UniProt Gene Name
CD8B
UniProt Synonym Gene Names
CD8B1
UniProt Entry Name
CD8B_HUMAN
NCBI Protein Information
T-cell surface glycoprotein CD8 beta chain

UniProt Comments for CD8B1

CD8B: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p12

Cellular Component: T cell receptor complex; integral to plasma membrane; early endosome membrane; plasma membrane; extracellular region; external side of plasma membrane

Molecular Function: protein binding; MHC class I protein binding; coreceptor activity

Biological Process: regulation of immune response; T cell activation; viral reproduction; immune response; regulation of defense response to virus by virus; transmembrane receptor protein tyrosine kinase signaling pathway
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Research Articles on CD8B1

1. results suggest that mycoplasma induces a resistance to multiple drugs in hepatocarcinoma cells which required the interaction of P37 and Annexin A2. The pathway downstream this interaction needs to be explored

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD8B1 antibody

 Reference Product  PubMed Publications
 CD8A antibody  >21 publications with CD8B1 and CD8A
 CD4 antibody  >17 publications with CD8B1 and CD4
 CD3E antibody  >2 publications with CD8B1 and CD3E
 CD247 antibody  >1 publications with CD8B1 and CD247
 CD3G antibody  >1 publications with CD8B1 and CD3G
 ZAP70 antibody  >1 publications with CD8B1 and ZAP70
 CD3D antibody  >1 publications with CD8B1 and CD3D

Pathways associated with anti-CD8B1 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram

Diseases associated with anti-CD8B1 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >2 publications with CD8B1 and Disease Models, Animal
 Death Antibodies  >1 publications with CD8B1 and Death
 Necrosis Antibodies  >1 publications with CD8B1 and Necrosis
 Sepsis Antibodies  >1 publications with CD8B1 and Sepsis
 Liver Diseases Antibodies  >1 publications with CD8B1 and Liver Diseases

Organs/Tissues associated with anti-CD8B1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >29 publications with CD8B1 and Blood
 Thymus Antibodies  >6 publications with CD8B1 and Thymus
 Lymph Node Antibodies  >4 publications with CD8B1 and Lymph Node
 Trachea Antibodies  >2 publications with CD8B1 and Trachea
 Intestine Antibodies  >1 publications with CD8B1 and Intestine
 Lung Antibodies  >1 publications with CD8B1 and Lung
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