CDC45 Antibody – Rabbit Polyclonal

The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

CDC45L: Required for initiation of chromosomal DNA replication. Associated with ORC2. Widely expressed, highest levels are found in adult testis and thymus and in fetal liver. Belongs to the CDC45 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: centrosome; nucleoplasm; nucleus

Molecular Function: 3'-5' DNA helicase activity; chromatin binding; DNA replication origin binding; protein binding; single-stranded DNA binding

Biological Process: DNA replication; DNA replication checkpoint; double-strand break repair via break-induced replication; G1/S transition of mitotic cell cycle; G1/S-specific transcription in mitotic cell cycle; pre-replicative complex assembly; regulation of chromatin silencing at telomere