CDC6 Antibody – Rabbit Polyclonal

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]

CDC6: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. Interacts with PCNA, ORC1L, cyclin-CDK and HUWE1. Belongs to the CDC6/cdc18 family.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 17q21.3

Cellular Component: nucleoplasm; Golgi apparatus; spindle pole; cytoplasm; spindle midzone; nucleus; cytosol

Molecular Function: protein binding; nucleotide binding; chromatin binding; kinase binding; ATP binding

Biological Process: positive regulation of cytokinesis; mitosis; traversing start control point of mitotic cell cycle; regulation of mitotic metaphase/anaphase transition; positive regulation of chromosome segregation; G1/S-specific transcription in mitotic cell cycle; negative regulation of cell proliferation; cell division; negative regulation of DNA replication; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; DNA replication checkpoint; DNA replication; G1/S transition of mitotic cell cycle

Disease: Meier-gorlin Syndrome 5