• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

CDH3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6284173

CDH3 is a classical cadherin from the cadherin superfamily. It is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Aberrant expression of this… More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CDH3, Polyclonal Antibody
Full Product Name
CDH3, CT (CDH3, CDHP, Cadherin-3, Placental cadherin) (Biotin)
Product Gene Name
anti-CDH3 antibody
Product Synonym Names
CDH3; CDHP; Cadherin-3; Placental cadherin
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by Peptide Immunoaffinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
91,418 Da
Chromosome Location
Chromosome: 16; NC_000016.9 (68678151..68732957). Location: 16q22.1
OMIM
114021
3D Structure
ModBase 3D Structure for P22223
Immunogen
CDH3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 666~696 amino acids from the C-terminal region of human CDH3.
Conjugate
Biotin
Note
Preservative Free

Product Categories/Family for anti-CDH3 antibody

Antibodies; Cadherin
Applications Tested/Suitable for anti-CDH3 antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-CDH3 antibody
IHC: 1:10-50
ELISA: 1:1,000
WB: 1:50-100
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CDH3 antibody

Western blot analysis of anti-CDH3 Antibody (C-term) in K562 cell line lysates (35ug/lane). CDH3(arrow) was detected using the purified Pab. Western blot analysis of CDH3 (arrow) using rabbit polyclonal CDH3 Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CDH3 gene (Lane 2) (Origene Technologies).
Rabbit Anti-CDH3 Polyclonal Antibody – Cat# MBS6284173

Immunohistochemistry (IHC) of anti-CDH3 antibody

Formalin-fixed and paraffin-embedded human prostate carcinoma tissue reacted with CDH3 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-CDH3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6284173

Product References and Citations for anti-CDH3 antibody

Indelman, M., Clin. Exp. Dermatol. 32 (2), 191-196 (2007). Paredes, J., Clin. Cancer Res. 11 (16), 5869-5877 (2005).

Other Notes

Small volumes of anti-CDH3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDH3 purchase

MBS6284173 is an antibody targeting CDH3. Also known as CDH3, CT (CDH3, CDHP, Cadherin-3, Placental cadherin) (Biotin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CDH3. It may not necessarily be applicable to this product.

NCBI GI #
14589891
NCBI GeneID
1001
NCBI Accession #
NP_001784.2
UniProt Primary Accession #
P22223
UniProt Secondary Accession #
Q05DI6; B2R6F4
UniProt Related Accession #
P22223
GenBank Nucleotide #
NM_001793.4
NCBI Official Full Name
cadherin-3 preproprotein
NCBI Official Synonym Full Names
cadherin 3, type 1, P-cadherin (placental)
NCBI Official Symbol
CDH3
NCBI Official Synonym Symbols
CDHP; HJMD; PCAD
UniProt Protein Name
Cadherin-3
UniProt Synonym Protein Names
Placental cadherin
UniProt Gene Name
CDH3
UniProt Synonym Gene Names
CDHP; P-cadherin
UniProt Entry Name
CADH3_HUMAN
NCBI Protein Information
cadherin-3; calcium-dependent adhesion protein, placental

NCBI Summary for CDH3

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for CDH3

CDH3: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Interacts with CDCP1. Expressed in some normal epithelial tissues and in some carcinoma cell lines. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: cell-cell adherens junction; cytoplasm; integral to membrane; plasma membrane

Molecular Function: calcium ion binding

Biological Process: response to drug; positive regulation of insulin-like growth factor receptor signaling pathway; intercellular junction assembly and maintenance; wound healing; positive regulation of melanin biosynthetic process; Wnt receptor signaling pathway through beta-catenin; retinal homeostasis; negative regulation of transforming growth factor-beta2 production; hair cycle process; cell-cell adhesion; positive regulation of monophenol monooxygenase activity; negative regulation of catagen; visual perception; keratinization; cell adhesion; homophilic cell adhesion

Disease: Ectodermal Dysplasia, Ectrodactyly, And Macular Dystrophy Syndrome; Hypotrichosis, Congenital, With Juvenile Macular Dystrophy
Show more

Research Articles on CDH3

1. LA carcinomas and carcinomas negative for basal markers were more often negative for epithelial cell adhesion molecule (Ep-CAM) and P-cadherin

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CDH3 antibody

 Reference Product  PubMed Publications
 CTNNB1 antibody  >3 publications with CDH3 and CTNNB1

Pathways associated with anti-CDH3 antibody

 Products by Pathway  Pathway Diagram
 Adherens Junctions Interactions Pathway antibodies  Adherens Junctions Interactions Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Cell-cell Junction Organization Pathway antibodies  Cell-cell Junction Organization Pathway Diagram

Diseases associated with anti-CDH3 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >35 publications with CDH3 and Neoplasms
 Skin Diseases Antibodies  >27 publications with CDH3 and Skin Diseases
 Gastrointestinal Diseases Antibodies  >13 publications with CDH3 and Gastrointestinal Diseases
 Breast Neoplasms Antibodies  >12 publications with CDH3 and Breast Neoplasms
 Colorectal Neoplasms Antibodies  >7 publications with CDH3 and Colorectal Neoplasms
 Neoplasms, Experimental Antibodies  >4 publications with CDH3 and Neoplasms, Experimental
 Adenoma Antibodies  >4 publications with CDH3 and Adenoma
 Ectodermal dysplasia, ectrodactyly, and macular dystrophy Antibodies  >4 publications with CDH3 and Ectodermal dysplasia, ectrodactyly, and macular dystrophy
 Lung Diseases Antibodies  >3 publications with CDH3 and Lung Diseases
 Lung Neoplasms Antibodies  >3 publications with CDH3 and Lung Neoplasms

Organs/Tissues associated with anti-CDH3 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >7 publications with CDH3 and Skin
 Intestine Antibodies  >4 publications with CDH3 and Intestine
 Stomach Antibodies  >4 publications with CDH3 and Stomach
 Liver Antibodies  >4 publications with CDH3 and Liver
 Eye Antibodies  >4 publications with CDH3 and Eye
 Embryonic Tissue Antibodies  >4 publications with CDH3 and Embryonic Tissue
 Lung Antibodies  >3 publications with CDH3 and Lung
 Thyroid Antibodies  >3 publications with CDH3 and Thyroid
 Blood Antibodies  >2 publications with CDH3 and Blood
 Kidney Antibodies  >2 publications with CDH3 and Kidney
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000