• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

CDH8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6466433

MBS6466433 is an antibody targeting CDH8. Also known as CDH8, NT (Cadherin-8, CADH8, Cadherin 8) (MaxLight 550). Reactive in Human. Host: Rabbit. More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CDH8, Polyclonal Antibody
Full Product Name
CDH8, NT (Cadherin-8, CADH8, Cadherin 8) (MaxLight 550)
Product Gene Name
anti-CDH8 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human CDH8.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
81kDa
OMIM
603008
3D Structure
ModBase 3D Structure for P55286
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 33-63 in the N-terminal region of human CDH8, UniProt Accession #NP_001787; P55286.
Conjugate
MaxLight550
Note
Preservative Free

Product Categories/Family for anti-CDH8 antibody

Antibodies; Cadherin
Applications Tested/Suitable for anti-CDH8 antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-CDH8 antibody
IHC: 1:10-1:50
FLISA: 1:1,000
WB: 1:50-1:100
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CDH8 antibody

Western Blot analysis of CDH8 (arrow) usingMBS628652. 293 cell lysates (2ug/lane) either nontransfected (Lane 1) or transiently transfected with the CDH8 gene (Lane 2) (Origene Technologies).
Rabbit Anti-CDH8 Polyclonal Antibody – Cat# MBS6466433

Immunohistochemistry (IHC) of anti-CDH8 antibody

Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted withMBS628652, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Rabbit Anti-CDH8 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6466433

Product References and Citations for anti-CDH8 antibody

1. Blaschke, S., Int. J. Cancer 101(4), 327-334 (2002). 2. Shimoyama, Y., Biochem. J. 349(PT 1), 159-167 (2000).

Other Notes

Small volumes of anti-CDH8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CDH8. It may not necessarily be applicable to this product.

NCBI GI #
16306539
NCBI GeneID
1006
NCBI Accession #
NP_001787
UniProt Primary Accession #
P55286
UniProt Related Accession #
P55286
GenBank Nucleotide #
NM_001796
NCBI Official Full Name
cadherin-8 preproprotein
NCBI Official Synonym Full Names
cadherin 8
NCBI Official Symbol
CDH8
NCBI Official Synonym Symbols
Nbla04261
UniProt Protein Name
Cadherin-8
Protein Family
Cadherin
UniProt Gene Name
CDH8
UniProt Entry Name
CADH8_HUMAN
NCBI Protein Information
cadherin-8

NCBI Summary for CDH8

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for CDH8

CDH8: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: plasma membrane; integral to membrane; nerve terminal

Molecular Function: calcium ion binding

Biological Process: intercellular junction assembly and maintenance; synaptic transmission, glutamatergic; response to cold; cell adhesion; homophilic cell adhesion
Show more

Research Articles on CDH8

1. Results show that promoter hypermethylation of ADCY8, CDH8, and ZNF582 are correlated with high-grade squamous intraepithelial lesion.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CDH8 antibody

 Reference Product  PubMed Publications
 CTNNB1 antibody  >3 publications with CDH8 and CTNNB1

Pathways associated with anti-CDH8 antibody

 Products by Pathway  Pathway Diagram
 Adherens Junctions Interactions Pathway antibodies  Adherens Junctions Interactions Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Cell-cell Junction Organization Pathway antibodies  Cell-cell Junction Organization Pathway Diagram

Diseases associated with anti-CDH8 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >4 publications with CDH8 and Carcinoma
 Respiratory Tract Diseases Antibodies  >2 publications with CDH8 and Respiratory Tract Diseases
 Lung Neoplasms Antibodies  >2 publications with CDH8 and Lung Neoplasms
 Kidney Diseases Antibodies  >2 publications with CDH8 and Kidney Diseases
 Learning Disorders Antibodies  >2 publications with CDH8 and Learning Disorders
 Disease Models, Animal Antibodies  >1 publications with CDH8 and Disease Models, Animal
 Memory Disorders Antibodies  >1 publications with CDH8 and Memory Disorders
 Atrophy Antibodies  >1 publications with CDH8 and Atrophy
 Breast Neoplasms Antibodies  >1 publications with CDH8 and Breast Neoplasms

Organs/Tissues associated with anti-CDH8 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >33 publications with CDH8 and Brain
 Nerve Antibodies  >11 publications with CDH8 and Nerve
 Embryonic Tissue Antibodies  >5 publications with CDH8 and Embryonic Tissue
 Testis Antibodies  >1 publications with CDH8 and Testis
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000