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CDKL2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6284548

CDKL2 is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with a lower level in the nucleus. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CDKL2, Polyclonal Antibody
Full Product Name
CDKL2, ID (CDKL2, Cyclin-dependent kinase-like 2, Protein kinase p56 KKIAMRE, Serine/threonine-protein kinase KKIAMRE) (FITC)
Product Gene Name
anti-CDKL2 antibody
Product Synonym Names
CDKL2; Cyclin-dependent kinase-like 2; Protein kinase p56 KKIAMRE; Serine/threonine-protein kinase KKIAMRE
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
Purity/Purification
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer.
Molecular Weight
56,019 Da
Chromosome Location
Chromosome: 4; NC_000004.11 (76501704..76555721, complement). Location: 4q21.1
OMIM
603442
3D Structure
ModBase 3D Structure for Q92772
Immunogen
CDKL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 233~263 amino acids from the center region of human CDKL2.
Conjugate
FITC
Note
Preservative Free

Product Categories/Family for anti-CDKL2 antibody

Antibodies; Protein Kinases
Applications Tested/Suitable for anti-CDKL2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CDKL2 antibody
WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CDKL2 antibody

Western blot analysis of CDKL2 Center in 293, Jurkat cell line lysates (35ug/lane). CDKL2 (arrow) was detected using the purified Pab.
Rabbit Anti-CDKL2 Polyclonal Antibody – Cat# MBS6284548

Western Blot (WB) of anti-CDKL2 antibody

Western blot analysis of CDKL2 (arrow) using rabbit polyclonal CDKL2 Antibody (Center).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CDKL2 gene (Lane 2) (Origene Technologies).
Rabbit Anti-CDKL2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6284548

Product References and Citations for anti-CDKL2 antibody

Taglienti, C.A., et al., Oncogene 13(12):2563-2574 (1996).

Other Notes

Small volumes of anti-CDKL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDKL2 purchase

MBS6284548 is an antibody targeting CDKL2. Also known as CDKL2, ID (CDKL2, Cyclin-dependent kinase-like 2, Protein kinase p56 KKIAMRE, Serine/threonine-protein kinase KKIAMRE) (FITC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CDKL2. It may not necessarily be applicable to this product.

NCBI GI #
4505569
NCBI GeneID
8999
NCBI Accession #
NP_003939.1
UniProt Primary Accession #
Q92772
UniProt Secondary Accession #
B2R695
UniProt Related Accession #
Q92772
GenBank Nucleotide #
NM_003948.3
NCBI Official Full Name
cyclin-dependent kinase-like 2
NCBI Official Synonym Full Names
cyclin-dependent kinase-like 2 (CDC2-related kinase)
NCBI Official Symbol
CDKL2
NCBI Official Synonym Symbols
P56; KKIAMRE
UniProt Protein Name
Cyclin-dependent kinase-like 2
UniProt Synonym Protein Names
Protein kinase p56 KKIAMRE; Serine/threonine-protein kinase KKIAMRE
Protein Family
Cyclin-dependent kinase
UniProt Gene Name
CDKL2
UniProt Entry Name
CDKL2_HUMAN
NCBI Protein Information
cyclin-dependent kinase-like 2; CDC2-related kinase; p56 KKIAMRE protein kinase; protein kinase p56 KKIAMRE; serine/threonine protein kinase KKIAMRE; serine/threonine-protein kinase KKIAMRE

NCBI Summary for CDKL2

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus. [provided by RefSeq, Jul 2008]

UniProt Comments for CDKL2

CDKL2: a protein kinase of the CDKL family. Accumulates primarily in the cytoplasm, with a lower level in the nucleus.

Protein type: Protein kinase, CMGC; Kinase, protein; Cell cycle regulation; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.22; CMGC group; CDKL family

Chromosomal Location of Human Ortholog: 4q21.1

Cellular Component: nucleoplasm; centrosome; cytoplasm; nucleus

Molecular Function: cyclin-dependent protein kinase activity; ATP binding; protein kinase activity

Biological Process: regulation of cell cycle; signal transduction; protein amino acid phosphorylation; sex differentiation
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Research Articles on CDKL2

1. We hypothesized that LA might induce dissociation of p56(Lck) from CD4, thus leading to its downmodulation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-CDKL2 antibody

 Disease Name  Pubmed Publications
 Drug Toxicity Antibodies  >1 publications with CDKL2 and Drug Toxicity
 Learning Disorders Antibodies  >1 publications with CDKL2 and Learning Disorders
 Breast Neoplasms Antibodies  >1 publications with CDKL2 and Breast Neoplasms
 Kidney Diseases Antibodies  >1 publications with CDKL2 and Kidney Diseases

Organs/Tissues associated with anti-CDKL2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7 publications with CDKL2 and Brain
 Lung Antibodies  >1 publications with CDKL2 and Lung
 Kidney Antibodies  >1 publications with CDKL2 and Kidney
 Testis Antibodies  >1 publications with CDKL2 and Testis
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