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CEACAM3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6284919

This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CEACAM3, Polyclonal Antibody
Full Product Name
CEACAM3, CT (CEACAM3, CD66D, CGM1, Carcinoembryonic antigen-related cell adhesion molecule 3, Carcinoembryonic antigen CGM1, CD66d) (AP)
Product Gene Name
anti-CEACAM3 antibody
Product Synonym Names
CEACAM3; CD66D; CGM1; Carcinoembryonic antigen-related cell adhesion molecule 3; Carcinoembryonic antigen CGM1; CD66d
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
22,754 Da
OMIM
609142
3D Structure
ModBase 3D Structure for P40198
Immunogen
CEACAM3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-191 amino acids from the C-terminal region of human CEACAM3.
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-CEACAM3 antibody

Antibodies; CD Markers
Applications Tested/Suitable for anti-CEACAM3 antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-CEACAM3 antibody
IHC: 1:10-50
ELISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CEACAM3 antibody

Western blot analysis of CEACAM3 (arrow) using rabbit polyclonal CEACAM3 Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CEACAM3 gene.
Rabbit Anti-CEACAM3 Polyclonal Antibody – Cat# MBS6284919

Immunohistochemistry (IHC) of anti-CEACAM3 antibody

CEACAM3 Antibody (C-term) (AP13855b)immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CEACAM3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-CEACAM3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6284919

Product References and Citations for anti-CEACAM3 antibody

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Tsavaris, N., et al. J Chemother 21(6):673-680(2009). Skubitz, K.M., et al. J Transl Med 6, 78 (2008): Stern-Ginossar, N., et al. J. Immunol. 179(7):4424-4434(2007). Ali, C.W., et al. J Gastrointest Cancer 38 (2-4), 108-114 (2007).

Other Notes

Small volumes of anti-CEACAM3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CEACAM3 purchase

MBS6284919 is an antibody targeting CEACAM3. Also known as CEACAM3, CT (CEACAM3, CD66D, CGM1, Carcinoembryonic antigen-related cell adhesion molecule 3, Carcinoembryonic antigen CGM1, CD66d) (AP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CEACAM3. It may not necessarily be applicable to this product.

NCBI GI #
121114300
NCBI GeneID
1084
NCBI Accession #
NP_001806.2
UniProt Primary Accession #
P40198
UniProt Secondary Accession #
Q3KPH9; G5E978
UniProt Related Accession #
P40198
GenBank Nucleotide #
NM_001815.4
NCBI Official Full Name
carcinoembryonic antigen-related cell adhesion molecule 3 isoform 1
NCBI Official Synonym Full Names
carcinoembryonic antigen-related cell adhesion molecule 3
NCBI Official Symbol
CEACAM3
NCBI Official Synonym Symbols
CEA; CGM1; W264; W282; CD66D
UniProt Protein Name
Carcinoembryonic antigen-related cell adhesion molecule 3
UniProt Synonym Protein Names
Carcinoembryonic antigen CGM1; CD_antigen: CD66d
Protein Family
Carcinoembryonic antigen-related cell adhesion molecule
UniProt Gene Name
CEACAM3
UniProt Synonym Gene Names
CD66D; CGM1
UniProt Entry Name
CEAM3_HUMAN
NCBI Protein Information
carcinoembryonic antigen-related cell adhesion molecule 3; CD66d antigen; carcinoembryonic antigen CGM1; nonspecific cross-reacting antigen; carcinoembryonic antigen gene family member 1

UniProt Comments for CEACAM3

CEACAM3: Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis. Interacts with S100A9/calprotectin. This interaction is calcium-dependent, but independent of CEACAM3 phosphorylation. CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney. Belongs to the immunoglobulin superfamily. CEA family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: integral to membrane
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CEACAM3 antibody

 Reference Product  PubMed Publications
 CEACAM1 antibody  >31 publications with CEACAM3 and CEACAM1
 SRC antibody  >11 publications with CEACAM3 and SRC
 VAV1 antibody  >1 publications with CEACAM3 and VAV1

Diseases associated with anti-CEACAM3 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >4 publications with CEACAM3 and Necrosis
 Inflammation Antibodies  >3 publications with CEACAM3 and Inflammation
 Lung Diseases Antibodies  >3 publications with CEACAM3 and Lung Diseases
 Adenocarcinoma Antibodies  >2 publications with CEACAM3 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >2 publications with CEACAM3 and Neoplasms, Experimental
 Pneumonia Antibodies  >1 publications with CEACAM3 and Pneumonia

Organs/Tissues associated with anti-CEACAM3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >26 publications with CEACAM3 and Blood
 Spleen Antibodies  >2 publications with CEACAM3 and Spleen
 Placenta Antibodies  >1 publications with CEACAM3 and Placenta
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