Rabbit Anti-CENPO Polyclonal Antibody – Cat# MBS6285142

CENPO Antibody (N-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the CENPO antibody detected the CENPO protein (arrow).

CENPO Antibody – Rabbit Polyclonal

Name: CENPO Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6285142
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6285142

CENPO is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]). More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CENPO, Polyclonal Antibody

Full Product Name

CENPO, NT (CENPO, ICEN36, MCM21R, Centromere protein O, Interphase centromere complex protein 36) (FITC)

Product Gene Name

anti-CENPO antibody

Product Synonym Names

CENPO; ICEN36; MCM21R; Centromere protein O; Interphase centromere complex protein 36

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

OMIM

611504

3D Structure

ModBase 3D Structure for Q9BU64

Immunogen

CENPO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-69 amino acids from the N-terminal region of human CENPO.

Conjugate

FITC

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-CENPO antibody

Antibodies; Centromeres

Applications Tested/Suitable for anti-CENPO antibody

Western Blot (WB), FLISA

Application Notes for anti-CENPO antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-CENPO antibody

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Xin, X., et al. Genome Res. 19(7):1262-1269(2009). Saito, A., et al. J. Rheumatol. 36(4):781-786(2009). Lamesch, P., et al. Genomics 89(3):307-315(2007). Izuta, H., et al. Genes Cells 11(6):673-684(2006).

Other Notes

Small volumes of anti-CENPO antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CENPO purchase

MBS6285142 is an antibody targeting CENPO. Also known as CENPO, NT (CENPO, ICEN36, MCM21R, Centromere protein O, Interphase centromere complex protein 36) (FITC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CENPO. It may not necessarily be applicable to this product.

NCBI GI #

13236565

NCBI GeneID

79172

NCBI Accession #

NP_077298.1

UniProt Primary Accession #

Q9BU64

UniProt Related Accession #

Q9BU64

GenBank Nucleotide #

NP_077298.1

NCBI Official Full Name

centromere protein O isoform 1

NCBI Official Synonym Full Names

centromere protein O

NCBI Official Symbol

CENPO

NCBI Official Synonym Symbols

CENP-O; MCM21R; ICEN-36

UniProt Protein Name

Centromere protein O

UniProt Synonym Protein Names

Interphase centromere complex protein 36

Protein Family

Centromere protein

UniProt Gene Name

CENPO

UniProt Synonym Gene Names

ICEN36; MCM21R; CENP-O

UniProt Entry Name

CENPO_HUMAN

NCBI Protein Information

centromere protein O

NCBI Summary for CENPO

This gene encodes a component of the interphase centromere complex. The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during mitosis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

UniProt Comments for CENPO

CENPO: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: nucleoplasm; cytosol

Biological Process: nucleosome assembly; DNA replication-independent nucleosome assembly at centromere; mitotic cell cycle

Research Articles on CENPO

1. Knockdown of CENPO contributed to Gastric Cancer cell growth inhibition and apoptosis induction.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CENPO antibody

Reference Product	PubMed Publications
CENPQ antibody	>1 publications with CENPO and CENPQ
MLF1IP antibody	>1 publications with CENPO and MLF1IP

Pathways associated with anti-CENPO antibody

Products by Pathway	Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle, Mitotic Pathway antibodies	Cell Cycle, Mitotic Pathway Diagram
Chromosome Maintenance Pathway antibodies	Chromosome Maintenance Pathway Diagram
Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway antibodies	Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway Diagram
M Phase Pathway antibodies	M Phase Pathway Diagram
Mitotic Anaphase Pathway antibodies	Mitotic Anaphase Pathway Diagram
Mitotic Metaphase And Anaphase Pathway antibodies	Mitotic Metaphase And Anaphase Pathway Diagram
Mitotic Prometaphase Pathway antibodies	Mitotic Prometaphase Pathway Diagram
Nucleosome Assembly Pathway antibodies	Nucleosome Assembly Pathway Diagram
Resolution Of Sister Chromatid Cohesion Pathway antibodies	Resolution Of Sister Chromatid Cohesion Pathway Diagram

Diseases associated with anti-CENPO antibody

Disease Name	Pubmed Publications
Neoplasms, Experimental Antibodies	>3 publications with CENPO and Neoplasms, Experimental
Disease Models, Animal Antibodies	>2 publications with CENPO and Disease Models, Animal
Lung Neoplasms Antibodies	>1 publications with CENPO and Lung Neoplasms
Diabetes Mellitus Antibodies	>1 publications with CENPO and Diabetes Mellitus
Liver Neoplasms Antibodies	>1 publications with CENPO and Liver Neoplasms
Liver Neoplasms, Experimental Antibodies	>1 publications with CENPO and Liver Neoplasms, Experimental

Organs/Tissues associated with anti-CENPO antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>2 publications with CENPO and Blood
Bone Antibodies	>1 publications with CENPO and Bone
Spleen Antibodies	>1 publications with CENPO and Spleen
Heart Antibodies	>1 publications with CENPO and Heart
Liver Antibodies	>1 publications with CENPO and Liver
Lung Antibodies	>1 publications with CENPO and Lung