Rabbit Anti-CES2 Polyclonal Antibody – Cat# MBS6373745

Western Blot analysis of CES2 expression in transfected 293T cell line by CES2 polyclonal antibody. Lane 1: CES2 transfected lysate (68.9kD). Lane 2: Non-transfected lysate.

CES2 Antibody – Rabbit Polyclonal

Name: CES2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6373745
Price: 1165 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6373745

CES2 is a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CES2, Polyclonal Antibody

Full Product Name

CES2 (Cocaine Esterase, Carboxylesterase 2, CE-2, hCE-2, Methylumbelliferyl-acetate Deacetylase 2, ICE, CES2A1) (HRP)

Product Gene Name

anti-CES2 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Specificity

Recognizes human CES2.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

61,807 Da

Chromosome Location

Chromosome: 16; NC_000016.9 (66968347..66978999). Location: 16q22.1

OMIM

605278

3D Structure

ModBase 3D Structure for O00748

Immunogen

Full length human CES2, aa1-623 (NP_003860.2).

Immunogen Sequence

MTAQSRSPTTPTFPGPSQRTPLTPCPVQTPRLGKALIHCWTDPGQPLGEQQRVRRQRTETSEPTMRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEILAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPALQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIKFTEEEEQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEERHTEL

Conjugate

HRP

Note

Preservative Free

Product Categories/Family for anti-CES2 antibody

Antibodies; Enzymes; Phosphodiesterase

Applications Tested/Suitable for anti-CES2 antibody

Western Blot (WB)

Application Notes for anti-CES2 antibody

Applications are based on unconjugated antibody.

Other Notes

Small volumes of anti-CES2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CES2 purchase

MBS6373745 is an antibody targeting CES2. Also known as CES2 (Cocaine Esterase, Carboxylesterase 2, CE-2, hCE-2, Methylumbelliferyl-acetate Deacetylase 2, ICE, CES2A1) (HRP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CES2. It may not necessarily be applicable to this product.

NCBI GI #

37622885

NCBI GeneID

8824

NCBI Accession #

NP_003860.2

UniProt Primary Accession #

O00748

UniProt Secondary Accession #

Q16859; Q5MAB8; Q7Z366; Q8IUP4; Q8TCP8

UniProt Related Accession #

O00748

GenBank Nucleotide #

NM_003869.4

NCBI Official Full Name

cocaine esterase isoform 1

NCBI Official Synonym Full Names

carboxylesterase 2

NCBI Official Symbol

CES2

NCBI Official Synonym Symbols

iCE; CE-2; PCE-2; CES2A1

UniProt Protein Name

Cocaine esterase

UniProt Synonym Protein Names

Carboxylesterase 2 (EC:3.1.1.1); CE-2; hCE-2; Methylumbelliferyl-acetate deacetylase 2 (EC:3.1.1.56)

Protein Family

Liver carboxylesterase

UniProt Gene Name

CES2

UniProt Synonym Gene Names

ICE; CE-2; hCE-2

UniProt Entry Name

EST2_HUMAN

NCBI Protein Information

cocaine esterase; hCE-2; carboxylesterase 2 (intestine, liver); methylumbelliferyl-acetate deacetylase 2; intestinal carboxylesterase; liver carboxylesterase-2

NCBI Summary for CES2

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]

UniProt Comments for CES2

CES2: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.1.56; EC 3.1.1.84; Xenobiotic Metabolism - drug metabolism - other enzymes; Endoplasmic reticulum; EC 3.1.1.1; Hydrolase

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: extracellular space; endoplasmic reticulum; endoplasmic reticulum lumen

Molecular Function: methylumbelliferyl-acetate deacetylase activity

Biological Process: catabolic process

Research Articles on CES2

1. tested the hypothesis that an individual's CES phenotype can be characterized by reporter substrates/probes that interrogate native CES1 and CES2 activities in liver and immunoblotting methods

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CES2 antibody

Products by Pathway	Pathway Diagram
Drug Metabolism - Other Enzymes Pathway antibodies	Drug Metabolism - Other Enzymes Pathway Diagram
Drug Metabolism - Other Enzymes Pathway antibodies	Drug Metabolism - Other Enzymes Pathway Diagram
E2F Transcription Factor Network Pathway antibodies	E2F Transcription Factor Network Pathway Diagram
Fluoropyrimidine Activity Pathway antibodies	Fluoropyrimidine Activity Pathway Diagram
Irinotecan Pathway antibodies	Irinotecan Pathway Diagram
Phase I, Non P450 Pathway antibodies	Phase I, Non P450 Pathway Diagram
Retinol Biosynthesis Pathway antibodies	Retinol Biosynthesis Pathway Diagram

Diseases associated with anti-CES2 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>25 publications with CES2 and Neoplasms
Drug Toxicity Antibodies	>18 publications with CES2 and Drug Toxicity
Liver Neoplasms Antibodies	>10 publications with CES2 and Liver Neoplasms
Liver Diseases Antibodies	>8 publications with CES2 and Liver Diseases
Inflammation Antibodies	>4 publications with CES2 and Inflammation
Fatty Liver Antibodies	>4 publications with CES2 and Fatty Liver
Lung Neoplasms Antibodies	>3 publications with CES2 and Lung Neoplasms
Carcinoma, Hepatocellular Antibodies	>3 publications with CES2 and Carcinoma, Hepatocellular
Hypertrophy Antibodies	>3 publications with CES2 and Hypertrophy
Cardiovascular Diseases Antibodies	>2 publications with CES2 and Cardiovascular Diseases

Organs/Tissues associated with anti-CES2 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>65 publications with CES2 and Liver
Intestine Antibodies	>29 publications with CES2 and Intestine
Blood Antibodies	>19 publications with CES2 and Blood
Kidney Antibodies	>10 publications with CES2 and Kidney
Lung Antibodies	>9 publications with CES2 and Lung
Brain Antibodies	>6 publications with CES2 and Brain
Bone Antibodies	>4 publications with CES2 and Bone
Heart Antibodies	>3 publications with CES2 and Heart
Prostate Antibodies	>3 publications with CES2 and Prostate
Muscle Antibodies	>3 publications with CES2 and Muscle