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CHML Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9413637

Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its… More details

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Product Overview

Online Datasheet in PDF
Product Name
CHML, Polyclonal Antibody
Full Product Name
CHML Antibody
Product Gene Name
Product Synonym Names
Rab proteins geranylgeranyltransferase component A 2; Rab escort protein 2; REP-2; Choroideraemia-like protein
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1.0 mg/ml (lot specific)
Specificity
The antibody detects endogenous levels of total CHML protein.
Preparation and Storage
Store at -20 degree C
Molecular Weight
74,071 Da
OMIM
118825
3D Structure
ModBase 3D Structure for P26374
Immunogen Type
Peptide
Immunogen Description
Synthesized peptide derived from internal of human CHML.
Target Name
CHML

Product Categories/Family for anti-CHML antibody

Applications Tested/Suitable for anti-CHML antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CHML antibody
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Western Blot (WB) of anti-CHML antibody

Western blot analysis of extracts from COLO cells, using CHML antibody.
Rabbit Anti-CHML Polyclonal Antibody – Cat# MBS9413637

Immunohistochemistry (IHC) of anti-CHML antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using CHML antibody.
Rabbit Anti-CHML Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9413637

Other Notes

Small volumes of anti-CHML antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CHML purchase

MBS9413637 is an antibody targeting CHML. Also known as CHML Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CHML. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
rab proteins geranylgeranyltransferase component A 2
NCBI Official Synonym Full Names
choroideremia-like (Rab escort protein 2)
NCBI Official Symbol
CHML
NCBI Official Synonym Symbols
REP2
UniProt Protein Name
Rab proteins geranylgeranyltransferase component A 2
UniProt Synonym Protein Names
Choroideremia-like protein; Rab escort protein 2; REP-2
UniProt Gene Name
CHML
UniProt Synonym Gene Names
REP2; REP-2
UniProt Entry Name
RAE2_HUMAN
NCBI Protein Information
rab proteins geranylgeranyltransferase component A 2

NCBI Summary for CHML

The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II. [provided by RefSeq, Jul 2008]

UniProt Comments for CHML

CHML: Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than REP-1 in supporting prenylation of Rab3 family. Belongs to the Rab GDI family.

Chromosomal Location of Human Ortholog: 1q43

Cellular Component: nucleoplasm; Rab-protein geranylgeranyltransferase complex; cytoplasm; cytosol

Molecular Function: GTPase activator activity; Rab GTPase binding; Rab-protein geranylgeranyltransferase activity

Biological Process: protein geranylgeranylation; intracellular protein transport; positive regulation of GTPase activity
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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