Rabbit Anti-CIDEA Polyclonal Antibody – Cat# MBS6286165

CIDEA Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the CIDEA antibody detected the CIDEA protein (arrow).

CIDEA Antibody – Rabbit Polyclonal

Name: CIDEA Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6286165
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6286165

This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CIDEA, Polyclonal Antibody

Full Product Name

CIDEA, CT (CIDEA, Cell death activator CIDE-A, Cell death-inducing DFFA-like effector A) (FITC)

Product Gene Name

anti-CIDEA antibody

Product Synonym Names

CIDEA; Cell death activator CIDE-A; Cell death-inducing DFFA-like effector A

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

24,687 Da

Chromosome Location

Chromosome: 18; NC_000018.9 (12254318..12277594). Location: 18p11.21; 18

OMIM

604440

3D Structure

ModBase 3D Structure for O60543

Immunogen

CIDEA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-209 amino acids from the C-terminal region of human CIDEA.

Conjugate

FITC

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-CIDEA antibody

Antibodies; Apoptosis

Applications Tested/Suitable for anti-CIDEA antibody

Western Blot (WB), FLISA

Application Notes for anti-CIDEA antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-CIDEA antibody

Li, F., et al. FEBS J. 277(20):4173-4183(2010). Ito, M., et al. J. Lipid Res. 51(7):1676-1684(2010). Huang, Y.W., et al. Gynecol. Oncol. 117(2):239-247(2010). Laurencikiene, J., et al. Cancer Res. 68(22):9247-9254(2008). Valouskova, E., et al. Gen. Physiol. Biophys. 27(2):92-100(2008).

Other Notes

Small volumes of anti-CIDEA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CIDEA purchase

MBS6286165 is an antibody targeting CIDEA. Also known as CIDEA, CT (CIDEA, Cell death activator CIDE-A, Cell death-inducing DFFA-like effector A) (FITC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CIDEA. It may not necessarily be applicable to this product.

NCBI GI #

4557465

NCBI GeneID

1149

NCBI Accession #

NP_001270.1

UniProt Primary Accession #

O60543

UniProt Secondary Accession #

Q6UPR7; B0YIY7

UniProt Related Accession #

O60543; Q8N5P9

GenBank Nucleotide #

NM_001279.3

NCBI Official Full Name

cell death activator CIDE-A isoform 1

NCBI Official Synonym Full Names

cell death-inducing DFFA-like effector a

NCBI Official Symbol

CIDEA

NCBI Official Synonym Symbols

CIDE-A

UniProt Protein Name

Cell death activator CIDE-A

UniProt Synonym Protein Names

Cell death-inducing DFFA-like effector A

Protein Family

Cell death activator

UniProt Gene Name

CIDEA

UniProt Entry Name

CIDEA_HUMAN

NCBI Protein Information

cell death activator CIDE-A; OTTHUMP00000162472

UniProt Comments for CIDEA

CIDEA: Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter. Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear. In omental and subcutaneous adipose tissue of obese patients matched for BMI, expression levels correlate with insulin sensitivity. Expression is increased 5-6 fold in the group of patients with high insulin sensitivity, compared to the insulin- resistant group. This observation is consistent with the idea that triglyceride storage in adipocytes plays an important role in sequestering triglycerides and fatty acids away from the circulation and peripheral tissues, thus enhancing insulin sensitivity in liver and muscle.

Protein type: Apoptosis; Mitochondrial

Chromosomal Location of Human Ortholog: 18p11.21|18

Cellular Component: mitochondrial envelope; mitochondrion; cytoplasm; lipid particle; nucleus

Molecular Function: protein homodimerization activity

Biological Process: cell death; regulation of apoptosis; sequestering of lipid; regulation of transcription, DNA-dependent; transcription, DNA-dependent; negative regulation of lipid catabolic process; apoptosis; negative regulation of cytokine secretion; lipid metabolic process; negative regulation of tumor necrosis factor production; thermoregulation; negative regulation of transforming growth factor beta receptor signaling pathway

Research Articles on CIDEA

1. The proportion of subjects with CIDEA) gene V115F (G/T) polymorphism with phenotypes of metabolic syndrome in a Chinese population was significantly higher based on genotype, in the order: GG

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CIDEA antibody

Reference Product	PubMed Publications
CIDEB antibody	>13 publications with CIDEA and CIDEB
UCP1 antibody	>9 publications with CIDEA and UCP1

Diseases associated with anti-CIDEA antibody

Disease Name	Pubmed Publications
Death Antibodies	>40 publications with CIDEA and Death
Obesity Antibodies	>32 publications with CIDEA and Obesity
Metabolic Diseases Antibodies	>13 publications with CIDEA and Metabolic Diseases
Insulin Resistance Antibodies	>12 publications with CIDEA and Insulin Resistance
Fatty Liver Antibodies	>10 publications with CIDEA and Fatty Liver
Liver Diseases Antibodies	>9 publications with CIDEA and Liver Diseases
Inflammation Antibodies	>6 publications with CIDEA and Inflammation
Necrosis Antibodies	>6 publications with CIDEA and Necrosis
Neoplasms Antibodies	>6 publications with CIDEA and Neoplasms
Cardiovascular Diseases Antibodies	>3 publications with CIDEA and Cardiovascular Diseases

Organs/Tissues associated with anti-CIDEA antibody

Organ/Tissue Name	Pubmed Publications
Adipose Tissue Antibodies	>37 publications with CIDEA and Adipose Tissue
Brain Antibodies	>2 publications with CIDEA and Brain
Heart Antibodies	>2 publications with CIDEA and Heart