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CLASP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6469175

MBS6469175 is an antibody targeting CLASP2. Also known as CLASP2, NT (CLIP-associating Protein 2, Cytoplasmic Linker-associated Protein 2, Protein Orbit Homolog 2, hOrbit2, KIAA0627) (AP). Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CLASP2, Polyclonal Antibody
Full Product Name
CLASP2, NT (CLIP-associating Protein 2, Cytoplasmic Linker-associated Protein 2, Protein Orbit Homolog 2, hOrbit2, KIAA0627) (AP)
Product Gene Name
anti-CLASP2 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified by Protein G Affinity Chromatography.
Specificity
Recognizes human CLASP2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Do not freeze alkaline phosphatase conjugates which could result in a substantial loss of enzymatic activity. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
165,924 Da
OMIM
605853
3D Structure
ModBase 3D Structure for O75122
Immunogen
Synthetic peptide selected from the N-terminal region of human CLASP2 (KLH).
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-CLASP2 antibody

Antibodies; Proteins
Applications Tested/Suitable for anti-CLASP2 antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-CLASP2 antibody
IHC: 1:10-1:50
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-CLASP2 antibody

1. Pereira, A.L., Mol. Biol. Cell 17(10), 4526-4542 (2006). 2. Mimori-Kiyosue, Y., Genes Cells 11(8), 845-857 (2006). 3. Lansbergen, G., Dev. Cell 11(1), 21-32 (2006).

Other Notes

Small volumes of anti-CLASP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CLASP2. It may not necessarily be applicable to this product.

NCBI GI #
333440449
NCBI GeneID
23122
NCBI Accession #
NP_055912
UniProt Primary Accession #
O75122
UniProt Secondary Accession #
Q7L8F6; Q8N6R6; Q9BQT3; Q9BQT4; Q9H7A3; Q9NSZ2; B2RTR1; F5H604
UniProt Related Accession #
O75122
GenBank Nucleotide #
NM_015097.2
NCBI Official Full Name
CLIP-associating protein 2 isoform 1
NCBI Official Synonym Full Names
cytoplasmic linker associated protein 2
NCBI Official Symbol
CLASP2
UniProt Protein Name
CLIP-associating protein 2
UniProt Synonym Protein Names
Cytoplasmic linker-associated protein 2; Protein Orbit homolog 2; hOrbit2
Protein Family
CLIP-associating protein
UniProt Gene Name
CLASP2
UniProt Synonym Gene Names
KIAA0627; hOrbit2
UniProt Entry Name
CLAP2_HUMAN
NCBI Protein Information
CLIP-associating protein 2

UniProt Comments for CLASP2

CLASP2: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. Belongs to the CLASP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 3p22.3

Cellular Component: kinetochore microtubule; Golgi apparatus; microtubule; membrane; cytoplasmic microtubule; cytoplasm; plasma membrane; microtubule organizing center; cell cortex; trans-Golgi network; cytosol

Molecular Function: microtubule plus-end binding; protein binding; galactoside 2-alpha-L-fucosyltransferase activity

Biological Process: mitosis; microtubule organizing center organization and biogenesis; axon guidance; regulation of microtubule-based process; cell division; negative regulation of microtubule depolymerization; establishment and/or maintenance of cell polarity; mitotic cell cycle; microtubule nucleation; regulation of microtubule polymerization or depolymerization
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Research Articles on CLASP2

1. PAR3 and aPKC control the organization of the Golgi through CLASP2 phosphorylation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CLASP2 antibody

 Reference Product  PubMed Publications
 FEZ1 antibody  >2 publications with CLASP2 and FEZ1

Pathways associated with anti-CLASP2 antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Anaphase Pathway antibodies  Mitotic Anaphase Pathway Diagram
 Mitotic Metaphase And Anaphase Pathway antibodies  Mitotic Metaphase And Anaphase Pathway Diagram
 Mitotic Prometaphase Pathway antibodies  Mitotic Prometaphase Pathway Diagram
 RHO GTPase Effectors Pathway antibodies  RHO GTPase Effectors Pathway Diagram
 RHO GTPases Activate Formins Pathway antibodies  RHO GTPases Activate Formins Pathway Diagram

Diseases associated with anti-CLASP2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with CLASP2 and Neoplasms
 Lung Neoplasms Antibodies  >1 publications with CLASP2 and Lung Neoplasms
 Breast Neoplasms Antibodies  >1 publications with CLASP2 and Breast Neoplasms

Organs/Tissues associated with anti-CLASP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >5 publications with CLASP2 and Nerve
 Brain Antibodies  >3 publications with CLASP2 and Brain
 Eye Antibodies  >2 publications with CLASP2 and Eye
 Spinal Cord Antibodies  >1 publications with CLASP2 and Spinal Cord
 Lung Antibodies  >1 publications with CLASP2 and Lung
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