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CMPK2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6287061

Mitochondrial UMP-CMP kinase (EC 2.7.2.14) is a component of the salvage pathway for nucleotide synthesis. Other enzymes of the salvage pathway include thymidine kinase-2 (TK2; MIM 188250), deoxynucleotidase-2 (NT5M; MIM 605292), deoxyguanosine kinase (DGUOK;… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CMPK2, Polyclonal Antibody
Full Product Name
CMPK2, ID (CMPK2, UMP-CMP kinase 2, mitochondrial) (MaxLight 650)
Product Gene Name
anti-CMPK2 antibody
Product Synonym Names
CMPK2; UMP-CMP kinase 2, mitochondrial
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
49 kDa
OMIM
611787
3D Structure
ModBase 3D Structure for Q5EBM0
Immunogen
CMPK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 150-180 amino acids from the Central region of human CMPK2.
Conjugate
MaxLight650
Note
Preservative Free

Product Categories/Family for anti-CMPK2 antibody

Antibodies; Protein Kinases
Applications Tested/Suitable for anti-CMPK2 antibody
Flow Cytometry (FC/FACS), FLISA, Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-CMPK2 antibody
FC/FACS: 1:10-50
FLISA: 1:1,000
IHC: 1:50-100
WB: 1:100-500
Applications are based on unconjugated antibody.

Product References and Citations for anti-CMPK2 antibody

Xu, Y., et al. J. Biol. Chem. 283(3):1563-1571(2008).

Other Notes

Small volumes of anti-CMPK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CMPK2 purchase

MBS6287061 is an antibody targeting CMPK2. Also known as CMPK2, ID (CMPK2, UMP-CMP kinase 2, mitochondrial) (MaxLight 650). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CMPK2. It may not necessarily be applicable to this product.

NCBI GI #
117606370
NCBI GeneID
129607
NCBI Accession #
NP_997198
UniProt Primary Accession #
Q5EBM0
UniProt Secondary Accession #
Q6ZRU2; Q96AL8; A2RUB0; A5D8T2; B7ZM18
UniProt Related Accession #
Q5EBM0
GenBank Nucleotide #
NM_207315.3
NCBI Official Full Name
UMP-CMP kinase 2, mitochondrial isoform 1
NCBI Official Synonym Full Names
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
NCBI Official Symbol
CMPK2
NCBI Official Synonym Symbols
TYKi; TMPK2; UMP-CMPK2
UniProt Protein Name
UMP-CMP kinase 2, mitochondrial
UniProt Synonym Protein Names
Nucleoside-diphosphate kinase (EC:2.7.4.6)
UniProt Gene Name
CMPK2
UniProt Entry Name
CMPK2_HUMAN
NCBI Protein Information
UMP-CMP kinase 2, mitochondrial; cytidylate kinase 2; mitochondrial UMP-CMP kinase; nucleoside-diphosphate kinase; thymidine monophosphate kinase 2; thymidylate kinase family LPS-inducible member

NCBI Summary for CMPK2

This gene encodes one of the enzymes in the nucleotide synthesis salvage pathway that may participate in terminal differentiation of monocytic cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

UniProt Comments for CMPK2

CMPK2: May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Belongs to the thymidylate kinase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.4.6; Nucleotide Metabolism - pyrimidine; EC 2.7.4.14; Kinase, other

Chromosomal Location of Human Ortholog: 2p25.2

Cellular Component: nucleoplasm; mitochondrion; cytosol

Molecular Function: UMP kinase activity; nucleoside diphosphate kinase activity; thymidylate kinase activity; cytidylate kinase activity; ATP binding

Biological Process: dUDP biosynthetic process; nucleoside triphosphate biosynthetic process; dTDP biosynthetic process; dTTP biosynthetic process; nucleoside diphosphate phosphorylation
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Research Articles on CMPK2

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CMPK2 antibody

 Reference Product  PubMed Publications
 RSAD2 antibody  >2 publications with CMPK2 and RSAD2

Pathways associated with anti-CMPK2 antibody

 Products by Pathway  Pathway Diagram
 CMP Phosphorylation Pathway antibodies  CMP Phosphorylation Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Ribonucleotide Biosynthesis, UMP => UDP/UTP,CDP/CTP Pathway antibodies  Pyrimidine Ribonucleotide Biosynthesis, UMP => UDP/UTP,CDP/CTP Pathway Diagram
 Pyrimidine Ribonucleotide Biosynthesis, UMP => UDP/UTP,CDP/CTP Pathway antibodies  Pyrimidine Ribonucleotide Biosynthesis, UMP => UDP/UTP,CDP/CTP Pathway Diagram
 UTP And CTP De Novo Biosynthesis Pathway antibodies  UTP And CTP De Novo Biosynthesis Pathway Diagram
 Pyrimidine Deoxyribonucleotide Phosphorylation Pathway antibodies  Pyrimidine Deoxyribonucleotide Phosphorylation Pathway Diagram
 Superpathway Of Pyrimidine Deoxyribonucleoside Salvage antibodies  Superpathway Of Pyrimidine Deoxyribonucleoside Salvage Diagram
 Superpathway Of Pyrimidine Deoxyribonucleotides De Novo Biosynthesis antibodies  Superpathway Of Pyrimidine Deoxyribonucleotides De Novo Biosynthesis Diagram

Diseases associated with anti-CMPK2 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1 publications with CMPK2 and Nervous System Diseases
 Liver Diseases Antibodies  >1 publications with CMPK2 and Liver Diseases

Organs/Tissues associated with anti-CMPK2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with CMPK2 and Blood
 Liver Antibodies  >1 publications with CMPK2 and Liver
 Bone Marrow Antibodies  >1 publications with CMPK2 and Bone Marrow
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