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CNO6L Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6287268

MBS6287268 is an antibody targeting CNO6L. Also known as CNO6L, CT (CNOT6L, CCR4B, CCR4-NOT transcription complex subunit 6-like, Carbon catabolite repressor protein 4 homolog B) (MaxLight 490). Reactive in Human. Host: Rabbit. More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CNO6L, Polyclonal Antibody
Full Product Name
CNO6L, CT (CNOT6L, CCR4B, CCR4-NOT transcription complex subunit 6-like, Carbon catabolite repressor protein 4 homolog B) (MaxLight 490)
Product Gene Name
anti-CNO6L antibody
Product Synonym Gene Name
CNOT6L
Product Synonym Names
CNOT6L; CCR4B; CCR4-NOT transcription complex subunit 6-like; Carbon catabolite repressor protein 4 homolog B
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human CNO6L.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
63,001 Da
3D Structure
ModBase 3D Structure for Q96LI5
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 414-442 in the C-terminal region of human CNO6L, UniProt Accession #Q96LI5. Species sequence homology: mouse, xenopus
Conjugate
MaxLight490
Note
Preservative Free

Product Categories/Family for anti-CNO6L antibody

Antibodies; Transcription Factors
Applications Tested/Suitable for anti-CNO6L antibody
Immunohistochemistry (IHC), Western Blot (WB), FLISA
Application Notes for anti-CNO6L antibody
IHC: 1:50-1:100
WB: 1:1000
Applications are based on unconjugated antibody.

Product References and Citations for anti-CNO6L antibody

Miyasaka, T., et al. Cancer Sci. 99(4):755-761(2008). Morita, M., et al. Mol. Cell. Biol. 27(13):4980-4990(2007). Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007).

Other Notes

Small volumes of anti-CNO6L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CNO6L. It may not necessarily be applicable to this product.

NCBI GI #
166216089
NCBI GeneID
246175
NCBI Accession #
Q96LI5.2
UniProt Primary Accession #
Q96LI5
UniProt Secondary Accession #
Q9UF92
UniProt Related Accession #
Q96LI5
NCBI Official Full Name
CCR4-NOT transcription complex subunit 6-like
NCBI Official Synonym Full Names
CCR4-NOT transcription complex, subunit 6-like
NCBI Official Symbol
CNOT6L
NCBI Official Synonym Symbols
CCR4b
UniProt Protein Name
CCR4-NOT transcription complex subunit 6-like
UniProt Synonym Protein Names
Carbon catabolite repressor protein 4 homolog B
UniProt Gene Name
CNOT6L
UniProt Synonym Gene Names
CCR4B
UniProt Entry Name
CNO6L_HUMAN
NCBI Protein Information
CCR4-NOT transcription complex subunit 6-like; carbon catabolite repressor protein 4 homolog B

UniProt Comments for CNO6L

CNOT6L: Plays a role in the deadenylation of mRNAs in the cytoplasm. Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation- dependent degradation of CDKN1B mRNA. Belongs to the CCR4/nocturin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; EC 3.1.13.4

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: cytoplasm; cytosol; nucleus; CCR4-NOT complex

Molecular Function: protein binding; poly(A)-specific ribonuclease activity; metal ion binding

Biological Process: regulation of translation; poly(A) tail shortening; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; RNA-mediated gene silencing; gene expression; mRNA catabolic process, deadenylation-dependent decay
Show more

Research Articles on CNO6L

1. Cnot6L, a validated target of miR-146a, affects the stability of Zeb1 mRNA.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CNO6L antibody

 Products by Pathway  Pathway Diagram
 Deadenylation Of MRNA Pathway antibodies  Deadenylation Of MRNA Pathway Diagram
 Deadenylation-dependent MRNA Decay Pathway antibodies  Deadenylation-dependent MRNA Decay Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram

Diseases associated with anti-CNO6L antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1 publications with CNO6L and Neoplasms

Organs/Tissues associated with anti-CNO6L antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1 publications with CNO6L and Blood
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