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CNOT2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6287276

This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CNOT2, Polyclonal Antibody
Full Product Name
CNOT2, ID (CNOT2, CDC36, NOT2, CCR4-NOT transcription complex subunit 2, CCR4-associated factor 2) (FITC)
Product Gene Name
anti-CNOT2 antibody
Product Synonym Names
CNOT2; CDC36; NOT2; CCR4-NOT transcription complex subunit 2; CCR4-associated factor 2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
54,306 Da
OMIM
604909
3D Structure
ModBase 3D Structure for Q9NZN8
Immunogen
CNOT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 271-301 amino acids from the Central region of human CNOT2.
Conjugate
FITC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-CNOT2 antibody

Antibodies; Transcription Factors
Applications Tested/Suitable for anti-CNOT2 antibody
Western Blot (WB), FLISA
Application Notes for anti-CNOT2 antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CNOT2 antibody

CNOT2 Antibody (Center) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CNOT2 antibody detected the CNOT2 protein (arrow).
Rabbit Anti-CNOT2 Polyclonal Antibody – Cat# MBS6287276

Product References and Citations for anti-CNOT2 antibody

Lau, N.C., et al. Biochem. J. 422(3):443-453(2009). Miyasaka, T., et al. Cancer Sci. 99(4):755-761(2008). Morita, M., et al. Mol. Cell. Biol. 27(13):4980-4990(2007). Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007). Matsuoka, S., et al. Science 316(5828):1160-1166(2007).

Other Notes

Small volumes of anti-CNOT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CNOT2 purchase

MBS6287276 is an antibody targeting CNOT2. Also known as CNOT2, ID (CNOT2, CDC36, NOT2, CCR4-NOT transcription complex subunit 2, CCR4-associated factor 2) (FITC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CNOT2. It may not necessarily be applicable to this product.

NCBI GI #
313482816
NCBI GeneID
4848
NCBI Accession #
NP_055330.1
UniProt Primary Accession #
Q9NZN8
UniProt Secondary Accession #
Q9H3E0; Q9NSX5; Q9NWR6; Q9P028
UniProt Related Accession #
Q9NZN8
GenBank Nucleotide #
NM_014515
NCBI Official Full Name
Homo sapiens CCR4-NOT transcription complex, subunit 2 (CNOT2), transcript variant 2, mRNA
NCBI Official Synonym Full Names
CCR4-NOT transcription complex, subunit 2
NCBI Official Symbol
CNOT2
NCBI Official Synonym Symbols
NOT2; CDC36; NOT2H; HSPC131
UniProt Protein Name
CCR4-NOT transcription complex subunit 2
UniProt Synonym Protein Names
CCR4-associated factor 2
Protein Family
CCR4-NOT transcription complex
UniProt Gene Name
CNOT2
UniProt Synonym Gene Names
CDC36; NOT2
UniProt Entry Name
CNOT2_HUMAN
NCBI Protein Information
CCR4-NOT transcription complex subunit 2; CCR4-associated factor 2; negative regulator of transcription 2

UniProt Comments for CNOT2

NOT2: The CCR4-NOT complex functions as general transcription regulation complex. Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8. Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. Belongs to the CNOT2/3/5 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: membrane; cytoplasm; nucleus; cytosol; CCR4-NOT complex

Molecular Function: protein binding; poly(A)-specific ribonuclease activity

Biological Process: regulation of transcription from RNA polymerase II promoter; regulation of translation; transcription from RNA polymerase II promoter; poly(A) tail shortening; gene expression; RNA-mediated gene silencing; negative regulation of transcription from RNA polymerase II promoter; negative regulation of estrogen receptor signaling pathway; mRNA catabolic process, deadenylation-dependent decay; trophectodermal cell differentiation
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Research Articles on CNOT2

1. The CNOT2-CNOT3 heterodimer is stabilized and tightly anchored to the surface of CNOT1 through an unexpected intertwined arrangement of peptide regions lacking defined secondary structure.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CNOT2 antibody

 Reference Product  PubMed Publications
 CNOT3 antibody  >5 publications with CNOT2 and CNOT3
 CNOT1 antibody  >5 publications with CNOT2 and CNOT1
 CNOT6 antibody  >2 publications with CNOT2 and CNOT6
 CNOT6L antibody  >1 publications with CNOT2 and CNOT6L
 CNOT4 antibody  >1 publications with CNOT2 and CNOT4
 CNOT8 antibody  >1 publications with CNOT2 and CNOT8

Pathways associated with anti-CNOT2 antibody

 Products by Pathway  Pathway Diagram
 Deadenylation Of MRNA Pathway antibodies  Deadenylation Of MRNA Pathway Diagram
 Deadenylation-dependent MRNA Decay Pathway antibodies  Deadenylation-dependent MRNA Decay Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram

Diseases associated with anti-CNOT2 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >1 publications with CNOT2 and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >1 publications with CNOT2 and Neoplasm Metastasis

Organs/Tissues associated with anti-CNOT2 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >2 publications with CNOT2 and Embryonic Tissue
 Brain Antibodies  >2 publications with CNOT2 and Brain
 Thyroid Antibodies  >1 publications with CNOT2 and Thyroid
 Salivary Gland Antibodies  >1 publications with CNOT2 and Salivary Gland
 Kidney Antibodies  >1 publications with CNOT2 and Kidney
 Uterus Antibodies  >1 publications with CNOT2 and Uterus
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