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COL17A1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8571021

This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
COL17A1, Polyclonal Antibody
Full Product Name
COL17A1 Polyclonal Antibody
Product Gene Name
anti-COL17A1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
Purity/Purification
Affinity Purification
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
142kDa; 150kDa
OMIM
113811
3D Structure
ModBase 3D Structure for Q9UMD9
Immunogen
A synthetic peptide of human COL17A1 (NP_000485.3).
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-COL17A1 antibody
Western Blot (WB)
Application Notes for anti-COL17A1 antibody
WB: 1:500-1:2000

Other Notes

Small volumes of anti-COL17A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for COL17A1 purchase

MBS8571021 is an antibody targeting COL17A1. Also known as COL17A1 Polyclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for COL17A1. It may not necessarily be applicable to this product.

NCBI GI #
119829187
NCBI GeneID
1308
NCBI Accession #
NP_000485.3
UniProt Primary Accession #
Q9UMD9
UniProt Related Accession #
Q9UMD9
GenBank Nucleotide #
NP_000485.3
NCBI Official Full Name
collagen alpha-1(XVII) chain
NCBI Official Synonym Full Names
collagen type XVII alpha 1 chain
NCBI Official Symbol
COL17A1
NCBI Official Synonym Symbols
ERED; BP180; BPA-2; BPAG2; LAD-1; BA16H23.2
UniProt Protein Name
Collagen alpha-1(XVII) chain
UniProt Synonym Protein Names
180 kDa bullous pemphigoid antigen 2; Bullous pemphigoid antigen 2Cleaved into the following 2 chains:120 kDa linear IgA disease antigen; Alternative name(s):; 120 kDa linear IgA dermatosis antigen; Linear IgA disease antigen 1; LAD-197 kDa linear IgA disease antigen; Alternative name(s):; 97 kDa linear IgA bullous dermatosis antigen; 97 kDa LAD antigen; 97-LAD; Linear IgA bullous disease antigen of 97 kDa
UniProt Gene Name
COL17A1
UniProt Synonym Gene Names
BP180; BPAG2; LAD-1; 97 kDa LAD antigen; 97-LAD; LABD97
UniProt Entry Name
COHA1_HUMAN
NCBI Protein Information
collagen alpha-1(XVII) chain

UniProt Comments for COL17A1

COL17A1: May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. Defects in COL17A1 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB). GABEB is a non- lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Extracellular matrix

Chromosomal Location of Human Ortholog: 10q24.3

Cellular Component: collagen; hemidesmosome; endoplasmic reticulum lumen; integral to plasma membrane; plasma membrane; extracellular region; basement membrane; intercellular junction

Molecular Function: protein binding

Biological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; epidermis development; hemidesmosome assembly; cell-matrix adhesion

Disease: Epidermolysis Bullosa, Junctional, Non-herlitz Type
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Research Articles on COL17A1

1. Hypomorphic COL17A1 variant associated with mild to moderate junctional epidermolysis bullosa.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-COL17A1 antibody

 Reference Product  PubMed Publications
 DST antibody  >17 publications with COL17A1 and DST
 LAMB3 antibody  >15 publications with COL17A1 and LAMB3
 LAMC2 antibody  >9 publications with COL17A1 and LAMC2
 ITGB4 antibody  >6 publications with COL17A1 and ITGB4
 COL7A1 antibody  >5 publications with COL17A1 and COL7A1
 PLEC antibody  >1 publications with COL17A1 and PLEC

Pathways associated with anti-COL17A1 antibody

 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Degradation Pathway antibodies  Collagen Degradation Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram

Diseases associated with anti-COL17A1 antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >49 publications with COL17A1 and Congenital Abnormalities
 Carcinoma, Squamous Cell Antibodies  >8 publications with COL17A1 and Carcinoma, Squamous Cell
 Neoplasms Antibodies  >5 publications with COL17A1 and Neoplasms
 Hyperplasia Antibodies  >2 publications with COL17A1 and Hyperplasia
 Melanoma Antibodies  >1 publications with COL17A1 and Melanoma
 Fetal Death Antibodies  >1 publications with COL17A1 and Fetal Death
 Nervous System Malformations Antibodies  >1 publications with COL17A1 and Nervous System Malformations
 Cell Transformation, Neoplastic Antibodies  >1 publications with COL17A1 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-COL17A1 antibody

 Organ/Tissue Name  Pubmed Publications
 Mouth Antibodies  >3 publications with COL17A1 and Mouth
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