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COPS7A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6011328

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of… More details

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Product Overview

Online Datasheet in PDF
Product Name
COPS7A, Polyclonal Antibody
Full Product Name
COPS7A, CT (COPS7A, CSN7A, DERP10, COP9 signalosome complex subunit 7a, Dermal papilla-derived protein 10, JAB1-containing signalosome subunit 7a)
Product Gene Name
anti-COPS7A antibody
Product Synonym Names
Anti -COPS7A, CT (COPS7A, CSN7A, DERP10, COP9 signalosome complex subunit 7a, Dermal papilla-derived protein 10, JAB1-containing signalosome subunit 7a)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
30,277 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (6833150..6841041). Location: 12p13.31
3D Structure
ModBase 3D Structure for Q9UBW8
Immunogen
COPS7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 244-274 amino acids from the C-terminal region of human COPS7A.

Product Categories/Family for anti-COPS7A antibody

Antibodies; Abs to Signal Transduction
Applications Tested/Suitable for anti-COPS7A antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-COPS7A antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-COPS7A antibody

COPS7A Antibody (C-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the COPS7A antibody detected the COPS7A protein (arrow).
Rabbit Anti-COPS7A Polyclonal Antibody – Cat# MBS6011328

Immunohistochemistry (IHC) of anti-COPS7A antibody

COPS7A Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of COPS7A Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-COPS7A Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6011328

Other Notes

Small volumes of anti-COPS7A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for COPS7A purchase

MBS6011328 is an antibody targeting COPS7A. Also known as COPS7A, CT (COPS7A, CSN7A, DERP10, COP9 signalosome complex subunit 7a, Dermal papilla-derived protein 10, JAB1-containing signalosome subunit 7a). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for COPS7A. It may not necessarily be applicable to this product.

NCBI GI #
62204486
NCBI GeneID
50813
NCBI Accession #
AAH93015.1
UniProt Primary Accession #
Q9UBW8
UniProt Secondary Accession #
Q9NVX3; Q9UJW4; A8K9A6
UniProt Related Accession #
Q9UBW8
NCBI Official Full Name
COPS7A protein
NCBI Official Synonym Full Names
COP9 signalosome subunit 7A
NCBI Official Symbol
COPS7A
NCBI Official Synonym Symbols
CSN7A
UniProt Protein Name
COP9 signalosome complex subunit 7a
UniProt Synonym Protein Names
Dermal papilla-derived protein 10; JAB1-containing signalosome subunit 7a
UniProt Gene Name
COPS7A
UniProt Synonym Gene Names
CSN7A; DERP10; SGN7a
UniProt Entry Name
CSN7A_HUMAN
NCBI Protein Information
COP9 signalosome complex subunit 7a; SGN7a; signalosome subunit 7a; COP9 complex subunit 7a; dermal papilla-derived protein 10; JAB1-containing signalosome subunit 7a; COP9 constitutive photomorphogenic homolog subunit 7A

NCBI Summary for COPS7A

This gene encodes a component of the COP9 signalosome, an evolutionarily conserved multi-subunit protease that regulates the activity of the ubiquitin conjugation pathway. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Mar 2014]

UniProt Comments for COPS7A

COPS7A: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Belongs to the CSN7/EIF3M family. CSN7 subfamily.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: nucleoplasm; signalosome; cytoplasm

Biological Process: cullin deneddylation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-COPS7A antibody

 Reference Product  PubMed Publications
 COPS5 antibody  >1 publications with COPS7A and COPS5

Diseases associated with anti-COPS7A antibody

 Disease Name  Pubmed Publications
 Prostatic Diseases Antibodies  >1 publications with COPS7A and Prostatic Diseases
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