• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

COX6B1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6288138

Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and… More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
COX6B1, Polyclonal Antibody
Full Product Name
COX6B1, CT (COX6B1, COX6B, Cytochrome c oxidase subunit 6B1, Cytochrome c oxidase subunit VIb isoform 1) (MaxLight 550)
Product Gene Name
anti-COX6B1 antibody
Product Synonym Names
COX6B1; COX6B; Cytochrome c oxidase subunit 6B1; Cytochrome c oxidase subunit VIb isoform 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
OMIM
gene 220110
3D Structure
ModBase 3D Structure for P14854
Immunogen
COX6B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the C-terminal region of human COX6B1.
Conjugate
MaxLight550
Note
Preservative Free

Product Categories/Family for anti-COX6B1 antibody

Antibodies; Enzymes; Cytochrome
Applications Tested/Suitable for anti-COX6B1 antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-COX6B1 antibody
IHC: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Product References and Citations for anti-COX6B1 antibody

Lazarou, M., et al. FEBS J. 276(22):6701-6713(2009). Massa, V., et al. Am. J. Hum. Genet. 82(6):1281-1289(2008). Sirchia, R., et al. Biol. Chem. 388(5):457-465(2007). Schmidt, T.R., et al. Gene 286(1):13-19(2002). Taanman, J.W., et al. Hum. Genet. 87(3):325-327(1991).

Other Notes

Small volumes of anti-COX6B1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for COX6B1 purchase

MBS6288138 is an antibody targeting COX6B1. Also known as COX6B1, CT (COX6B1, COX6B, Cytochrome c oxidase subunit 6B1, Cytochrome c oxidase subunit VIb isoform 1) (MaxLight 550). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for COX6B1. It may not necessarily be applicable to this product.

NCBI GI #
4502985
NCBI GeneID
1340
NCBI Accession #
NP_001854.1
UniProt Primary Accession #
P14854
UniProt Related Accession #
P14854
GenBank Nucleotide #
NM_001863.4
NCBI Official Full Name
cytochrome c oxidase subunit 6B1
NCBI Official Synonym Full Names
cytochrome c oxidase subunit 6B1
NCBI Official Symbol
COX6B1
NCBI Official Synonym Symbols
COXG; COX6B; COXVIb1
UniProt Protein Name
Cytochrome c oxidase subunit 6B1
UniProt Synonym Protein Names
Cytochrome c oxidase subunit VIb isoform 1; COX VIb-1
Protein Family
Cytochrome c oxidase
UniProt Gene Name
COX6B1
UniProt Synonym Gene Names
COX6B; COX VIb-1
UniProt Entry Name
CX6B1_HUMAN
NCBI Protein Information
cytochrome c oxidase subunit 6B1

UniProt Comments for COX6B1

COX6B1: Connects the two COX monomers into the physiological dimeric form. Defects in COX6B1 are a cause of mitochondrial complex IV deficiency (MT-C4D); also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome. Belongs to the cytochrome c oxidase subunit 6B family.

Protein type: Mitochondrial; Energy Metabolism - oxidative phosphorylation

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: mitochondrion; mitochondrial inner membrane; mitochondrial intermembrane space

Molecular Function: cytochrome-c oxidase activity

Biological Process: cellular metabolic process; substantia nigra development; transmembrane transport

Disease: Mitochondrial Complex Iv Deficiency
Show more

Research Articles on COX6B1

1. p2 peptide from HIV-1 enhances HIV-1 acute infection by increasing intracellular ATP production via the activation of mitochondrial cytochrome c oxidase (MT-CO) involved in the respiratory chain

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-COX6B1 antibody

 Reference Product  PubMed Publications
 COX6C antibody  >2 publications with COX6B1 and COX6C
 UQCRB antibody  >1 publications with COX6B1 and UQCRB
 COX7C antibody  >1 publications with COX6B1 and COX7C
 COX5B antibody  >1 publications with COX6B1 and COX5B

Pathways associated with anti-COX6B1 antibody

 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cytochrome C Oxidase Pathway antibodies  Cytochrome C Oxidase Pathway Diagram
 Cytochrome C Oxidase Pathway antibodies  Cytochrome C Oxidase Pathway Diagram
 Electron Transport Chain Pathway antibodies  Electron Transport Chain Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram

Diseases associated with anti-COX6B1 antibody

 Disease Name  Pubmed Publications
 Cytochrome-c Oxidase Deficiency Antibodies  >2 publications with COX6B1 and Cytochrome-c Oxidase Deficiency
 Neoplasm Metastasis Antibodies  >1 publications with COX6B1 and Neoplasm Metastasis
 Death Antibodies  >1 publications with COX6B1 and Death
 Brain Diseases Antibodies  >1 publications with COX6B1 and Brain Diseases
 Nervous System Diseases Antibodies  >1 publications with COX6B1 and Nervous System Diseases
 Fatty Liver Antibodies  >1 publications with COX6B1 and Fatty Liver

Organs/Tissues associated with anti-COX6B1 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >2 publications with COX6B1 and Muscle
 Lymph Node Antibodies  >1 publications with COX6B1 and Lymph Node
 Liver Antibodies  >1 publications with COX6B1 and Liver
 Brain Antibodies  >1 publications with COX6B1 and Brain
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000