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CPT1C Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6288506

The Cpt1 family of proteins are outer mitochondrial membrane proteins that regulate the entry into, and oxidation of fatty acids by, mitochondria. Malonyl-CoA, an intermediate in fatty acid synthesis, has been implicated as a regulatory component of the… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CPT1C, Polyclonal Antibody
Full Product Name
CPT1C, CT (CPT1C, CATL1, Carnitine O-palmitoyltransferase 1, brain isoform, CPT IC, Carnitine O-palmitoyltransferase I, brain isoform, Carnitine palmitoyltransferase 1C) (APC)
Product Gene Name
anti-CPT1C antibody
Product Synonym Names
CPT1C; CATL1; Carnitine O-palmitoyltransferase 1; brain isoform; CPT IC; Carnitine O-palmitoyltransferase I; brain isoform; Carnitine palmitoyltransferase 1C
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
81,000 Da
OMIM
608846
3D Structure
ModBase 3D Structure for Q8TCG5
Immunogen
CPT1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 584-614 amino acids from the C-terminal region of human CPT1C.
Conjugate
APC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-CPT1C antibody

Antibodies; Enzymes
Applications Tested/Suitable for anti-CPT1C antibody
Western Blot (WB), FLISA
Application Notes for anti-CPT1C antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CPT1C antibody

CPT1C Antibody (C-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the CPT1C antibody detected the CPT1C protein (arrow).
Rabbit Anti-CPT1C Polyclonal Antibody – Cat# MBS6288506

Product References and Citations for anti-CPT1C antibody

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Roomets, E., et al. Invest. Ophthalmol. Vis. Sci. 49(4):1660-1664(2008). Sierra, A.Y., et al. J. Biol. Chem. 283(11):6878-6885(2008). Price, N., et al. Genomics 80(4):433-442(2002).

Other Notes

Small volumes of anti-CPT1C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CPT1C purchase

MBS6288506 is an antibody targeting CPT1C. Also known as CPT1C, CT (CPT1C, CATL1, Carnitine O-palmitoyltransferase 1, brain isoform, CPT IC, Carnitine O-palmitoyltransferase I, brain isoform, Carnitine palmitoyltransferase 1C) (APC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CPT1C. It may not necessarily be applicable to this product.

NCBI GI #
209862905
NCBI GeneID
126129
NCBI Accession #
NP_001129524.1
NCBI Related Accession #
NP_689572.1
UniProt Primary Accession #
Q8TCG5
UniProt Secondary Accession #
Q5K6N5; Q8N6Q9; Q8NDS6; Q8TE84; A8K0Z8
UniProt Related Accession #
Q8TCG5
GenBank Nucleotide #
NM_001136052.2
NCBI Official Full Name
carnitine O-palmitoyltransferase 1, brain isoform isoform 1
NCBI Official Synonym Full Names
carnitine palmitoyltransferase 1C
NCBI Official Symbol
CPT1C
NCBI Official Synonym Symbols
CATL1; CPT1P; CPTIC; SPG73; CPT1-B; CPTI-B
UniProt Protein Name
Carnitine O-palmitoyltransferase 1, brain isoform
UniProt Synonym Protein Names
CPT IC; Carnitine O-palmitoyltransferase I, brain isoform; CPTI-B; Carnitine palmitoyltransferase 1C
Protein Family
Carnitine O-palmitoyltransferase
UniProt Gene Name
CPT1C
UniProt Synonym Gene Names
CATL1; CPT1-B; CPTI-B
UniProt Entry Name
CPT1C_HUMAN
NCBI Protein Information
carnitine O-palmitoyltransferase 1, brain isoform

NCBI Summary for CPT1C

This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein regulates the beta-oxidation and transport of long-chain fatty acids into mitochondria, and may play a role in the regulation of feeding behavior and whole-body energy homeostasis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
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UniProt Comments for CPT1C

CPT1C: a member of the carnitine/choline acetyltransferase family. The encoded protein regulates the beta-oxidation and transport of long-chain fatty acids into mitochondria, and may play a role in the regulation of feeding behavior and whole-body energy homeostasis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Protein type: Lipid Metabolism - fatty acid; Membrane protein, multi-pass; Membrane protein, integral; Transferase; EC 2.3.1.21

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: endoplasmic reticulum membrane; mitochondrial outer membrane; synapse; cell junction

Molecular Function: carnitine O-palmitoyltransferase activity

Biological Process: fatty acid beta-oxidation; carnitine metabolic process

Disease: Spastic Paraplegia 73, Autosomal Dominant
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Research Articles on CPT1C

1. Depletion of PPARalpha resulted in low CPT1C expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CPT1C antibody

 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram

Diseases associated with anti-CPT1C antibody

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >7 publications with CPT1C and Fatty Liver
 Weight Gain Antibodies  >5 publications with CPT1C and Weight Gain
 Nervous System Diseases Antibodies  >3 publications with CPT1C and Nervous System Diseases
 Neoplasms Antibodies  >3 publications with CPT1C and Neoplasms
 Liver Diseases Antibodies  >2 publications with CPT1C and Liver Diseases
 Drug Toxicity Antibodies  >1 publications with CPT1C and Drug Toxicity
 Lung Neoplasms Antibodies  >1 publications with CPT1C and Lung Neoplasms
 Breast Neoplasms Antibodies  >1 publications with CPT1C and Breast Neoplasms
 Congenital Abnormalities Antibodies  >1 publications with CPT1C and Congenital Abnormalities
 Microcephaly Antibodies  >1 publications with CPT1C and Microcephaly

Organs/Tissues associated with anti-CPT1C antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with CPT1C and Brain
 Muscle Antibodies  >5 publications with CPT1C and Muscle
 Eye Antibodies  >2 publications with CPT1C and Eye
 Heart Antibodies  >1 publications with CPT1C and Heart
 Uterus Antibodies  >1 publications with CPT1C and Uterus
 Lung Antibodies  >1 publications with CPT1C and Lung
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