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CRABP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6288572

A number of specific carrier proteins for members of the vitamin A family have been discovered. Cellular retinoic acid binding proteins (CRABP) are low molecular weight proteins whose precise function remains unknown. The inducibility of the CRABP2 gene… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CRABP2, Polyclonal Antibody
Full Product Name
CRABP2, CT (CRABP2, Cellular retinoic acid-binding protein 2, Cellular retinoic acid-binding protein II) (APC)
Product Gene Name
anti-CRABP2 antibody
Product Synonym Names
CRABP2; Cellular retinoic acid-binding protein 2; Cellular retinoic acid-binding protein II
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
15,693 Da
OMIM
180231
3D Structure
ModBase 3D Structure for P29373
Immunogen
CRABP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-116 amino acids from the C-terminal region of human CRABP2.
Conjugate
APC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-CRABP2 antibody

Antibodies; Binding Proteins
Applications Tested/Suitable for anti-CRABP2 antibody
Western Blot (WB), FLISA
Application Notes for anti-CRABP2 antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CRABP2 antibody

CRABP2 Antibody (C-term) western blot analysis MDA-MB453 cell line lysates (35ug/lane).This demonstrates the CRABP2 antibody detected the CRABP2 protein (arrow).
Rabbit Anti-CRABP2 Polyclonal Antibody – Cat# MBS6288572

Western Blot (WB) of anti-CRABP2 antibody

Western blot analysis of CRABP2 (arrow) using rabbit polyclonal CRABP2 Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CRABP2 gene.
Rabbit Anti-CRABP2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6288572

Product References and Citations for anti-CRABP2 antibody

Sola, R., et al. Atherosclerosis 211(2):630-637(2010). Manolescu, D.C., et al. Pediatr. Res. 67(6):598-602(2010). Calmon, M.F., et al. Neoplasia 11(12):1329-1339(2009). Corlazzoli, F., et al. PLoS ONE 4 (1), E4305 (2009): Gupta, A., et al. Exp. Cell Res. 314(20):3663-3668(2008).

Other Notes

Small volumes of anti-CRABP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CRABP2 purchase

MBS6288572 is an antibody targeting CRABP2. Also known as CRABP2, CT (CRABP2, Cellular retinoic acid-binding protein 2, Cellular retinoic acid-binding protein II) (APC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CRABP2. It may not necessarily be applicable to this product.

NCBI GI #
4503029
NCBI GeneID
1382
NCBI Accession #
NP_001869.1
UniProt Primary Accession #
P29373
UniProt Secondary Accession #
Q6ICN6; B2R4Z8; D3DVC5; F1T098
UniProt Related Accession #
P29373
GenBank Nucleotide #
NM_001878.3
NCBI Official Full Name
cellular retinoic acid-binding protein 2
NCBI Official Synonym Full Names
cellular retinoic acid binding protein 2
NCBI Official Symbol
CRABP2
NCBI Official Synonym Symbols
RBP6; CRABP-II
UniProt Protein Name
Cellular retinoic acid-binding protein 2
UniProt Synonym Protein Names
Cellular retinoic acid-binding protein II
Protein Family
Cellular retinoic acid-binding protein
UniProt Gene Name
CRABP2
UniProt Synonym Gene Names
CRABP-II
UniProt Entry Name
RABP2_HUMAN
NCBI Protein Information
cellular retinoic acid-binding protein 2; cellular retinoic acid-binding protein II

NCBI Summary for CRABP2

This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010]
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UniProt Comments for CRABP2

CRABP2: Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Protein type: Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: nucleoplasm; endoplasmic reticulum; cytoplasm; cytosol

Molecular Function: retinoid binding; retinoic acid binding; transporter activity; retinal binding; retinol binding

Biological Process: embryonic forelimb morphogenesis; epidermis development; regulation of transcription, DNA-dependent; retinoic acid metabolic process; signal transduction; transmembrane transport
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Research Articles on CRABP2

1. Reengineering of cellular retinoic acid binding protein II (CRABPII) to be capable of binding retinal as a protonated Schiff base is described

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CRABP2 antibody

 Reference Product  PubMed Publications
 RARS antibody  >5 publications with CRABP2 and RARS
 ALDH1A1 antibody  >3 publications with CRABP2 and ALDH1A1
 APAF1 antibody  >1 publications with CRABP2 and APAF1

Pathways associated with anti-CRABP2 antibody

 Products by Pathway  Pathway Diagram
 Orphan Transporters Pathway antibodies  Orphan Transporters Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Retinoic Acid Pathway antibodies  Signaling By Retinoic Acid Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Vitamin A And Carotenoid Metabolism Pathway antibodies  Vitamin A And Carotenoid Metabolism Pathway Diagram

Diseases associated with anti-CRABP2 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >21 publications with CRABP2 and Carcinoma
 Adenocarcinoma Antibodies  >9 publications with CRABP2 and Adenocarcinoma
 Kidney Diseases Antibodies  >5 publications with CRABP2 and Kidney Diseases
 Nervous System Diseases Antibodies  >5 publications with CRABP2 and Nervous System Diseases
 Carcinoma, Squamous Cell Antibodies  >5 publications with CRABP2 and Carcinoma, Squamous Cell
 Breast Neoplasms Antibodies  >4 publications with CRABP2 and Breast Neoplasms
 Lung Diseases Antibodies  >4 publications with CRABP2 and Lung Diseases
 Lung Neoplasms Antibodies  >3 publications with CRABP2 and Lung Neoplasms
 Ovarian Neoplasms Antibodies  >3 publications with CRABP2 and Ovarian Neoplasms
 Inflammation Antibodies  >3 publications with CRABP2 and Inflammation

Organs/Tissues associated with anti-CRABP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Uterus Antibodies  >12 publications with CRABP2 and Uterus
 Embryonic Tissue Antibodies  >10 publications with CRABP2 and Embryonic Tissue
 Skin Antibodies  >9 publications with CRABP2 and Skin
 Muscle Antibodies  >7 publications with CRABP2 and Muscle
 Blood Antibodies  >7 publications with CRABP2 and Blood
 Brain Antibodies  >6 publications with CRABP2 and Brain
 Kidney Antibodies  >6 publications with CRABP2 and Kidney
 Bone Antibodies  >5 publications with CRABP2 and Bone
 Lung Antibodies  >4 publications with CRABP2 and Lung
 Connective Tissue Antibodies  >4 publications with CRABP2 and Connective Tissue
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