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CRFR2D Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6288794

Liaw et al. (1996) [PubMed 8536644] stated that there are 2 G protein-coupled corticotropin-releasing hormone (CRH; MIM 122560) receptors, CRHR1 (MIM 122561) and CRHR2, which they termed the CRF2 receptor. CRH is a 41-amino acid peptide synthesized in the… More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CRFR2D, Polyclonal Antibody
Full Product Name
CRFR2D (Corticotropin-releasing factor receptor 2,CRHR2,CRF2R, CRH2R) (FITC)
Product Gene Name
anti-CRFR2D antibody
Product Synonym Gene Name
CRHR2
Product Synonym Names
Corticotropin-releasing factor receptor 2,CRHR2,CRF2R; CRH2R
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
47,688 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (30691559..30739719, complement). Location: 7p14.3
3D Structure
ModBase 3D Structure for B3SXS6
Immunogen
CRFR2D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the human CRFR2D.
Conjugate
FITC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-CRFR2D antibody

Antibodies; Receptors
Applications Tested/Suitable for anti-CRFR2D antibody
Flow Cytometry (FC/FACS), FLISA, Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-CRFR2D antibody
FC/FACS: 1:10-50
FLISA: 1:1,000
IHC: 1:50-100
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CRFR2D antibody

CRFR2D Antibody western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the CRFR2D antibody detected the CRFR2D protein (arrow).
Rabbit Anti-CRFR2D Polyclonal Antibody – Cat# MBS6288794

Immunohistochemistry (IHC) of anti-CRFR2D antibody

CRFR2D Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CRFR2D Antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-CRFR2D Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6288794

Flow Cytometry (FC/FACS) of anti-CRFR2D antibody

CRFR2D Antibody flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CRFR2D Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6288794

Product References and Citations for anti-CRFR2D antibody

Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010): Gutknecht, E., et al. Eur. J. Pharmacol. 642 (1-3), 1-9 (2010): Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010). Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010): Joubert, B.R., et al. Genome Med 2 (3), 17 (2010).

Other Notes

Small volumes of anti-CRFR2D antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CRFR2D purchase

MBS6288794 is an antibody targeting CRFR2D. Also known as CRFR2D (Corticotropin-releasing factor receptor 2,CRHR2,CRF2R, CRH2R) (FITC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CRFR2D. It may not necessarily be applicable to this product.

NCBI GI #
321117257
NCBI GeneID
1395
NCBI Accession #
NP_001189412.1
UniProt Primary Accession #
B3SXS6
UniProt Secondary Accession #
O43461; Q4QRJ4; Q99431
UniProt Related Accession #
Q13324
GenBank Nucleotide #
NM_001202483.1
NCBI Official Full Name
corticotropin-releasing factor receptor 2 isoform 5
NCBI Official Synonym Full Names
corticotropin releasing hormone receptor 2
NCBI Official Symbol
CRHR2
NCBI Official Synonym Symbols
CRF2; CRFR2; CRF-RB; HM-CRF
NCBI Protein Information
corticotropin-releasing factor receptor 2; CRH-R2; CRF2 receptor, beta isoform

NCBI Summary for CRFR2D

The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]
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Research Articles on CRFR2D

1. Polymorphisms within CRHR1 and CRHR2 genes interacted with both childhood sexual abuse and emotional neglect to influence Iowa Gambling Task performance.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CRFR2D antibody

 Reference Product  PubMed Publications
 CRH antibody  >66 publications with CRFR2D and CRH
 UCN antibody  >19 publications with CRFR2D and UCN
 UCN3 antibody  >9 publications with CRFR2D and UCN3
 POMC antibody  >9 publications with CRFR2D and POMC
 UCN2 antibody  >6 publications with CRFR2D and UCN2
 GHRHR antibody  >1 publications with CRFR2D and GHRHR

Pathways associated with anti-CRFR2D antibody

 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class B Secretin-like Pathway antibodies  GPCRs, Class B Secretin-like Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-CRFR2D antibody

 Disease Name  Pubmed Publications
 Anxiety Disorders Antibodies  >12 publications with CRFR2D and Anxiety Disorders
 Inflammation Antibodies  >7 publications with CRFR2D and Inflammation
 Weight Gain Antibodies  >4 publications with CRFR2D and Weight Gain
 Depressive Disorder Antibodies  >4 publications with CRFR2D and Depressive Disorder
 Disease Models, Animal Antibodies  >4 publications with CRFR2D and Disease Models, Animal
 Neoplasms Antibodies  >4 publications with CRFR2D and Neoplasms
 Weight Loss Antibodies  >3 publications with CRFR2D and Weight Loss
 Cardiovascular Diseases Antibodies  >3 publications with CRFR2D and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with CRFR2D and Carcinoma, Hepatocellular
 Hypertension Antibodies  >3 publications with CRFR2D and Hypertension

Organs/Tissues associated with anti-CRFR2D antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >45 publications with CRFR2D and Brain
 Uterus Antibodies  >1 publications with CRFR2D and Uterus
 Testis Antibodies  >1 publications with CRFR2D and Testis
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