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CRH Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6288806

Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CRH, Polyclonal Antibody
Full Product Name
CRH, CT (CRH, Corticoliberin, Corticotropin-releasing factor, Corticotropin-releasing hormone) (Azide free) (HRP)
Product Gene Name
anti-CRH antibody
Product Synonym Names
CRH; Corticoliberin; Corticotropin-releasing factor; Corticotropin-releasing hormone
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
21,422 Da
Chromosome Location
Chromosome: 8; NC_000008.10 (67088612..67090846, complement). Location: 8q13
OMIM
122560
3D Structure
ModBase 3D Structure for P06850
Immunogen
CRH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-164 amino acids from the C-terminal region of human CRH.
Conjugate
HRP
Note
Preservative Free

Product Categories/Family for anti-CRH antibody

Antibodies; Hormones; Steroids
Applications Tested/Suitable for anti-CRH antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CRH antibody
WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CRH antibody

Western blot analysis of CRH (arrow) using rabbit polyclonal CRH Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CRH gene.
Rabbit Anti-CRH Polyclonal Antibody – Cat# MBS6288806

Product References and Citations for anti-CRH antibody

Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010). Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010): Holliday, K.L., et al. J Psychosom Res 68(5):469-474(2010). Binder, E.B., et al. Arch. Gen. Psychiatry 67(4):369-379(2010). Kageyama, K., et al. Vitam. Horm. 82, 301-317 (2010).

Other Notes

Small volumes of anti-CRH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CRH purchase

MBS6288806 is an antibody targeting CRH. Also known as CRH, CT (CRH, Corticoliberin, Corticotropin-releasing factor, Corticotropin-releasing hormone) (Azide free) (HRP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CRH. It may not necessarily be applicable to this product.

NCBI GI #
4503041
NCBI GeneID
1392
NCBI Accession #
NP_000747.1
UniProt Primary Accession #
P06850
UniProt Secondary Accession #
B3KQS4
UniProt Related Accession #
P06850
GenBank Nucleotide #
NM_000756.2
NCBI Official Full Name
corticoliberin preproprotein
NCBI Official Synonym Full Names
corticotropin releasing hormone
NCBI Official Symbol
CRH
NCBI Official Synonym Symbols
CRF
UniProt Protein Name
Corticoliberin
UniProt Synonym Protein Names
Corticotropin-releasing factor; CRF; Corticotropin-releasing hormone
Protein Family
Corticoliberin
UniProt Gene Name
CRH
UniProt Synonym Gene Names
CRF
UniProt Entry Name
CRF_HUMAN
NCBI Protein Information
corticoliberin; corticotropin-releasing factor

UniProt Comments for CRH

CRH: This hormone from hypothalamus regulates the release of corticotropin from pituitary gland. Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8q13

Cellular Component: extracellular space; cytoplasm; extracellular region; perikaryon

Molecular Function: corticotropin-releasing hormone receptor 1 binding; neuropeptide hormone activity; protein binding; hormone activity; corticotropin-releasing hormone receptor 2 binding; adrenocorticotropin-releasing hormone activity; receptor binding

Biological Process: diterpenoid metabolic process; negative regulation of circadian sleep/wake cycle, REM sleep; synaptic transmission, dopaminergic; hypothalamus development; positive regulation of cortisol secretion; induction of apoptosis by hormones; response to pain; female pregnancy; signal transduction; positive regulation of adrenocorticotropic hormone secretion; negative regulation of luteinizing hormone secretion; synaptic transmission; learning and/or memory; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; feeding behavior; parturition; negative regulation of blood pressure; inflammatory response; response to electrical stimulus; associative learning; response to corticosterone stimulus; response to drug; adrenal gland development; response to ether; response to ethanol; long-term memory; ion homeostasis; response to estrogen stimulus; regulation of serotonin secretion; negative regulation of epinephrine secretion; positive regulation of protein amino acid phosphorylation; glucocorticoid biosynthetic process; lung development

Disease: Acth Deficiency, Isolated
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CRH antibody

 Reference Product  PubMed Publications
 POMC antibody  >2214 publications with CRH and POMC
 AVP antibody  >537 publications with CRH and AVP
 NPY antibody  >181 publications with CRH and NPY
 CRHR1 antibody  >176 publications with CRH and CRHR1
 GHRH antibody  >156 publications with CRH and GHRH
 UCN antibody  >96 publications with CRH and UCN
 CRHR2 antibody  >79 publications with CRH and CRHR2
 ADCYAP1 antibody  >15 publications with CRH and ADCYAP1
 MC4R antibody  >12 publications with CRH and MC4R

Pathways associated with anti-CRH antibody

 Products by Pathway  Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Long-term Depression Pathway antibodies  Long-term Depression Pathway Diagram
 Long-term Depression Pathway antibodies  Long-term Depression Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Rapid Glucocorticoid Signaling Pathway antibodies  Rapid Glucocorticoid Signaling Pathway Diagram

Diseases associated with anti-CRH antibody

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >678 publications with CRH and Mental Disorders
 Nervous System Diseases Antibodies  >651 publications with CRH and Nervous System Diseases
 Brain Diseases Antibodies  >516 publications with CRH and Brain Diseases
 Cushing Syndrome Antibodies  >371 publications with CRH and Cushing Syndrome
 Depressive Disorder Antibodies  >330 publications with CRH and Depressive Disorder
 Inflammation Antibodies  >253 publications with CRH and Inflammation
 Anxiety Disorders Antibodies  >235 publications with CRH and Anxiety Disorders
 Necrosis Antibodies  >134 publications with CRH and Necrosis
 Hypertension Antibodies  >120 publications with CRH and Hypertension
 Pain Antibodies  >100 publications with CRH and Pain

Organs/Tissues associated with anti-CRH antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3253 publications with CRH and Brain
 Adrenal Gland Antibodies  >790 publications with CRH and Adrenal Gland
 Placenta Antibodies  >280 publications with CRH and Placenta
 Muscle Antibodies  >152 publications with CRH and Muscle
 Embryonic Tissue Antibodies  >127 publications with CRH and Embryonic Tissue
 Uterus Antibodies  >120 publications with CRH and Uterus
 Connective Tissue Antibodies  >47 publications with CRH and Connective Tissue
 Pancreas Antibodies  >19 publications with CRH and Pancreas
 Uncharacterized Tissue Antibodies  >1 publications with CRH and Uncharacterized Tissue
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