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CRHBP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6013217

Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CRHBP, Polyclonal Antibody
Full Product Name
CRHBP (Corticotropin-releasing Hormone-binding Protein, CRH-BP, Corticotropin-Releasing Factor-binding Protein, CRF-binding Protein, CRF-BP, CRFBP)
Product Gene Name
anti-CRHBP antibody
Product Synonym Names
Anti -CRHBP (Corticotropin-releasing Hormone-binding Protein, CRH-BP, Corticotropin-Releasing Factor-binding Protein, CRF-binding Protein, CRF-BP, CRFBP)
Immunogen Sequence
MSPNFKLQCH FILIFLTALR GESRYLELRE AADYDPFLLF SANLKRELAG EQPYRRALRC LDMLSLQGQF TFTADRPQLH CAAFFISEPE EFITIHYDQV SIDCQGGDFL KVFDGWILKG EKFPSSQDHP LPSAERYIDF CESGLSRRSI RSSQNVAMIF FRVHEPGNGF TLTIKTDPNL FPCNVISQTP NGKFTLVVPH QHRNCSFSII YPVVIKISDL TLGHVNGLQL KKSSAGCEGI GDFVELLGGT GLDPSKMTPL ADLCYPFHGP AQMKVGCDNT VVRMVSSGKH VNRVTFEYRQ LEPYELENPN GNSIGEFCLS GL
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid.
Purity/Purification
Serum
Serum
Specificity
Recognizes human CRHBP.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Chromosome Location
Chromosome: 5; NC_000005.9 (76248680..76265299). Location: 5q11.2-q13.3
OMIM
122559
3D Structure
ModBase 3D Structure for P24387
Immunogen
Full length recombinant protein corresponding to aa1-322 of human CRHBP

Product Categories/Family for anti-CRHBP antibody

Antibodies; Abs to Binding Proteins
Applications Tested/Suitable for anti-CRHBP antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-CRHBP antibody
Suitable for use in Western Blot and Immunoprecipitation.

Western Blot (WB) of anti-CRHBP antibody

Western Blot analysis of CRHBP expression in human colon using MBS6013217.
Rabbit Anti-CRHBP Polyclonal Antibody – Cat# MBS6013217

Western Blot (WB) of anti-CRHBP antibody

Western Blot analysis of CRHBP expression in transfected 293T cell line using MBS6013217.
Lane 1: CRHBP transfected lysate (36.1kD).
Lane 2: Non-transfected lysate
Rabbit Anti-CRHBP Polyclonal Antibody, Western Blot (WB) – Cat# MBS6013217

Immunoprecipitation (IP) of anti-CRHBP antibody

Immunoprecipitation of CRHBP transfected lysate using using MBS6013217 and Protein A Magnetic Bead and immunoblotted with CRHBP mouse polyclonal antibody.
Rabbit Anti-CRHBP Polyclonal Antibody, Immunoprecipitation (IP) – Cat# MBS6013217

Other Notes

Small volumes of anti-CRHBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CRHBP purchase

MBS6013217 is an antibody targeting CRHBP. Also known as CRHBP (Corticotropin-releasing Hormone-binding Protein, CRH-BP, Corticotropin-Releasing Factor-binding Protein, CRF-binding Protein, CRF-BP, CRFBP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CRHBP. It may not necessarily be applicable to this product.

NCBI GI #
47080099
NCBI GeneID
1393
NCBI Accession #
NP_001873.2
UniProt Primary Accession #
P24387
UniProt Secondary Accession #
Q53F32; Q6FHT5
UniProt Related Accession #
P24387
GenBank Nucleotide #
NM_001882.3
NCBI Official Full Name
corticotropin-releasing factor-binding protein
NCBI Official Synonym Full Names
corticotropin releasing hormone binding protein
NCBI Official Symbol
CRHBP
NCBI Official Synonym Symbols
CRFBP; CRF-BP
UniProt Protein Name
Corticotropin-releasing factor-binding protein
UniProt Synonym Protein Names
Corticotropin-releasing hormone-binding protein
Protein Family
Corticotropin-releasing factor-binding protein
UniProt Gene Name
CRHBP
UniProt Synonym Gene Names
CRFBP; CRF-BP; CRF-binding protein; CRH-BP
UniProt Entry Name
CRHBP_HUMAN
NCBI Protein Information
corticotropin-releasing factor-binding protein; CRH-BP; CRF-binding protein; corticotropin releasing hormone-binding protein; corticotropin-releasing hormone-binding protein

NCBI Summary for CRHBP

Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]
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UniProt Comments for CRHBP

CRHBP: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.

Protein type: Secreted; Secreted, signal peptide; Inhibitor

Chromosomal Location of Human Ortholog: 5q13.3

Cellular Component: multivesicular body; Golgi apparatus; extracellular space; microtubule; endoplasmic reticulum; dendrite; perikaryon; intracellular; nerve terminal; nucleus; secretory granule

Molecular Function: protein binding; corticotropin-releasing hormone binding; peptide binding

Biological Process: negative regulation of adrenocorticotropic hormone secretion; synaptic transmission, dopaminergic; regulated secretory pathway; learning and/or memory; hormone-mediated signaling; cellular response to stress; regulation of adrenocorticotropin hormone secretion; hormone metabolic process; female pregnancy; behavioral response to ethanol; signal transduction; inflammatory response
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Research Articles on CRHBP

1. Significant main effects on children's cortisol reactivity were found for loci on CRHR1 and CRHBP.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CRHBP antibody

 Reference Product  PubMed Publications
 CRH antibody  >28 publications with CRHBP and CRH
 CRHR1 antibody  >16 publications with CRHBP and CRHR1
 CRHR2 antibody  >9 publications with CRHBP and CRHR2
 POMC antibody  >6 publications with CRHBP and POMC
 UCN antibody  >6 publications with CRHBP and UCN
 UCN2 antibody  >3 publications with CRHBP and UCN2

Diseases associated with anti-CRHBP antibody

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >9 publications with CRHBP and Mental Disorders
 Depressive Disorder Antibodies  >4 publications with CRHBP and Depressive Disorder
 Inflammation Antibodies  >3 publications with CRHBP and Inflammation
 Pain Antibodies  >3 publications with CRHBP and Pain
 Disease Models, Animal Antibodies  >2 publications with CRHBP and Disease Models, Animal
 Necrosis Antibodies  >2 publications with CRHBP and Necrosis
 Premature Birth Antibodies  >2 publications with CRHBP and Premature Birth
 Nervous System Diseases Antibodies  >1 publications with CRHBP and Nervous System Diseases
 Edema Antibodies  >1 publications with CRHBP and Edema

Organs/Tissues associated with anti-CRHBP antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >12 publications with CRHBP and Brain
 Kidney Antibodies  >4 publications with CRHBP and Kidney
 Placenta Antibodies  >4 publications with CRHBP and Placenta
 Ovary Antibodies  >3 publications with CRHBP and Ovary
 Skin Antibodies  >3 publications with CRHBP and Skin
 Embryonic Tissue Antibodies  >2 publications with CRHBP and Embryonic Tissue
 Adrenal Gland Antibodies  >2 publications with CRHBP and Adrenal Gland
 Liver Antibodies  >2 publications with CRHBP and Liver
 Connective Tissue Antibodies  >1 publications with CRHBP and Connective Tissue
 Uterus Antibodies  >1 publications with CRHBP and Uterus
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