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CRHBP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6288813

Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CRHBP, Polyclonal Antibody
Full Product Name
CRHBP, NT (CRHBP, CRFBP, Corticotropin-releasing factor-binding protein, Corticotropin-releasing hormone-binding protein) (AP)
Product Gene Name
anti-CRHBP antibody
Product Synonym Names
CRHBP; CRFBP; Corticotropin-releasing factor-binding protein; Corticotropin-releasing hormone-binding protein
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase.
Purity/Purification
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
36,144 Da
OMIM
122559
3D Structure
ModBase 3D Structure for P24387
Immunogen
CRHBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-36 amino acids from the N-terminal region of human CRHBP.
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-CRHBP antibody

Antibodies; Binding Proteins
Applications Tested/Suitable for anti-CRHBP antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CRHBP antibody
WB: 1:50-100
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CRHBP antibody

Western blot analysis of CRHBP (arrow) using rabbit polyclonal CRHBP Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CRHBP gene.
Rabbit Anti-CRHBP Polyclonal Antibody – Cat# MBS6288813

Product References and Citations for anti-CRHBP antibody

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Holliday, K.L., et al. J Psychosom Res 68(5):469-474(2010). Binder, E.B., et al. Arch. Gen. Psychiatry 67(4):369-379(2010). Bosker, F.J., et al. Mol. Psychiatry (2010). In press: Tabakoff, B., et al. BMC Biol. 7, 70 (2009).

Other Notes

Small volumes of anti-CRHBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CRHBP purchase

MBS6288813 is an antibody targeting CRHBP. Also known as CRHBP, NT (CRHBP, CRFBP, Corticotropin-releasing factor-binding protein, Corticotropin-releasing hormone-binding protein) (AP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CRHBP. It may not necessarily be applicable to this product.

NCBI GI #
47080099
NCBI GeneID
1393
NCBI Accession #
NP_001873.2
UniProt Primary Accession #
P24387
UniProt Secondary Accession #
Q53F32; Q6FHT5
UniProt Related Accession #
P24387
GenBank Nucleotide #
NM_001882.3
NCBI Official Full Name
corticotropin-releasing factor-binding protein
NCBI Official Synonym Full Names
corticotropin releasing hormone binding protein
NCBI Official Symbol
CRHBP
NCBI Official Synonym Symbols
CRFBP; CRF-BP
UniProt Protein Name
Corticotropin-releasing factor-binding protein
UniProt Synonym Protein Names
Corticotropin-releasing hormone-binding protein; CRH-BP
Protein Family
Corticotropin-releasing factor-binding protein
UniProt Gene Name
CRHBP
UniProt Synonym Gene Names
CRFBP; CRF-BP; CRF-binding protein; CRH-BP
UniProt Entry Name
CRHBP_HUMAN
NCBI Protein Information
corticotropin-releasing factor-binding protein; CRF-binding protein; CRH-BP; corticotropin releasing hormone-binding protein; corticotropin-releasing hormone-binding protein

UniProt Comments for CRHBP

CRHBP: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.

Protein type: Secreted, signal peptide; Inhibitor; Secreted

Chromosomal Location of Human Ortholog: 5q13.3

Cellular Component: Golgi apparatus; multivesicular body; extracellular space; microtubule; endoplasmic reticulum; dendrite; perikaryon; intracellular; nerve terminal; nucleus; secretory granule

Molecular Function: protein binding; corticotropin-releasing hormone binding; peptide binding

Biological Process: negative regulation of adrenocorticotropic hormone secretion; regulated secretory pathway; synaptic transmission, dopaminergic; learning and/or memory; hormone-mediated signaling; cellular response to stress; regulation of adrenocorticotropin hormone secretion; hormone metabolic process; female pregnancy; behavioral response to ethanol; inflammatory response; signal transduction
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Research Articles on CRHBP

1. Homozygosity for the CRHBP rs10055255 T allele was associated with significantly fewer post-ICU PTSD and depressive symptoms

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CRHBP antibody

 Reference Product  PubMed Publications
 CRH antibody  >31 publications with CRHBP and CRH
 CRHR1 antibody  >18 publications with CRHBP and CRHR1
 CRHR2 antibody  >11 publications with CRHBP and CRHR2
 POMC antibody  >7 publications with CRHBP and POMC
 UCN antibody  >7 publications with CRHBP and UCN
 UCN2 antibody  >4 publications with CRHBP and UCN2

Pathways associated with anti-CRHBP antibody

 Products by Pathway  Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram

Diseases associated with anti-CRHBP antibody

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >11 publications with CRHBP and Mental Disorders
 Depressive Disorder Antibodies  >5 publications with CRHBP and Depressive Disorder
 Pain Antibodies  >3 publications with CRHBP and Pain
 Inflammation Antibodies  >3 publications with CRHBP and Inflammation
 Hypertension Antibodies  >2 publications with CRHBP and Hypertension
 Premature Birth Antibodies  >2 publications with CRHBP and Premature Birth
 Disease Models, Animal Antibodies  >2 publications with CRHBP and Disease Models, Animal
 Necrosis Antibodies  >2 publications with CRHBP and Necrosis
 Edema Antibodies  >1 publications with CRHBP and Edema
 Adenocarcinoma Antibodies  >1 publications with CRHBP and Adenocarcinoma

Organs/Tissues associated with anti-CRHBP antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with CRHBP and Brain
 Kidney Antibodies  >5 publications with CRHBP and Kidney
 Placenta Antibodies  >4 publications with CRHBP and Placenta
 Ovary Antibodies  >3 publications with CRHBP and Ovary
 Skin Antibodies  >3 publications with CRHBP and Skin
 Liver Antibodies  >3 publications with CRHBP and Liver
 Embryonic Tissue Antibodies  >2 publications with CRHBP and Embryonic Tissue
 Adrenal Gland Antibodies  >2 publications with CRHBP and Adrenal Gland
 Connective Tissue Antibodies  >1 publications with CRHBP and Connective Tissue
 Uterus Antibodies  >1 publications with CRHBP and Uterus
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