Rabbit Anti-CRTAP Polyclonal Antibody – Cat# MBS6288966

CRTAP Antibody (N-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the CRTAP antibody detected the CRTAP protein (arrow).

CRTAP Antibody – Rabbit Polyclonal

Name: CRTAP Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6288966
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6288966

The protein encoded by this gene is similar to the chicken and mouse CRTAP genes. The encoded protein is a scaffolding protein that may influence the activity of at least one member of the cytohesin/ARNO family in response to specific cellular stimuli.… More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CRTAP, Polyclonal Antibody

Full Product Name

CRTAP, NT (CRTAP, CASP, Cartilage-associated protein) (PE)

Product Gene Name

anti-CRTAP antibody

Product Synonym Names

CRTAP; CASP; Cartilage-associated protein

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

46,562 Da

OMIM

gene 610682

3D Structure

ModBase 3D Structure for O75718

Immunogen

CRTAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-59 amino acids from the N-terminal region of human CRTAP.

Conjugate

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-CRTAP antibody

Antibodies; Proteins

Applications Tested/Suitable for anti-CRTAP antibody

Western Blot (WB), FLISA

Application Notes for anti-CRTAP antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-CRTAP antibody

Morello, R., et al. Curr Osteoporos Rep 8(2):77-83(2010). Li, G.H., et al. Osteoporos Int 21(6):1009-1020(2010). Fratzl-Zelman, N., et al. Bone 46(3):820-826(2010). Chang, W., et al. Hum. Mol. Genet. 19(2):223-234(2010). Marini, J.C., et al. Cell Tissue Res. 339(1):59-70(2010).

Other Notes

Small volumes of anti-CRTAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CRTAP purchase

MBS6288966 is an antibody targeting CRTAP. Also known as CRTAP, NT (CRTAP, CASP, Cartilage-associated protein) (PE). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CRTAP. It may not necessarily be applicable to this product.

NCBI GI #

5453601

NCBI GeneID

10491

NCBI Accession #

NP_006362.1

UniProt Primary Accession #

O75718

UniProt Secondary Accession #

B2RBL6

UniProt Related Accession #

O75718

GenBank Nucleotide #

NM_006371.4

NCBI Official Full Name

cartilage-associated protein

NCBI Official Synonym Full Names

cartilage associated protein

NCBI Official Symbol

CRTAP

NCBI Official Synonym Symbols

OI7; CASP; P3H5; LEPREL3

UniProt Protein Name

Cartilage-associated protein

Protein Family

Cartilage-associated protein

UniProt Gene Name

CRTAP

UniProt Synonym Gene Names

CASP

UniProt Entry Name

CRTAP_HUMAN

NCBI Protein Information

cartilage-associated protein; leprecan-like 3; prolyl 3-hydroxylase family member 5 (non-enzymatic)

UniProt Comments for CRTAP

CRTAP: Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues. Defects in CRTAP are the cause of osteogenesis imperfecta type 7 (OI7). A connective tissue disorder characterized by short stature, short humeri and femora, coxa vara, white sclera, and the absence of dentinogenesis imperfecta. Multiple fractures are present at birth, and patients manifest moderate-severe bone fragility. Death may occurr in the perinatal period due to secondary respiratory insufficiency. Belongs to the leprecan family.

Protein type: Extracellular matrix; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 3p22.3

Cellular Component: proteinaceous extracellular matrix; extracellular space; endoplasmic reticulum lumen; endoplasmic reticulum

Molecular Function: protein complex binding

Biological Process: extracellular matrix organization and biogenesis; protein stabilization; spermatogenesis; peptidyl-proline hydroxylation to 3-hydroxy-L-proline

Disease: Osteogenesis Imperfecta, Type Vii

Research Articles on CRTAP

1. An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1.cartilage-associated protein.cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CRTAP antibody

Reference Product	PubMed Publications
LEPRE1 antibody	>38 publications with CRTAP and LEPRE1
PPIB antibody	>22 publications with CRTAP and PPIB
COL1A2 antibody	>20 publications with CRTAP and COL1A2
COL1A1 antibody	>18 publications with CRTAP and COL1A1
FKBP10 antibody	>11 publications with CRTAP and FKBP10
SERPINH1 antibody	>10 publications with CRTAP and SERPINH1

Pathways associated with anti-CRTAP antibody

Products by Pathway	Pathway Diagram
Collagen Biosynthesis And Modifying Enzymes Pathway antibodies	Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
Collagen Formation Pathway antibodies	Collagen Formation Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram

Diseases associated with anti-CRTAP antibody

Disease Name	Pubmed Publications
Osteogenesis Imperfecta Antibodies	>51 publications with CRTAP and Osteogenesis Imperfecta
Congenital Abnormalities Antibodies	>6 publications with CRTAP and Congenital Abnormalities
Osteogenesis imperfecta, type 7 Antibodies	>4 publications with CRTAP and Osteogenesis imperfecta, type 7
Disease Models, Animal Antibodies	>3 publications with CRTAP and Disease Models, Animal
Central Nervous System Diseases Antibodies	>1 publications with CRTAP and Central Nervous System Diseases
Brain Diseases Antibodies	>1 publications with CRTAP and Brain Diseases
Heart Defects, Congenital Antibodies	>1 publications with CRTAP and Heart Defects, Congenital
Kidney Diseases Antibodies	>1 publications with CRTAP and Kidney Diseases
Nervous System Diseases Antibodies	>1 publications with CRTAP and Nervous System Diseases
Necrosis Antibodies	>1 publications with CRTAP and Necrosis

Organs/Tissues associated with anti-CRTAP antibody

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>45 publications with CRTAP and Bone
Connective Tissue Antibodies	>15 publications with CRTAP and Connective Tissue
Skin Antibodies	>7 publications with CRTAP and Skin
Blood Antibodies	>2 publications with CRTAP and Blood
Eye Antibodies	>2 publications with CRTAP and Eye
Kidney Antibodies	>2 publications with CRTAP and Kidney
Lung Antibodies	>2 publications with CRTAP and Lung
Nerve Antibodies	>2 publications with CRTAP and Nerve
Bone Marrow Antibodies	>2 publications with CRTAP and Bone Marrow
Brain Antibodies	>2 publications with CRTAP and Brain