CSNK1D Antibody – Rabbit Polyclonal

This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

CK1D: an ubiquitous protein kinase of the CK1 family. Enriched at the centrosomes in interphase and at the spindle during mitosis. May play a role in cell cycle progression. Two splice variant isoforms have been described.

Protein type: EC 2.7.11.1; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.26; CK1 group; CK1 family

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: centrosome; cytosol; ER-Golgi intermediate compartment membrane; Golgi apparatus; Golgi membrane; neuron projection; nucleus; perinuclear region of cytoplasm; plasma membrane; spindle; spindle microtubule

Molecular Function: ATP binding; glycoprotein binding; peptide binding; phosphoprotein binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; tau-protein kinase activity

Biological Process: cellular protein metabolic process; circadian regulation of gene expression; COPII coating of Golgi vesicle; DNA repair; ER to Golgi vesicle-mediated transport; G2/M transition of mitotic cell cycle; Golgi organization and biogenesis; microtubule nucleation; mitotic cell cycle; organelle organization and biogenesis; peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein amino acid phosphorylation; post-translational protein modification; protein amino acid N-linked glycosylation via asparagine; protein amino acid phosphorylation; protein localization in Golgi apparatus; regulation of circadian rhythm; sensory cilium biogenesis; signal transduction; spindle assembly; Wnt receptor signaling pathway

Disease: Advanced Sleep Phase Syndrome, Familial, 2