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CTPS2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6289862

The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various… More details

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Product Overview

Online Datasheet in PDF
Product Name
CTPS2, Polyclonal Antibody
Full Product Name
CTPS2, CT (CTPS2, CTP synthase 2, CTP synthetase 2, UTP-ammonia ligase 2) (Azide free) (HRP)
Product Gene Name
anti-CTPS2 antibody
Product Synonym Names
CTPS2; CTP synthase 2; CTP synthetase 2; UTP--ammonia ligase 2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
65,678 Da
OMIM
300380
3D Structure
ModBase 3D Structure for Q9NRF8
Immunogen
CTPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 449-479 amino acids from the C-terminal region of human CTPS2.
Conjugate
HRP
Note
Preservative Free

Product Categories/Family for anti-CTPS2 antibody

Antibodies; Enzymes; Synthase
Applications Tested/Suitable for anti-CTPS2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CTPS2 antibody
WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CTPS2 antibody

CTPS2 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the CTPS2 antibody detected the CTPS2 protein (arrow).
Rabbit Anti-CTPS2 Polyclonal Antibody – Cat# MBS6289862

Western Blot (WB) of anti-CTPS2 antibody

Western blot analysis of CTPS2 (arrow) using rabbit polyclonal CTPS2 Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CTPS2 gene.
Rabbit Anti-CTPS2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6289862

Product References and Citations for anti-CTPS2 antibody

Kassel, K.M., et al. J. Biol. Chem. 285(44):33727-33736(2010). Olsen, J.V., et al. Cell 127(3):635-648(2006). Han, G.S., et al. J. Biol. Chem. 280(46):38328-38336(2005). Ross, M.T., et al. Nature 434(7031):325-337(2005). van Kuilenburg, A.B., et al. Biochim. Biophys. Acta 1492 (2-3), 548-552 (2000).

Other Notes

Small volumes of anti-CTPS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTPS2 purchase

MBS6289862 is an antibody targeting CTPS2. Also known as CTPS2, CT (CTPS2, CTP synthase 2, CTP synthetase 2, UTP-ammonia ligase 2) (Azide free) (HRP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CTPS2. It may not necessarily be applicable to this product.

NCBI GI #
28559085
NCBI GeneID
56474
NCBI Accession #
NP_787055.1
NCBI Related Accession #
NP_062831.3
UniProt Primary Accession #
Q9NRF8
UniProt Secondary Accession #
Q9BRI0; Q9H809; Q9H8K9; B3KWM2
UniProt Related Accession #
Q9NRF8
GenBank Nucleotide #
NM_175859.2
NCBI Official Full Name
CTP synthase 2
NCBI Official Synonym Full Names
CTP synthase 2
NCBI Official Symbol
CTPS2
UniProt Protein Name
CTP synthase 2
UniProt Synonym Protein Names
CTP synthetase 2; UTP--ammonia ligase 2
Protein Family
CTP synthase
UniProt Gene Name
CTPS2
UniProt Entry Name
PYRG2_HUMAN
NCBI Protein Information
CTP synthase 2; CTP synthase II; UTP-ammonia ligase 2; CTP synthetase type 2; cytidine 5'-triphosphate synthetase 2

NCBI Summary for CTPS2

The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
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UniProt Comments for CTPS2

CTPS2: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides. Belongs to the CTP synthase family.

Protein type: EC 6.3.4.2; Ligase; Nucleotide Metabolism - pyrimidine

Chromosomal Location of Human Ortholog: Xp22

Cellular Component: mitochondrion; cytosol

Molecular Function: CTP synthase activity; ATP binding

Biological Process: pyrimidine nucleotide metabolic process; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside and nucleotide interconversion; glutamine metabolic process
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Research Articles on CTPS2

1. CTPS2 was identified by genome-wide gene expression analyses as correlated with cellular sensitivity to cisplatin and carboplatin.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CTPS2 antibody

 Products by Pathway  Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Ribonucleotide Biosynthesis, UMP => UDP/UTP,CDP/CTP Pathway antibodies  Pyrimidine Ribonucleotide Biosynthesis, UMP => UDP/UTP,CDP/CTP Pathway Diagram
 Pyrimidine Ribonucleotide Biosynthesis, UMP => UDP/UTP,CDP/CTP Pathway antibodies  Pyrimidine Ribonucleotide Biosynthesis, UMP => UDP/UTP,CDP/CTP Pathway Diagram
 Synthesis And Interconversion Of Nucleotide Di- And Triphosphates Pathway antibodies  Synthesis And Interconversion Of Nucleotide Di- And Triphosphates Pathway Diagram
 UTP And CTP De Novo Biosynthesis Pathway antibodies  UTP And CTP De Novo Biosynthesis Pathway Diagram
 UTP And CTP Dephosphorylation I Pathway antibodies  UTP And CTP Dephosphorylation I Pathway Diagram

Diseases associated with anti-CTPS2 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >1 publications with CTPS2 and Disease Models, Animal
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