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CUX1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6290102

MBS6290102 is an antibody targeting CUX1. Also known as CUX1, CT (CUX1, CUTL1, Homeobox protein cut-like 1, CCAAT displacement protein, Homeobox protein cux-1) (Biotin). Reactive in Human. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CUX1, Polyclonal Antibody
Full Product Name
CUX1, CT (CUX1, CUTL1, Homeobox protein cut-like 1, CCAAT displacement protein, Homeobox protein cux-1) (Biotin)
Product Gene Name
anti-CUX1 antibody
Product Synonym Names
CUX1; CUTL1; Homeobox protein cut-like 1; CCAAT displacement protein; Homeobox protein cux-1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
77,455 Da
OMIM
116896
3D Structure
ModBase 3D Structure for P39880
Immunogen
CUX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1354-1382 amino acids from the C-terminal region of human CUX1.
Conjugate
Biotin
Note
Preservative Free

Product Categories/Family for anti-CUX1 antibody

Antibodies; Transcription Factors; Zinc; Ring; Homeobox
Applications Tested/Suitable for anti-CUX1 antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-CUX1 antibody
IHC: 1:50-100
ELISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CUX1 antibody

CUX1 Antibody (C-term) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the CUX1 antibody detected the CUX1 protein (arrow).
Rabbit Anti-CUX1 Polyclonal Antibody – Cat# MBS6290102

Immunohistochemistry (IHC) of anti-CUX1 antibody

CUX1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CUX1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-CUX1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6290102

Immunofluorescence (IF) of anti-CUX1 antibody

Fluorescent confocal image of Hela cell stained with CUX1 Antibody (C-term).Hela cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with CUX1 primary antibody (1:25, 1 h at 37 degree C). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37 degree C).Cytoplasmic actin was counterstained with Alexa Fluor 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37 degree C). Nuclei were counterstained with DAPI (blue) (10 ug/ml, 10 min). CUX1 immunoreactivity is localized to Nucleus significantly.
Rabbit Anti-CUX1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS6290102

Other Notes

Small volumes of anti-CUX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CUX1. It may not necessarily be applicable to this product.

NCBI GI #
148277064
NCBI GeneID
1523
NCBI Accession #
NP_853530.2
UniProt Primary Accession #
P39880
UniProt Secondary Accession #
Q6NYH4; Q75LE5; Q75MT2; Q75MT3; Q86UJ7; Q9UEV5; B3KV79; J3KQV9
UniProt Related Accession #
Q13948; P39880
GenBank Nucleotide #
NM_181552.3
NCBI Official Full Name
protein CASP isoform a
NCBI Official Synonym Full Names
cut like homeobox 1
NCBI Official Symbol
CUX1
NCBI Official Synonym Symbols
CDP; CUX; p75; CASP; CDP1; COY1; Clox; p100; p110; p200; CUTL1; GOLIM6; CDP/Cut; Cux/CDP; Nbla10317
UniProt Protein Name
Homeobox protein cut-like 1
UniProt Synonym Protein Names
CCAAT displacement protein; CDP; Homeobox protein cux-1
Protein Family
Homeobox protein
UniProt Gene Name
CUX1
UniProt Synonym Gene Names
CUTL1; CDP
UniProt Entry Name
CUX1_HUMAN
NCBI Protein Information
protein CASP

NCBI Summary for CUX1

The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011]
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UniProt Comments for CUX1

CUTL1: Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Belongs to the CUT homeobox family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: integral to Golgi membrane; nucleus; cytosol

Molecular Function: sequence-specific DNA binding; chromatin binding

Biological Process: regulation of transcription from RNA polymerase II promoter; intra-Golgi vesicle-mediated transport; transcription, DNA-dependent; multicellular organismal development; auditory receptor cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of dendrite morphogenesis; negative regulation of transcription from RNA polymerase II promoter; kidney development; lung development
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Research Articles on CUX1

1. Results show that Cux1 is expressed in cerebellar granule cell precursors and downregulated as they terminally differentiate; coexpression analysis in human medulloblastomas suggests another function related to DNA integrity and stability

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CUX1 antibody

 Reference Product  PubMed Publications
 WNT5A antibody  >3 publications with CUX1 and WNT5A
 TLE4 antibody  >2 publications with CUX1 and TLE4
 BCR antibody  >2 publications with CUX1 and BCR
 GOLGA5 antibody  >1 publications with CUX1 and GOLGA5
 ZMYM2 antibody  >1 publications with CUX1 and ZMYM2
 BANP antibody  >1 publications with CUX1 and BANP

Pathways associated with anti-CUX1 antibody

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Signal Transduction Pathway antibodies  Diseases Of Signal Transduction Pathway Diagram
 FGFR1 Mutant Receptor Activation Pathway antibodies  FGFR1 Mutant Receptor Activation Pathway Diagram
 Intra-Golgi And Retrograde Golgi-to-ER Traffic Pathway antibodies  Intra-Golgi And Retrograde Golgi-to-ER Traffic Pathway Diagram
 Intra-Golgi Traffic Pathway antibodies  Intra-Golgi Traffic Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Signaling By FGFR In Disease Pathway antibodies  Signaling By FGFR In Disease Pathway Diagram
 Signaling By FGFR1 In Disease Pathway antibodies  Signaling By FGFR1 In Disease Pathway Diagram
 Signaling By Cytosolic FGFR1 Fusion Mutants Pathway antibodies  Signaling By Cytosolic FGFR1 Fusion Mutants Pathway Diagram
 Vesicle-mediated Transport Pathway antibodies  Vesicle-mediated Transport Pathway Diagram

Diseases associated with anti-CUX1 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >12 publications with CUX1 and Breast Neoplasms
 Disease Models, Animal Antibodies  >11 publications with CUX1 and Disease Models, Animal
 Nervous System Diseases Antibodies  >10 publications with CUX1 and Nervous System Diseases
 Kidney Diseases Antibodies  >9 publications with CUX1 and Kidney Diseases
 Carcinogenesis Antibodies  >7 publications with CUX1 and Carcinogenesis
 Adenocarcinoma Antibodies  >5 publications with CUX1 and Adenocarcinoma
 Inflammation Antibodies  >5 publications with CUX1 and Inflammation
 Cardiovascular Diseases Antibodies  >4 publications with CUX1 and Cardiovascular Diseases
 Melanoma Antibodies  >4 publications with CUX1 and Melanoma
 Fibrosis Antibodies  >4 publications with CUX1 and Fibrosis

Organs/Tissues associated with anti-CUX1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >36 publications with CUX1 and Brain
 Blood Antibodies  >22 publications with CUX1 and Blood
 Nerve Antibodies  >12 publications with CUX1 and Nerve
 Kidney Antibodies  >11 publications with CUX1 and Kidney
 Embryonic Tissue Antibodies  >11 publications with CUX1 and Embryonic Tissue
 Lung Antibodies  >8 publications with CUX1 and Lung
 Liver Antibodies  >7 publications with CUX1 and Liver
 Bone Antibodies  >5 publications with CUX1 and Bone
 Heart Antibodies  >5 publications with CUX1 and Heart
 Muscle Antibodies  >4 publications with CUX1 and Muscle
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