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CXADR Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6290177

CXADR is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CXADR, Polyclonal Antibody
Full Product Name
CXADR, ID (CXADR, CAR, Coxsackievirus and adenovirus receptor, CVB3-binding protein, Coxsackievirus B-adenovirus receptor, HCVADR) (AP)
Product Gene Name
anti-CXADR antibody
Product Synonym Names
CXADR; CAR; Coxsackievirus and adenovirus receptor; CVB3-binding protein; Coxsackievirus B-adenovirus receptor; HCVADR
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase.
Purity/Purification
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
40,030 Da
Chromosome Location
Chromosome: 21; NC_000021.8 (18885224..18965897). Location: 21q21.1
OMIM
602621
3D Structure
ModBase 3D Structure for P78310
Immunogen
CXADR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140~169 amino acids from the Center region of human CXADR.
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-CXADR antibody

Antibodies; Infectious Disease Adenovirus
Applications Tested/Suitable for anti-CXADR antibody
Flow Cytometry (FC/FACS), ELISA (EIA), Western Blot (WB)
Application Notes for anti-CXADR antibody
FC/FACS: 1:10-50
ELISA: 1:1,000
WB: 1:50-100
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CXADR antibody

Western blot analysis of anti-CXADR Antibody (Center) in NCI-H460 cell line lysates (35ug/lane). CXADR(arrow) was detected using the purified Pab.
Rabbit Anti-CXADR Polyclonal Antibody – Cat# MBS6290177

Flow Cytometry (FC/FACS) of anti-CXADR antibody

Flow cytometric analysis of NCI-H460 cells using CXADR Antibody (Center) (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CXADR Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6290177

Product References and Citations for anti-CXADR antibody

Tomko R.P., Xu R., Philipson L.Proc. Natl. Acad. Sci. U.S.A. 94:3352-3356(1997). Bowles K.R., Gibson J., Hum. Genet. 105:354-359(1999). Fechner H., Haack A., Wang H., Wang X.Gene Ther. 6:1520-1535(1999). Martino T.A., Petric M., Weingartl H.Virology 271:99-108(2000). Ashbourne-Excoffon K.J.D., Hruska-Hageman A.M.J. Cell Sci. 117:4401-4409(2004).

Other Notes

Small volumes of anti-CXADR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CXADR purchase

MBS6290177 is an antibody targeting CXADR. Also known as CXADR, ID (CXADR, CAR, Coxsackievirus and adenovirus receptor, CVB3-binding protein, Coxsackievirus B-adenovirus receptor, HCVADR) (AP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CXADR. It may not necessarily be applicable to this product.

NCBI GI #
333470703
NCBI GeneID
1525
NCBI Accession #
NP_001193992.1
UniProt Primary Accession #
P78310
UniProt Secondary Accession #
O00694; Q8WWT6; Q8WWT7; Q8WWT8; Q9UKV4; B2R8V8
UniProt Related Accession #
P78310
GenBank Nucleotide #
NM_001207063.1
NCBI Official Full Name
coxsackievirus and adenovirus receptor isoform 2
NCBI Official Synonym Full Names
coxsackie virus and adenovirus receptor
NCBI Official Symbol
CXADR
NCBI Official Synonym Symbols
CAR; HCAR; CAR4/6
UniProt Protein Name
Coxsackievirus and adenovirus receptor
UniProt Synonym Protein Names
CVB3-binding protein; Coxsackievirus B-adenovirus receptor; HCVADR
Protein Family
Coxsackievirus and adenovirus receptor
UniProt Gene Name
CXADR
UniProt Synonym Gene Names
CAR; CAR; hCAR
UniProt Entry Name
CXAR_HUMAN
NCBI Protein Information
coxsackievirus and adenovirus receptor; HCVADR; CVB3-binding protein; coxsackievirus B-adenovirus receptor; 46 kD coxsackievirus and adenovirus receptor (CAR) protein

NCBI Summary for CXADR

The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011]
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UniProt Comments for CXADR

CXADR: a component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1 located in the plasma membrane of PMN.

Protein type: Membrane protein, integral; Receptor, misc.; Cell adhesion

Chromosomal Location of Human Ortholog: 21q21.1

Cellular Component: extracellular space; neuron projection; protein complex; tight junction; integral to plasma membrane; basolateral plasma membrane; apicolateral plasma membrane; acrosome; extracellular region; intercellular junction; lipid raft; nucleoplasm; adherens junction; growth cone; plasma membrane; neuromuscular junction; cell junction; filopodium

Molecular Function: viral receptor activity; integrin binding; identical protein binding; protein binding; beta-catenin binding; cell adhesion molecule binding; PDZ domain binding; receptor binding

Biological Process: mitochondrion organization and biogenesis; neutrophil chemotaxis; intercellular junction assembly and maintenance; entry of virus into host cell; regulation of immune response; heart development; gamma-delta T cell activation; heterophilic cell adhesion; cardiac muscle fiber development; actin cytoskeleton reorganization; germ cell migration; homotypic cell-cell adhesion; blood coagulation; defense response to virus; leukocyte migration
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Research Articles on CXADR

1. CAR expression in tumor tissues was significantly higher than that in normal lung tissues. CAR expression had a correlation with the histological grade of lung squamous cell carcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CXADR antibody

 Reference Product  PubMed Publications
 LNX1 antibody  >1 publications with CXADR and LNX1

Pathways associated with anti-CXADR antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Viral Myocarditis Pathway antibodies  Viral Myocarditis Pathway Diagram

Diseases associated with anti-CXADR antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >3 publications with CXADR and Heart Diseases
 Cardiovascular Diseases Antibodies  >3 publications with CXADR and Cardiovascular Diseases
 Edema Antibodies  >1 publications with CXADR and Edema
 Hypertension Antibodies  >1 publications with CXADR and Hypertension
 Neoplasms Antibodies  >1 publications with CXADR and Neoplasms
 Inflammation Antibodies  >1 publications with CXADR and Inflammation

Organs/Tissues associated with anti-CXADR antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >5 publications with CXADR and Heart
 Lung Antibodies  >3 publications with CXADR and Lung
 Brain Antibodies  >3 publications with CXADR and Brain
 Testis Antibodies  >2 publications with CXADR and Testis
 Vascular Antibodies  >1 publications with CXADR and Vascular
 Ear Antibodies  >1 publications with CXADR and Ear
 Kidney Antibodies  >1 publications with CXADR and Kidney
 Embryonic Tissue Antibodies  >1 publications with CXADR and Embryonic Tissue
 Stomach Antibodies  >1 publications with CXADR and Stomach
 Eye Antibodies  >1 publications with CXADR and Eye
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