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DAND4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6471862

MBS6471862 is an antibody targeting DAND4. Also known as DAND4, NT (Cerberus, Cerberus-related Protein, DAN Domain Family Member 4,CER1) (MaxLight 550). Reactive in Human. Host: Rabbit. More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DAND4, Polyclonal Antibody
Full Product Name
DAND4, NT (Cerberus, Cerberus-related Protein, DAN Domain Family Member 4,CER1) (MaxLight 550)
Product Gene Name
anti-DAND4 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Purity/Purification
Purified by Ammonium Sulfate Precipitation.
Specificity
Recognizes human CER1.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
30.084
OMIM
603777
3D Structure
ModBase 3D Structure for O95813
Immunogen
Synthetic peptide selected from the N-terminal region of human CER1 (KLH).
Conjugate
MaxLight550
Note
Preservative Free

Product Categories/Family for anti-DAND4 antibody

Antibodies; Proteins
Applications Tested/Suitable for anti-DAND4 antibody
Western Blot (WB), FLISA
Application Notes for anti-DAND4 antibody
WB: 1:50-1:100
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-DAND4 antibody

Western blot analysis of CER1 Antibody (N-term) in NCI-H460 cell line lysates (35ug/lane). CER1 (arrow) was detected using the purified Pab.
Rabbit Anti-DAND4 Polyclonal Antibody – Cat# MBS6471862

Immunohistochemistry (IHC) of anti-DAND4 antibody

(LEFT)Formalin-fixed and paraffin-embedded human lung carcinoma with CER1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. (RIGHT)Flow cytometric analysis of NCI-H292 cells using CER1 Antibody (N-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-DAND4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6471862

Product References and Citations for anti-DAND4 antibody

1. Tang, P.L., et.al., J. Bone Miner. Res. 24(6), 1013-1021 (2009). 2. Swinkels, M.E., et.al., Am. J. Med. Genet. A 146A(11), 1430-1438 (2008).

Other Notes

Small volumes of anti-DAND4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DAND4. It may not necessarily be applicable to this product.

NCBI GI #
4885135
NCBI GeneID
9350
NCBI Accession #
NP_005445
UniProt Primary Accession #
O95813
UniProt Related Accession #
O95813
GenBank Nucleotide #
NP_005445.1
NCBI Official Full Name
cerberus
NCBI Official Synonym Full Names
cerberus 1, DAN family BMP antagonist
NCBI Official Symbol
CER1
NCBI Official Synonym Symbols
DAND4
UniProt Protein Name
Cerberus
UniProt Synonym Protein Names
Cerberus-related protein; DAN domain family member 4
UniProt Gene Name
CER1
UniProt Synonym Gene Names
DAND4
UniProt Entry Name
CER1_HUMAN
NCBI Protein Information
cerberus

NCBI Summary for DAND4

This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008]
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UniProt Comments for DAND4

CER1: Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak. Belongs to the DAN family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 9p23-p22

Cellular Component: extracellular space; extracellular region

Molecular Function: morphogen activity; protein homodimerization activity; cytokine activity

Biological Process: BMP signaling pathway; anterior/posterior pattern formation; negative regulation of cell proliferation; nervous system development; negative regulation of activin receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; ureteric bud development; gastrulation; determination of dorsal identity; bone mineralization; cell migration involved in gastrulation; negative regulation of BMP signaling pathway; anterior/posterior axis specification
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Research Articles on DAND4

1. Cerberus binds and inhibits Nodal, Activin B, BMP-6, and BMP-7 but not BMP-2 or Activin A.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DAND4 antibody

 Reference Product  PubMed Publications
 NODAL antibody  >19 publications with DAND4 and NODAL
 BMP4 antibody  >13 publications with DAND4 and BMP4
 GREM2 antibody  >5 publications with DAND4 and GREM2
 BMP2 antibody  >3 publications with DAND4 and BMP2
 BMPR1A antibody  >2 publications with DAND4 and BMPR1A
 BMPR1B antibody  >1 publications with DAND4 and BMPR1B
 BMPR2 antibody  >1 publications with DAND4 and BMPR2

Pathways associated with anti-DAND4 antibody

 Products by Pathway  Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Endoderm Differentiation Pathway antibodies  Endoderm Differentiation Pathway Diagram
 Regulation Of Signaling By NODAL Pathway antibodies  Regulation Of Signaling By NODAL Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By BMP Pathway antibodies  Signaling By BMP Pathway Diagram
 Signaling By NODAL Pathway antibodies  Signaling By NODAL Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram

Diseases associated with anti-DAND4 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >3 publications with DAND4 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >3 publications with DAND4 and Neoplasms, Experimental
 Heart Defects, Congenital Antibodies  >2 publications with DAND4 and Heart Defects, Congenital
 Heart Diseases Antibodies  >2 publications with DAND4 and Heart Diseases
 Abnormalities, Multiple Antibodies  >2 publications with DAND4 and Abnormalities, Multiple
 Neurologic Manifestations Antibodies  >2 publications with DAND4 and Neurologic Manifestations
 Kidney Diseases Antibodies  >2 publications with DAND4 and Kidney Diseases
 Lung Diseases Antibodies  >1 publications with DAND4 and Lung Diseases
 Weight Loss Antibodies  >1 publications with DAND4 and Weight Loss
 Fatty Liver Antibodies  >1 publications with DAND4 and Fatty Liver

Organs/Tissues associated with anti-DAND4 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >21 publications with DAND4 and Embryonic Tissue
 Uncharacterized Tissue Antibodies  >1 publications with DAND4 and Uncharacterized Tissue
 Pancreas Antibodies  >1 publications with DAND4 and Pancreas
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