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DARC Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6290845

The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene… More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DARC, Polyclonal Antibody
Full Product Name
DARC, NT (DARC, FY, GPD, Duffy antigen/chemokine receptor, Fy glycoprotein, Glycoprotein D, Plasmodium vivax receptor, CD234) (MaxLight 650)
Product Gene Name
anti-DARC antibody
Product Synonym Names
DARC; FY; GPD; Duffy antigen/chemokine receptor; Fy glycoprotein; Glycoprotein D; Plasmodium vivax receptor; CD234
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human DARC.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
35,678 Da
OMIM
110700
3D Structure
ModBase 3D Structure for Q16570
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 1-30 in the N-terminal region of human DARC, UniProt Accession #NP_002027.2; Q16570.
Conjugate
MaxLight650
Note
Preservative Free

Product Categories/Family for anti-DARC antibody

Antibodies; CD Markers
Applications Tested/Suitable for anti-DARC antibody
Western Blot (WB), FLISA
Application Notes for anti-DARC antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-DARC antibody

Western blot analysis in CEM cell line lysates (35ug/lane) usingMBS641150. This demonstrates MBS641150 detected the DARC protein (arrow).
Rabbit Anti-DARC Polyclonal Antibody – Cat# MBS6290845

Product References and Citations for anti-DARC antibody

Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010). Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Le Goff, G.C., et al. Anal. Chem. 82(14):6185-6192(2010). Di Cristofaro, J., et al. J Mol Diagn 12(4):453-460(2010). Maestre, A., et al. PLoS ONE 5 (7), E11437 (2010).

Other Notes

Small volumes of anti-DARC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DARC purchase

MBS6290845 is an antibody targeting DARC. Also known as DARC, NT (DARC, FY, GPD, Duffy antigen/chemokine receptor, Fy glycoprotein, Glycoprotein D, Plasmodium vivax receptor, CD234) (MaxLight 650). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DARC. It may not necessarily be applicable to this product.

NCBI GI #
42822887
NCBI GeneID
2532
NCBI Accession #
NP_002027.2
UniProt Primary Accession #
Q16570
UniProt Secondary Accession #
O75898; Q16300; Q8WWE3; Q9UJP0; Q9UKZ5; Q9UKZ6; Q9UQE1; A8YPG5
UniProt Related Accession #
Q16570
GenBank Nucleotide #
NM_002036.3
NCBI Official Full Name
atypical chemokine receptor 1 isoform b
NCBI Official Synonym Full Names
atypical chemokine receptor 1 (Duffy blood group)
NCBI Official Symbol
ACKR1
NCBI Official Synonym Symbols
FY; Dfy; GPD; DARC; GpFy; CCBP1; CD234; WBCQ1
UniProt Protein Name
Duffy antigen/chemokine receptor
UniProt Synonym Protein Names
Fy glycoprotein; GpFy; Glycoprotein D; Plasmodium vivax receptor
Protein Family
Darcynin
UniProt Gene Name
DARC
UniProt Synonym Gene Names
FY; GPD; GpFy
UniProt Entry Name
DUFFY_HUMAN
NCBI Protein Information
atypical chemokine receptor 1; glycoprotein D; Fy glycoprotein; Duffy blood group antigen; plasmodium vivax receptor; Duffy blood group, chemokine receptor; Duffy blood group, atypical chemokine receptor

UniProt Comments for DARC

DARC: Non-specific receptor for many chemokines such as IL-8, GRO, RANTES, MCP-1 and TARC. It is also the receptor for the human malaria parasites Plasmodium vivax and Plasmodium knowlesi. Belongs to the G-protein coupled receptor Duffy family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, Duffy family; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1q21-q22

Cellular Component: recycling endosome; early endosome; integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; transmembrane receptor activity; C-C chemokine binding; receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; defense response; inflammatory response; regulation of chemokine production

Disease: White Blood Cell Count Quantitative Trait Locus 1; Blood Group, Duffy System; Malaria, Susceptibility To
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Research Articles on DARC

1. DARC facilitates CXCL1 inhibition of airway smooth muscle cell migration via modulation of the ERK-1/2 MAP kinase signaling pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-DARC antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Peptide GPCRs Pathway antibodies  Peptide GPCRs Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram

Diseases associated with anti-DARC antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >1 publications with DARC and Brain Diseases
 Inflammation Antibodies  >1 publications with DARC and Inflammation

Organs/Tissues associated with anti-DARC antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1 publications with DARC and Brain
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