Rabbit Anti-DBNL Polyclonal Antibody – Cat# MBS6290929

DBNL Antibody (C-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the DBNL antibody detected the DBNL protein (arrow).

DBNL Antibody – Rabbit Polyclonal

Name: DBNL Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6290929
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6290929

Actin-binding adapter protein. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Its association with dynamin suggests that it may also connect the actin cytoskeleton to endocytic function. Acts as a key component of the… More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DBNL, Polyclonal Antibody

Full Product Name

DBNL, CT (DBNL, CMAP, SH3P7, Drebrin-like protein, Cervical SH3P7, Cervical mucin-associated protein, Drebrin-F, HPK1-interacting protein of 55kD, SH3 domain-containing protein 7) (Azide free) (HRP)

Product Gene Name

anti-DBNL antibody

Product Synonym Names

DBNL; CMAP; SH3P7; Drebrin-like protein; Cervical SH3P7; Cervical mucin-associated protein; Drebrin-F; HPK1-interacting protein of 55kD; SH3 domain-containing protein 7

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

48,207 Da

Chromosome Location

Chromosome: 7; NC_000007.13 (44084239..44101315). Location: 7p13

OMIM

610106

3D Structure

ModBase 3D Structure for Q9UJU6

Immunogen

DBNL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 291-319 amino acids from the C-terminal region of human DBNL.

Conjugate

HRP

Note

Preservative Free

Product Categories/Family for anti-DBNL antibody

Antibodies; Mucin

Applications Tested/Suitable for anti-DBNL antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-DBNL antibody

WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-DBNL antibody

Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009). Haeckel, A., et al. J. Neurosci. 28(40):10031-10044(2008). Le Bras, S., et al. FEBS Lett. 581(5):967-974(2007). Lamesch, P., et al. Genomics 89(3):307-315(2007). Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007).

Other Notes

Small volumes of anti-DBNL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DBNL purchase

MBS6290929 is an antibody targeting DBNL. Also known as DBNL, CT (DBNL, CMAP, SH3P7, Drebrin-like protein, Cervical SH3P7, Cervical mucin-associated protein, Drebrin-F, HPK1-interacting protein of 55kD, SH3 domain-containing protein 7) (Azide free) (HRP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DBNL. It may not necessarily be applicable to this product.

NCBI GI #

62198235

NCBI GeneID

28988

NCBI Accession #

NP_001014436.1

NCBI Related Accession #

NP_001116428.1

UniProt Primary Accession #

Q9UJU6

UniProt Secondary Accession #

P84070; Q6IAI8; Q96F30; Q96K74; Q9HBN8; Q9NR72; A4D2I9

UniProt Related Accession #

Q9UJU6

GenBank Nucleotide #

NM_001014436.2

NCBI Official Full Name

drebrin-like protein isoform b

NCBI Official Synonym Full Names

drebrin-like

NCBI Official Symbol

DBNL

NCBI Official Synonym Symbols

ABP1; SH3P7; HIP-55

UniProt Protein Name

Drebrin-like protein

UniProt Synonym Protein Names

Cervical SH3P7; Cervical mucin-associated protein; Drebrin-F; HPK1-interacting protein of 55 kDa; HIP-55; SH3 domain-containing protein 7

Protein Family

Drebrin-like protein

UniProt Gene Name

DBNL

UniProt Synonym Gene Names

CMAP; SH3P7; HIP-55

UniProt Entry Name

DBNL_HUMAN

NCBI Protein Information

drebrin-like protein; drebrin-F; cervical SH3P7; SH3 domain-containing protein 7; cervical mucin-associated protein; HPK1-interacting protein of 55 kDa; src homology 3 domain-containing protein HIP-55

UniProt Comments for DBNL

DBNL: an SH3-containing adaptor protein. Interacts with hematopoietic progenitor kinase 1a (HIPK1). It is recruited to glycolipid-enriched microdomains following T cell receptor (TCR) stimulation. Interacts with and is phosphorylated by ZAP-70 after TCR signaling. May regulate JNK activation following TCR signaling, presumably via its interaction with HIPKIt is a member of the drebrin family of proteins that are developmentally regulated in the brain.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7p13

Cellular Component: Golgi membrane; ruffle; lamellipodium; dendrite; postsynaptic density; cytoplasm; plasma membrane; clathrin coated vesicle membrane; podosome; cell cortex; cytosol; cell junction

Molecular Function: actin filament binding; protein C-terminus binding; protein domain specific binding; protein binding; enzyme activator activity; actin binding

Biological Process: receptor-mediated endocytosis; synaptogenesis; immune system process; apoptosis; Rac protein signal transduction; neurite morphogenesis; activation of JNK activity; cell structure disassembly during apoptosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DBNL antibody

Reference Product	PubMed Publications
SYK antibody	>3 publications with DBNL and SYK

Pathways associated with anti-DBNL antibody

Products by Pathway	Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptotic Cleavage Of Cellular Proteins Pathway antibodies	Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
Apoptotic Execution Phase Pathway antibodies	Apoptotic Execution Phase Pathway Diagram
Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway antibodies	Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway Diagram
JNK Signaling In The CD4+ TCR Pathway antibodies	JNK Signaling In The CD4+ TCR Pathway Diagram
T Cell Receptor Signaling Pathway antibodies	T Cell Receptor Signaling Pathway Diagram
TCR Signaling In Naive CD4+ T Cells Pathway antibodies	TCR Signaling In Naive CD4+ T Cells Pathway Diagram

Diseases associated with anti-DBNL antibody

Disease Name	Pubmed Publications
Necrosis Antibodies	>1 publications with DBNL and Necrosis
Status Epilepticus Antibodies	>1 publications with DBNL and Status Epilepticus
Cardiovascular Diseases Antibodies	>1 publications with DBNL and Cardiovascular Diseases
Disease Models, Animal Antibodies	>1 publications with DBNL and Disease Models, Animal
Inflammation Antibodies	>1 publications with DBNL and Inflammation

Organs/Tissues associated with anti-DBNL antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>8 publications with DBNL and Brain
Muscle Antibodies	>3 publications with DBNL and Muscle
Blood Antibodies	>3 publications with DBNL and Blood
Spleen Antibodies	>2 publications with DBNL and Spleen
Heart Antibodies	>1 publications with DBNL and Heart
Embryonic Tissue Antibodies	>1 publications with DBNL and Embryonic Tissue
Thymus Antibodies	>1 publications with DBNL and Thymus
Lung Antibodies	>1 publications with DBNL and Lung