DDX23 Antibody – Rabbit Polyclonal

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]

DDX23: Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.

Protein type: Helicase; RNA-binding; RNA processing; RNA splicing; EC 3.6.4.13; Spliceosome

Chromosomal Location of Human Ortholog: 12q13.12

Cellular Component: nucleoplasm; mitochondrion; snRNP U5; nucleolus; plasma membrane; nucleus

Molecular Function: protein binding; ATP-dependent helicase activity; ATP binding; ATP-dependent RNA helicase activity

Biological Process: nuclear mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; cis assembly of pre-catalytic spliceosome; RNA splicing; gene expression