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DEK Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3907609

DEK is a chromatin-binding protein that may serve as an architectural protein at promoter or enhancer sites of particular genes and may be involved in the regulation of transcription and mRNA processing. DEK has been identified as an oncoprotein and an… More details

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Product Overview

Online Datasheet in PDF
Product Name
DEK, Polyclonal Antibody
Full Product Name
Rabbit anti-DEK IHC Antibody, Affinity Purified
Product Gene Name
anti-DEK antibody
Product Synonym Names
DEK oncogene (DNA binding); protein DEK; D6S231E; Protein DEK; DEK proto-oncogene
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Whole IgG. Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
250ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
38,705 Da
OMIM
125264
3D Structure
ModBase 3D Structure for P35659
Predicted Reactivity
Monkey, Gorilla, Chimpanzee, Crab-eating macaque
Immunogen
Between 250 and 300
Conjugation
Unconjugated

Product Categories/Family for anti-DEK antibody

Primary Antibodies
Applications Tested/Suitable for anti-DEK antibody
Immunohistochemistry (IHC)
Application Notes for anti-DEK antibody
IHC: 1:100-1:500

Immunohistochemistry (IHC) of anti-DEK antibody

Detection of human DEK by immunohistochemistry. Sample: FFPE section of human stomach carcinoma. Antibody: Affinity purified rabbit anti-DEK (Cat. No. MBS3907609) used at a dilution of 1:250. Detection: DAB
Rabbit Anti-DEK Polyclonal Antibody – Cat# MBS3907609

Immunohistochemistry (IHC) of anti-DEK antibody

Detection of human DEK by immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-DEK (Cat. No. MBS3907609) used at a dilution of 1:250. Detection: DAB
Rabbit Anti-DEK Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS3907609

Other Notes

Small volumes of anti-DEK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DEK purchase

MBS3907609 is an antibody targeting DEK. Also known as Rabbit anti-DEK IHC Antibody, Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DEK. It may not necessarily be applicable to this product.

NCBI GI #
4503249
NCBI GeneID
7913
NCBI Accession #
NP_003463.1
UniProt Primary Accession #
P35659
UniProt Secondary Accession #
Q5TGV4; Q5TGV5; B2R6K6; B4DN37
UniProt Related Accession #
P35659
GenBank Nucleotide #
NM_003472.4
NCBI Official Full Name
protein DEK isoform 1
NCBI Official Synonym Full Names
DEK proto-oncogene
NCBI Official Symbol
DEK
NCBI Official Synonym Symbols
D6S231E
UniProt Protein Name
Protein DEK
Protein Family
Protein
UniProt Gene Name
DEK
UniProt Entry Name
DEK_HUMAN
NCBI Protein Information
protein DEK

NCBI Summary for DEK

This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
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UniProt Comments for DEK

DEK: a ubiquitous protein with a SAP domain, which is found in a variety of nuclear proteins involved in transcription, DNA repair, RNA processing or apoptotic chromatin degradation. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA and is also involved in splice site selection during mRNA processing. A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemias (AML).

Protein type: Histone-binding; Oncoprotein; DNA-binding; DNA replication; RNA splicing

Chromosomal Location of Human Ortholog: 6p22.3

Cellular Component: contractile fiber; nucleoplasm; nucleus

Molecular Function: DNA binding; histone binding

Biological Process: chromatin modification; positive regulation of gene expression, epigenetic; regulation of transcription from RNA polymerase II promoter; signal transduction; transcription from RNA polymerase II promoter; viral genome replication
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Research Articles on DEK

1. These findings define DEK as an important and multifunctional mediator of homologous recombination.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-DEK antibody

 Products by Pathway  Pathway Diagram
 B-WICH Complex Positively Regulates RRNA Expression Pathway antibodies  B-WICH Complex Positively Regulates RRNA Expression Pathway Diagram
 Epigenetic Regulation Of Gene Expression Pathway antibodies  Epigenetic Regulation Of Gene Expression Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Positive Epigenetic Regulation Of RRNA Expression Pathway antibodies  Positive Epigenetic Regulation Of RRNA Expression Pathway Diagram
 Transcriptional Regulation By The AP-2 (TFAP2) Family Of Transcription Factors Pathway antibodies  Transcriptional Regulation By The AP-2 (TFAP2) Family Of Transcription Factors Pathway Diagram
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