Rabbit Anti-DGKH Polyclonal Antibody – Cat# MBS9444830

DGKH Antibody – Rabbit Polyclonal

Name: DGKH Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS9444830
Price: 435 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9444830

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes… More details

$435 / 0.1 mL (Biotin) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DGKH, Polyclonal Antibody

Full Product Name

DGKH Conjugated Antibody

Product Gene Name

anti-DGKH antibody

Product Synonym Names

iacylglycerol kinase eta; EC 2.7.1.107; Diglyceride kinase eta; DGK-eta; DAG kinase eta

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

Specificity

The antibody detects endogenous levels of total DGKH protein

Preparation and Storage

Store at 4 degree C for 6 months.

Molecular Weight

134,866 Da

Chromosome Location

Chromosome: 13; NC_000013.10 (42614172..42803891). Location: 13q14.11

OMIM

604071

3D Structure

ModBase 3D Structure for Q86XP1

Immunogen

Synthesized peptide derived from internal of human DGKH.

Conjugation

Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750

Excitation Emission

AF350: 346nm/442nm

Applications Tested/Suitable for anti-DGKH antibody

Most Applications

Application Notes for anti-DGKH antibody

Suggested Dilution:
AF350 conjugated: most applications: 1:50-1:250
AF405 conjugated: most applications: 1:50-1:250
AF488 conjugated: most applications: 1:50-1:250
AF555 conjugated: most applications: 1:50-1:250
AF594 conjugated: most applications: 1:50-1:250
AF647 conjugated: most applications: 1:50-1:250
AF680 conjugated: most applications: 1:50-1:250
AF750 conjugated: most applications: 1:50-1:250
Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000

Other Notes

Small volumes of anti-DGKH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DGKH purchase

MBS9444830 is an antibody targeting DGKH. Also known as DGKH Conjugated Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DGKH. It may not necessarily be applicable to this product.

NCBI GI #

325197213

NCBI GeneID

160851

NCBI Accession #

NP_001191433.1

UniProt Primary Accession #

Q86XP1

UniProt Secondary Accession #

Q5VZW0; Q6PI56; Q86XP2; Q8N3N0; Q8N7J9; A2A2W7; A6NFX7; B4DZ34

UniProt Related Accession #

Q86XP1

GenBank Nucleotide #

NM_001204504.1

NCBI Official Full Name

diacylglycerol kinase eta isoform 1

NCBI Official Synonym Full Names

diacylglycerol kinase, eta

NCBI Official Symbol

DGKH

NCBI Official Synonym Symbols

DGKeta

UniProt Protein Name

Diacylglycerol kinase eta

UniProt Synonym Protein Names

Diglyceride kinase eta

UniProt Gene Name

DGKH

UniProt Synonym Gene Names

DAG kinase eta; DGK-eta

UniProt Entry Name

DGKH_HUMAN

NCBI Protein Information

diacylglycerol kinase eta; DGK-eta; DAG kinase eta; diglyceride kinase eta

NCBI Summary for DGKH

This gene encodes a member of the diacylglycerol kinase (DGK) enzyme family of proteins, specifically the type II DGK subfamily. Members of this family are involved in regulating the intracellular concentrations of diacylglycerol and phosphatidic acid. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2011]

UniProt Comments for DGKH

DGKH: Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization. Belongs to the eukaryotic diacylglycerol kinase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - glycerolipid; Motility/polarity/chemotaxis; Kinase, other; EC 2.7.1.107; Lipid Metabolism - glycerophospholipid

Chromosomal Location of Human Ortholog: 13q14.11

Cellular Component: nuclear membrane; cytoplasm; plasma membrane; nucleus; endosome

Molecular Function: metal ion binding; diacylglycerol kinase activity; ATP binding; NAD+ kinase activity

Biological Process: platelet activation; protein kinase C activation; blood coagulation; phosphorylation; protein oligomerization

Research Articles on DGKH

1. DGKK variants are associated with hypospadias

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-DGKH antibody

Products by Pathway	Pathway Diagram
Effects Of PIP2 Hydrolysis Pathway antibodies	Effects Of PIP2 Hydrolysis Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies	Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
Glycerolipid Metabolism Pathway antibodies	Glycerolipid Metabolism Pathway Diagram
Glycerolipid Metabolism Pathway antibodies	Glycerolipid Metabolism Pathway Diagram
Glycerophospholipid Metabolism Pathway antibodies	Glycerophospholipid Metabolism Pathway Diagram
Glycerophospholipid Metabolism Pathway antibodies	Glycerophospholipid Metabolism Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Phosphatidylinositol Signaling System Pathway antibodies	Phosphatidylinositol Signaling System Pathway Diagram

Diseases associated with anti-DGKH antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>2 publications with DGKH and Neoplasms
Depressive Disorder Antibodies	>2 publications with DGKH and Depressive Disorder
Disease Models, Animal Antibodies	>2 publications with DGKH and Disease Models, Animal
Diabetes Mellitus Antibodies	>1 publications with DGKH and Diabetes Mellitus
Hyperplasia Antibodies	>1 publications with DGKH and Hyperplasia
Anxiety Disorders Antibodies	>1 publications with DGKH and Anxiety Disorders
Kidney Diseases Antibodies	>1 publications with DGKH and Kidney Diseases
Precancerous Conditions Antibodies	>1 publications with DGKH and Precancerous Conditions

Organs/Tissues associated with anti-DGKH antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>3 publications with DGKH and Brain