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DIDO1 Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6000253

Apoptosis plays an important role in many cellular processes. Dio-1 (Death Inducer-O bliterator-1), a putative transcription factor, has been indicated to function in the onset of apoptosis. Dio-1 expression is upregulated when an apoptosis is detected. It… More details

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Product Overview

Online Datasheet in PDF
Product Name
DIO-1 (DIDO1), Polyclonal Antibody
Full Product Name
DIO-1 (Death-inducer Obliterator 1, hDido1, Death-associated Transcription Factor 1, DATF-1, DIDO1, C20orf158, DATF1, KIAA0333)
Product Gene Name
anti-DIDO1 antibody
Product Synonym Names
Anti -DIO-1 (Death-inducer Obliterator 1, hDido1, Death-associated Transcription Factor 1, DATF-1, DIDO1, C20orf158, DATF1, KIAA0333)
Immunogen Sequence
MDDKGDPSNE EAPKAIKPTS KEFRKTWGFR RTTIAKREGA GDAEADPLEP PPPQQQLGLS LRRSGRQPKR TERVEQFLTI ARRRGRRSMP VSLEDSGEPT SCPATDAETA SEGSVESASE TRSGPQSAST AVKERPASSE KVKGGDDHDD TSDSDSDGLT LKELQNRLRR KREQEPTERP LKGIQSRLRK KRREEGPAET VGSEASDTVE GVLPSKQEPE NDQGVVSQAG KDDRESKLEG KAAQDIKDEE PGDLGRPKPE CEGYDPNALY CICRQPHNNR FMICCDRCEE WFHGDCVGIS EARGRLLERN GEDYICPNCT ILQVQDETHS ETADQQEAKW RPGDADGTDC TSIGTIEQKS SEDQGIKGRI EKAANPSGKK KLKIFQPVIE APGASKCIGP GCCHVAQPDS VYCSNDCILK HAAATMKFLS SGKEQKPKPK EKMKMKPEKP SLPKCGAQAG IKISSVHKRP APEKKETTVK KAVVVPARSE ALGKEAACES STPSWASDHN YNAVKPEKTA APSPSLLYKC SGKYLYSLHP SLIA
Clonality
Polyclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human DIDO1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
243,873 Da
Chromosome Location
Chromosome: 20; NC_000020.10 (61509090..61569304, complement). Location: 20q13.33
OMIM
604140
3D Structure
ModBase 3D Structure for Q9BTC0
Immunogen
Full length human DIDO1, aa1-544 (AAH00770.1).

Product Categories/Family for anti-DIDO1 antibody

Antibodies; Abs to Transcription Factors
Applications Tested/Suitable for anti-DIDO1 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-DIDO1 antibody
Suitable for use in Immunofluorescence and Western Blot.
Dilution: Immunofluorescence: 10ug/ml

Western Blot (WB) of anti-DIDO1 antibody

Western Blot analysis of DIDO1 expression in transfected 293T cell line by DIDO1 polyclonal antibody. Lane 1: DIDO1 transfected lysate (59.84kD). Lane 2: Non-transfected lysate.
Mouse Anti-DIDO1 Polyclonal Antibody – Cat# MBS6000253

Immunofluorescence (IF) of anti-DIDO1 antibody

Immunofluorescence of purified antibody to DIDO1 on HeLa cell. [antibody concentration 10ug/ml].
Mouse Anti-DIDO1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS6000253

Other Notes

Small volumes of anti-DIDO1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DIDO1 purchase

MBS6000253 is an antibody targeting DIDO1. Also known as DIO-1 (Death-inducer Obliterator 1, hDido1, Death-associated Transcription Factor 1, DATF-1, DIDO1, C20orf158, DATF1, KIAA0333). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for DIDO1. It may not necessarily be applicable to this product.

NCBI GI #
301129170
NCBI GeneID
11083
NCBI Accession #
NP_001180298.1
UniProt Primary Accession #
Q9BTC0
UniProt Secondary Accession #
O15043; Q3ZTL7; Q3ZTL8; Q4VXS1; Q4VXS2; Q4VXV8; Q4VXV9; Q96D72; A8MY65; B9EH82; E1P5I1
UniProt Related Accession #
Q9BTC0
GenBank Nucleotide #
NM_001193369.1
NCBI Official Full Name
death-inducer obliterator 1 isoform c
NCBI Official Synonym Full Names
death inducer-obliterator 1
NCBI Official Symbol
DIDO1
NCBI Official Synonym Symbols
BYE1; DIO1; DATF1; DIDO2; DIDO3; DIO-1; DATF-1; C20orf158; dJ885L7.8
UniProt Protein Name
Death-inducer obliterator 1
UniProt Synonym Protein Names
Death-associated transcription factor 1
Protein Family
Death-inducer obliterator
UniProt Gene Name
DIDO1
UniProt Synonym Gene Names
C20orf158; DATF1; KIAA0333; DIO-1; hDido1; DATF-1
UniProt Entry Name
DIDO1_HUMAN
NCBI Protein Information
death-inducer obliterator 1; death-associated transcription factor 1

NCBI Summary for DIDO1

Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008]
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UniProt Comments for DIDO1

DATF1: Putative transcription factor, weakly pro-apoptotic when overexpressed. Tumor suppressor. Ubiquitous. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: cytoplasm; spindle; nucleus

Molecular Function: zinc ion binding

Biological Process: transcription, DNA-dependent
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Research Articles on DIDO1

1. Dido1 induces the expression of Integrin alphaV, thereby promoting the attachment, migration, invasion and apoptosis resistance of melanoma cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-DIDO1 antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 Meiosis Pathway antibodies  Meiosis Pathway Diagram
 Meiotic Synapsis Pathway antibodies  Meiotic Synapsis Pathway Diagram

Diseases associated with anti-DIDO1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >5 publications with DIDO1 and Neoplasms
 Intestinal Neoplasms Antibodies  >2 publications with DIDO1 and Intestinal Neoplasms
 Adenoma Antibodies  >2 publications with DIDO1 and Adenoma
 Memory Disorders Antibodies  >1 publications with DIDO1 and Memory Disorders
 Adenocarcinoma Antibodies  >1 publications with DIDO1 and Adenocarcinoma
 Breast Neoplasms Antibodies  >1 publications with DIDO1 and Breast Neoplasms
 Necrosis Antibodies  >1 publications with DIDO1 and Necrosis
 Learning Disorders Antibodies  >1 publications with DIDO1 and Learning Disorders

Organs/Tissues associated with anti-DIDO1 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >3 publications with DIDO1 and Bone
 Bone Marrow Antibodies  >2 publications with DIDO1 and Bone Marrow
 Thyroid Antibodies  >2 publications with DIDO1 and Thyroid
 Liver Antibodies  >2 publications with DIDO1 and Liver
 Prostate Antibodies  >1 publications with DIDO1 and Prostate
 Blood Antibodies  >1 publications with DIDO1 and Blood
 Skin Antibodies  >1 publications with DIDO1 and Skin
 Spleen Antibodies  >1 publications with DIDO1 and Spleen
 Brain Antibodies  >1 publications with DIDO1 and Brain
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