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DIRC2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6292212

This gene encodes a membrane-bound protein from the major facilitator superfamily of transporters. Disruption of this gene by translocation has been associated with haplo-insufficiency and renal cell carcinomas. Alternatively spliced transcript variants have… More details

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Product Overview

Online Datasheet in PDF
Product Name
DIRC2, Polyclonal Antibody
Full Product Name
DIRC2, ID (DIRC2, Disrupted in renal carcinoma protein 2, Disrupted in renal cancer protein 2) (AP)
Product Gene Name
Product Synonym Names
DIRC2; Disrupted in renal carcinoma protein 2; Disrupted in renal cancer protein 2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
52,088 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (122513901..122599986). Location: 3q21.1
OMIM
602773
3D Structure
ModBase 3D Structure for Q96SL1
Immunogen
DIRC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 202-229 amino acids from the Central region of human DIRC2.
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-DIRC2 antibody

Applications Tested/Suitable for anti-DIRC2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-DIRC2 antibody
WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-DIRC2 antibody

DIRC2 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the DIRC2 antibody detected the DIRC2 protein (arrow).
Rabbit Anti-DIRC2 Polyclonal Antibody – Cat# MBS6292212

Product References and Citations for anti-DIRC2 antibody

Bodmer, D., et al. Cancer Genet. Cytogenet. 136(2):95-100(2002). Bodmer, D., et al. Hum. Mol. Genet. 11(6):641-649(2002).

Other Notes

Small volumes of anti-DIRC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DIRC2 purchase

MBS6292212 is an antibody targeting DIRC2. Also known as DIRC2, ID (DIRC2, Disrupted in renal carcinoma protein 2, Disrupted in renal cancer protein 2) (AP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DIRC2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
disrupted in renal carcinoma protein 2
NCBI Official Synonym Full Names
disrupted in renal carcinoma 2
NCBI Official Symbol
DIRC2
NCBI Official Synonym Symbols
RCC4
UniProt Protein Name
Disrupted in renal carcinoma protein 2
UniProt Synonym Protein Names
Disrupted in renal cancer protein 2
UniProt Gene Name
DIRC2
UniProt Entry Name
DIRC2_HUMAN
NCBI Protein Information
disrupted in renal carcinoma protein 2; renal cell carcinoma 4; disrupted in renal cancer protein 2

UniProt Comments for DIRC2

DIRC2: Electrogenic metabolite transporter. A chromosomal aberration involving DIRC2 has been found in a family with renal carcinoma. Translocation t(2;3)(q35;q21). Belongs to the major facilitator superfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3q21.1

Cellular Component: lysosomal membrane; integral to membrane

Biological Process: transport

Disease: Renal Cell Carcinoma, Nonpapillary
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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