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DLG7 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6292314

DLG7 is potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. DLG7 is mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. DLG7 is key regulator of adherens junction integrity and differentiation that may be… More details

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Product Overview

Online Datasheet in PDF
Product Name
DLG7, Polyclonal Antibody
Full Product Name
DLG7, ID (DLGAP5, DLG7, KIAA0008, Disks large-associated protein 5, Discs large homolog 7, Disks large-associated protein DLG7, Hepatoma up-regulated protein) (FITC)
Product Gene Name
anti-DLG7 antibody
Product Synonym Gene Name
DLGAP5
Product Synonym Names
DLGAP5; DLG7; KIAA0008; Disks large-associated protein 5; Discs large homolog 7; Disks large-associated protein DLG7; Hepatoma up-regulated protein
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
Purity/Purification
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer.
Molecular Weight
846
3D Structure
ModBase 3D Structure for Q15398
Immunogen
DLG7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-265 amino acids from the Central region of human DLG7.
Conjugate
FITC
Note
Preservative Free

Product Categories/Family for anti-DLG7 antibody

Antibodies; KIAA; orf
Applications Tested/Suitable for anti-DLG7 antibody
Flow Cytometry (FC/FACS), ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-DLG7 antibody
FC/FACS: 1:10-50
ELISA: 1:1,000
IHC: 1:50-100
WB: 1:50-100
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-DLG7 antibody

Western blot analysis of DLG7 Antibody (Center) in 293 cell line lysates (35ug/lane).DLG7 (arrow) was detected using the purified Pab.
Rabbit Anti-DLG7 Polyclonal Antibody – Cat# MBS6292314

Immunohistochemistry (IHC) of anti-DLG7 antibody

DLG7 Antibody (Center) IHC analysis in formalin fixed and paraffin embedded hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the DLG7 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-DLG7 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6292314

Flow Cytometry (FC/FACS) of anti-DLG7 antibody

DLG7 Antibody (Center) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-DLG7 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6292314

Product References and Citations for anti-DLG7 antibody

de Reynies, A., et al. J. Clin. Oncol. 27(7):1108-1115(2009). Wong, J., et al. Mol. Biol. Cell 19(5):2083-2091(2008). Gudmundsson, K.O., et al. Stem Cells 25(6):1498-1506(2007).

Other Notes

Small volumes of anti-DLG7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DLG7 purchase

MBS6292314 is an antibody targeting DLG7. Also known as DLG7, ID (DLGAP5, DLG7, KIAA0008, Disks large-associated protein 5, Discs large homolog 7, Disks large-associated protein DLG7, Hepatoma up-regulated protein) (FITC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DLG7. It may not necessarily be applicable to this product.

NCBI GI #
82592583
NCBI GeneID
9787
NCBI Accession #
Q15398.2
UniProt Primary Accession #
Q15398
UniProt Secondary Accession #
Q86T11; Q8NG58; A8MTM6; B4DRM8
UniProt Related Accession #
Q15398
NCBI Official Full Name
Disks large-associated protein 5
NCBI Official Synonym Full Names
discs, large (Drosophila) homolog-associated protein 5
NCBI Official Symbol
DLGAP5
NCBI Official Synonym Symbols
DLG7; HURP
UniProt Protein Name
Disks large-associated protein 5
UniProt Synonym Protein Names
Discs large homolog 7; Disks large-associated protein DLG7; Hepatoma up-regulated protein; HURP
Protein Family
Disks large-associated protein
UniProt Gene Name
DLGAP5
UniProt Synonym Gene Names
DLG7; KIAA0008; DAP-5; HURP
UniProt Entry Name
DLGP5_HUMAN
NCBI Protein Information
disks large-associated protein 5; DAP-5; discs large homolog 7; discs, large homolog 7; hepatoma up-regulated protein; disks large-associated protein DLG7

UniProt Comments for DLG7

DLG7: a cell cycle regulator that may play a role in carcinogenesis. Elevated levels of expression detected in the G2/M phase of synchronized cultures of HeLa cells. Required for chromosome congression and alignment. Stabilizes mitotic microtubules, promotes microtubule polymerization and controls spindle formation and dynamics Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Interacts with CDC2 and localizes to the spindle poles in mitotic cells. Interacts with the C-terminal proline-rich region of FBXO7. Recruited by FBXO7 to a SCF (SKP1-CUL1-F-box) protein complex in a CDC2/Cyclin B-phosphorylation dependent manner. Colocalizes with E-cadherin (CDH1) at sites of cell-cell contact in intestinal epithelial cells. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. Two alternatively spliced isoforms have been described.

Protein type: Cell cycle regulation; Microtubule-binding

Chromosomal Location of Human Ortholog: 14q22.3

Cellular Component: cytoplasm; microtubule organizing center; spindle pole centrosome; nucleus

Molecular Function: protein binding; phosphoprotein phosphatase activity

Biological Process: cell proliferation; dephosphorylation; cell-cell signaling; positive regulation of mitotic metaphase/anaphase transition; mitotic chromosome movement towards spindle pole
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Research Articles on DLG7

1. Detection of urinary HURP RNA is a useful for early detection of bladder cancer and bilharzial bladder cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DLG7 antibody

 Reference Product  PubMed Publications
 CCNB1 antibody  >3 publications with DLG7 and CCNB1
 TTK antibody  >2 publications with DLG7 and TTK
 NUSAP1 antibody  >2 publications with DLG7 and NUSAP1
 CDK1 antibody  >2 publications with DLG7 and CDK1
 TPX2 antibody  >2 publications with DLG7 and TPX2
 AURKA antibody  >2 publications with DLG7 and AURKA
 CDCA8 antibody  >1 publications with DLG7 and CDCA8
 KIF23 antibody  >1 publications with DLG7 and KIF23
 NDC80 antibody  >1 publications with DLG7 and NDC80
 KIF11 antibody  >1 publications with DLG7 and KIF11

Pathways associated with anti-DLG7 antibody

 Products by Pathway  Pathway Diagram
 Aurora A Signaling Pathway antibodies  Aurora A Signaling Pathway Diagram

Diseases associated with anti-DLG7 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >11 publications with DLG7 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >11 publications with DLG7 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >9 publications with DLG7 and Liver Diseases
 Liver Neoplasms Antibodies  >9 publications with DLG7 and Liver Neoplasms
 Cell Transformation, Neoplastic Antibodies  >3 publications with DLG7 and Cell Transformation, Neoplastic
 Lung Neoplasms Antibodies  >2 publications with DLG7 and Lung Neoplasms
 Prostatic Neoplasms Antibodies  >2 publications with DLG7 and Prostatic Neoplasms
 Breast Neoplasms Antibodies  >2 publications with DLG7 and Breast Neoplasms
 Carcinoma, Squamous Cell Antibodies  >2 publications with DLG7 and Carcinoma, Squamous Cell
 Ovarian Neoplasms Antibodies  >1 publications with DLG7 and Ovarian Neoplasms

Organs/Tissues associated with anti-DLG7 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >8 publications with DLG7 and Liver
 Bladder Antibodies  >4 publications with DLG7 and Bladder
 Blood Antibodies  >3 publications with DLG7 and Blood
 Lung Antibodies  >2 publications with DLG7 and Lung
 Bone Antibodies  >2 publications with DLG7 and Bone
 Bone Marrow Antibodies  >2 publications with DLG7 and Bone Marrow
 Intestine Antibodies  >1 publications with DLG7 and Intestine
 Embryonic Tissue Antibodies  >1 publications with DLG7 and Embryonic Tissue
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