DNAH2 Antibody – Rabbit Polyclonal

Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly

By similarity.

Subunit structure: Consists of at least two heavy chains and a number of intermediate and light chains.

Subcellular location: Cytoplasm › cytoskeleton › cilium axoneme

Potential.

Tissue specificity: Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung. Ref.5

Domain: Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function

By similarity.

Sequence similarities: Belongs to the dynein heavy chain family.Contains 5 TPR repeats.

RNA editing: Modified position: not applicable.Exon 13 included in isoform 3 is extensively edited in brain. Ref.6

Sequence caution: The sequence AK128517 differs from that shown. Reason: Frameshift at position 3963. The sequence BAA96027.2 differs from that shown. Reason: Erroneous initiation.