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DPT Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS627786

DPT is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. This protein is found in various tissues and many of its tyrosine residues are sulphated. The protein is postulated to modify the behavior of… More details

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Product Overview

Online Datasheet in PDF
Product Name
DPT, Polyclonal Antibody
Full Product Name
DPT, ID (Dermatopontin, Tyrosine-rich Acidic Matrix Protein, TRAMP)
Product Gene Name
anti-DPT antibody
Product Synonym Names
Anti -DPT, ID (Dermatopontin, Tyrosine-rich Acidic Matrix Protein, TRAMP)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human DPT.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
24,005 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (168664695..168698442, complement). Location: 1q12-q23
OMIM
125597
3D Structure
ModBase 3D Structure for Q07507
Immunogen
Synthetic peptide selected from the Center region of human DPT (KLH).

Product Categories/Family for anti-DPT antibody

Antibodies; Abs to Extracellular Matrix Proteins
Applications Tested/Suitable for anti-DPT antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-DPT antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-DPT antibody

Western blot analysis of DPT antibody (Center) in HL60 cell line lysates (35ug/lane). DPT (arrow) was detected using the purified Pab.
Rabbit Anti-DPT Polyclonal Antibody – Cat# MBS627786

Immunohistochemistry (IHC) of anti-DPT antibody

Formalin-fixed and paraffin-embedded human brain with DPT Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-DPT Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS627786

Flow Cytometry (FC/FACS) of anti-DPT antibody

Flow cytometric analysis of NCI-H292 cells using DPT Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-DPT Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS627786

Immunofluorescence (IF) of anti-DPT antibody

Immunofluorescence analysis of DPT Antibody (Center) with paraffin-embedded human brain tissue . 0.05 mg/ml primary antibody was followed by FITC-conjugated goat anti-rabbit lgG (whole molecule). FITC emits green fluorescence.Red counterstaining is PI.
Rabbit Anti-DPT Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS627786

Other Notes

Small volumes of anti-DPT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DPT purchase

MBS627786 is an antibody targeting DPT. Also known as DPT, ID (Dermatopontin, Tyrosine-rich Acidic Matrix Protein, TRAMP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DPT. It may not necessarily be applicable to this product.

NCBI GI #
32307172
NCBI GeneID
1805
NCBI Accession #
NP_001928.2
UniProt Primary Accession #
Q07507
UniProt Secondary Accession #
Q8N4R2; Q9UIX8; A8K981
UniProt Related Accession #
Q07507
GenBank Nucleotide #
NM_001937.4
NCBI Official Full Name
dermatopontin
NCBI Official Synonym Full Names
dermatopontin
NCBI Official Symbol
DPT
NCBI Official Synonym Symbols
TRAMP
UniProt Protein Name
Dermatopontin
UniProt Synonym Protein Names
Tyrosine-rich acidic matrix protein
Protein Family
Dermatopontin
UniProt Gene Name
DPT
UniProt Synonym Gene Names
TRAMP
UniProt Entry Name
DERM_HUMAN
NCBI Protein Information
dermatopontin; tyrosine-rich acidic matrix protein

NCBI Summary for DPT

Dermatopontin is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. The protein is found in various tissues and many of its tyrosine residues are sulphated. Dermatopontin is postulated to modify the behavior of TGF-beta through interaction with decorin. [provided by RefSeq, Jul 2008]
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UniProt Comments for DPT

DPT: Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation. Belongs to the dermatopontin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q12-q23

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space

Biological Process: negative regulation of cell proliferation; collagen fibril organization; cell adhesion
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Research Articles on DPT

1. data provided strong evidence that downregulation of DPT is a characteristic event in human oral squamous cell carcinoma and that DPT was correlated with cellular adhesion and invasiveness.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DPT antibody

 Reference Product  PubMed Publications
 TGFB1 antibody  >5 publications with DPT and TGFB1
 TLR4 antibody  >4 publications with DPT and TLR4
 DCN antibody  >3 publications with DPT and DCN
 AHR antibody  >2 publications with DPT and AHR
 IL4 antibody  >2 publications with DPT and IL4

Diseases associated with anti-DPT antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >241 publications with DPT and Nervous System Diseases
 Neoplasms Antibodies  >159 publications with DPT and Neoplasms
 Liver Diseases Antibodies  >63 publications with DPT and Liver Diseases
 Inflammation Antibodies  >56 publications with DPT and Inflammation
 Heart Diseases Antibodies  >51 publications with DPT and Heart Diseases
 Congenital Abnormalities Antibodies  >36 publications with DPT and Congenital Abnormalities
 Kidney Diseases Antibodies  >36 publications with DPT and Kidney Diseases
 Edema Antibodies  >28 publications with DPT and Edema
 Necrosis Antibodies  >27 publications with DPT and Necrosis
 Adenocarcinoma Antibodies  >26 publications with DPT and Adenocarcinoma

Organs/Tissues associated with anti-DPT antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >139 publications with DPT and Eye
 Brain Antibodies  >131 publications with DPT and Brain
 Skin Antibodies  >112 publications with DPT and Skin
 Bone Antibodies  >92 publications with DPT and Bone
 Muscle Antibodies  >79 publications with DPT and Muscle
 Liver Antibodies  >74 publications with DPT and Liver
 Mouth Antibodies  >66 publications with DPT and Mouth
 Heart Antibodies  >62 publications with DPT and Heart
 Lung Antibodies  >58 publications with DPT and Lung
 Nerve Antibodies  >54 publications with DPT and Nerve
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