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DSTN Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6001922

DSTN belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This protein encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin… More details

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Product Overview

Online Datasheet in PDF
Product Name
DSTN, Polyclonal Antibody
Full Product Name
DSTN, ID (DSTN, ACTDP, DSN, Destrin, Actin-depolymerizing factor)
Product Gene Name
anti-DSTN antibody
Product Synonym Names
Anti -DSTN, ID (DSTN, ACTDP, DSN, Destrin, Actin-depolymerizing factor)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
18,506 Da
Chromosome Location
Chromosome: 20; NC_000020.10 (17549818..17588887). Location: 20p12.1
OMIM
609114
3D Structure
ModBase 3D Structure for P60981
Immunogen
DSTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77~106 amino acids from the Center region of human DSTN.

Product Categories/Family for anti-DSTN antibody

Antibodies; Abs to Actin Related Proteins
Applications Tested/Suitable for anti-DSTN antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-DSTN antibody
Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
Flow Cytometry: 1:10-50

Western Blot (WB) of anti-DSTN antibody

Western blot analysis of DSTN Antibody (Center) in MCF-7 cell line lysates (35ug/lane). DSTN (arrow) was detected using the purified Pab.
Rabbit Anti-DSTN Polyclonal Antibody – Cat# MBS6001922

Immunohistochemistry (IHC) of anti-DSTN antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with DSTN Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-DSTN Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6001922

Flow Cytometry (FC/FACS) of anti-DSTN antibody

DSTN Antibody (Center) flow cytometry analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-DSTN Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6001922

Western Blot (WB) of anti-DSTN antibody

Western blot analysis of DSTN (arrow) using rabbit polyclonal DSTN Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the DSTN gene.
Rabbit Anti-DSTN Polyclonal Antibody, Western Blot (WB) – Cat# MBS6001922

Other Notes

Small volumes of anti-DSTN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DSTN purchase

MBS6001922 is an antibody targeting DSTN. Also known as DSTN, ID (DSTN, ACTDP, DSN, Destrin, Actin-depolymerizing factor). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DSTN. It may not necessarily be applicable to this product.

NCBI GI #
49456867
NCBI GeneID
11034
NCBI Accession #
CAG46754.1
UniProt Primary Accession #
P60981
UniProt Secondary Accession #
P18282; Q5W166; Q6IAW2; B2R6N2; B4DYA6
UniProt Related Accession #
P60981
NCBI Official Full Name
DSTN
NCBI Official Synonym Full Names
destrin (actin depolymerizing factor)
NCBI Official Symbol
DSTN
NCBI Official Synonym Symbols
ADF; ACTDP; bA462D18.2
UniProt Protein Name
Destrin
UniProt Synonym Protein Names
Actin-depolymerizing factor
Protein Family
Destrin
UniProt Gene Name
DSTN
UniProt Synonym Gene Names
ACTDP; DSN; ADF
UniProt Entry Name
DEST_HUMAN
NCBI Protein Information
destrin; actin-depolymerizing factor; bA462D18.2 (destrin (actin depolymerizing factor ADF) (ACTDP))

NCBI Summary for DSTN

The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for DSTN

Destrin: an actin-depolymerizing cytoskeletal protein that belongs to the ADF actin-binding protein family. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Present in many vertebrate tissues and particularly abundant in neuronal cells. It binds F-actin in a pH-dependent manner which affects it's severing/depolymerizing activities. It also binds G-actin at pH 8.0 thereby sequestering monomers and preventing polymerization.

Protein type: Motility/polarity/chemotaxis; Actin-binding

Chromosomal Location of Human Ortholog: 20p12.1

Cellular Component: cortical actin cytoskeleton; actin cytoskeleton

Molecular Function: actin binding

Biological Process: actin filament depolymerization; actin filament severing; positive regulation of actin filament depolymerization; actin polymerization and/or depolymerization
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Research Articles on DSTN

1. Destrin is upregulated in nerve-invasive pancreatic cancer cells and its expression might be related to perineural invasiveness

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DSTN antibody

 Reference Product  PubMed Publications
 SSH1 antibody  >2 publications with DSTN and SSH1

Pathways associated with anti-DSTN antibody

 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram

Diseases associated with anti-DSTN antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >8 publications with DSTN and Neoplasms
 Inflammation Antibodies  >6 publications with DSTN and Inflammation
 Congenital Abnormalities Antibodies  >4 publications with DSTN and Congenital Abnormalities
 Prostatic Neoplasms Antibodies  >2 publications with DSTN and Prostatic Neoplasms
 Prostatic Diseases Antibodies  >2 publications with DSTN and Prostatic Diseases
 Kidney Diseases Antibodies  >2 publications with DSTN and Kidney Diseases
 Disease Models, Animal Antibodies  >2 publications with DSTN and Disease Models, Animal
 Glioblastoma Antibodies  >1 publications with DSTN and Glioblastoma
 Cardiovascular Diseases Antibodies  >1 publications with DSTN and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >1 publications with DSTN and Neoplasms, Experimental

Organs/Tissues associated with anti-DSTN antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11 publications with DSTN and Brain
 Eye Antibodies  >6 publications with DSTN and Eye
 Kidney Antibodies  >4 publications with DSTN and Kidney
 Embryonic Tissue Antibodies  >4 publications with DSTN and Embryonic Tissue
 Testis Antibodies  >3 publications with DSTN and Testis
 Bone Antibodies  >2 publications with DSTN and Bone
 Prostate Antibodies  >2 publications with DSTN and Prostate
 Skin Antibodies  >1 publications with DSTN and Skin
 Vascular Antibodies  >1 publications with DSTN and Vascular
 Stomach Antibodies  >1 publications with DSTN and Stomach
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