DTX1 Antibody – Rabbit Polyclonal

DTX1: Functions as an ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T- cell development, suggesting that it can antagonize NOTCH1. Belongs to the Deltex family.

Protein type: Ubiquitin ligase; Ubiquitin conjugating system; Ligase; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 12q24.13

Cellular Component: cytoplasm; nucleus; cytosol

Molecular Function: protein binding; zinc ion binding; ubiquitin protein ligase binding; transcription coactivator activity; Notch binding; SH3 domain binding; ligase activity

Biological Process: transcription from RNA polymerase II promoter; negative regulation of neuron differentiation; Notch signaling pathway; glial cell differentiation; cell surface receptor linked signal transduction; regulation of Notch signaling pathway; transcription, DNA-dependent; protein ubiquitination; negative regulation of T cell differentiation