• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

DUSP4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6376722

DUSP4 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the… More details

$1040 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DUSP4, Polyclonal Antibody
Full Product Name
DUSP4 (Dual Specificity Protein Phosphatase 4, Dual Specificity Protein Phosphatase hVH2, HVH2, Mitogen-activated Protein Kinase Phosphatase 2, MAP Kinase Phosphatase 2, MKP2, MKP-2, TYP, VH2) (AP)
Product Gene Name
anti-DUSP4 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human DUSP4.
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
32,993 Da
Immunogen
Full length human DUSP4, aa1-394 (NP_001385.1).
Immunogen Sequence
MVTMEELREMDCSVLKRLMNRDENGGGAGGSGSHGTLGLPSGGKCLLLDCRPFLAHSAGYILGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLREDSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLDLGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATPTSQFVFSFPVSVGVHSAPSSLPYLHSPITTSPSC
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-DUSP4 antibody

Antibodies; Enzymes; Phosphatase
Applications Tested/Suitable for anti-DUSP4 antibody
Western Blot (WB)
Application Notes for anti-DUSP4 antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-DUSP4 antibody

Western Blot analysis of DUSP4 expression in transfected 293T cell line by DUSP4 polyclonal antibody. Lane 1: DUSP4 transfected lysate (43kD). Lane 2: Non-transfected lysate.
Rabbit Anti-DUSP4 Polyclonal Antibody – Cat# MBS6376722

Testing Data of anti-DUSP4 antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between DUSP4 and MAPK9 HeLa cells were stained with DUSP4 rabbit purified polyclonal 1:1200 and MAPK9 mouse monoclonal antibody 1:50. Signals were detected by 30 Detection Kit 613 (red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex
Rabbit Anti-DUSP4 Polyclonal Antibody, Testing Data – Cat# MBS6376722

Other Notes

Small volumes of anti-DUSP4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DUSP4 purchase

MBS6376722 is an antibody targeting DUSP4. Also known as DUSP4 (Dual Specificity Protein Phosphatase 4, Dual Specificity Protein Phosphatase hVH2, HVH2, Mitogen-activated Protein Kinase Phosphatase 2, MAP Kinase Phosphatase 2, MKP2, MKP-2, TYP, VH2) (AP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DUSP4. It may not necessarily be applicable to this product.

NCBI GI #
325651887
NCBI GeneID
1846
NCBI Accession #
NP_001385.1
UniProt Secondary Accession #
Q13524; B2RBU5; D3DSU4; G5E930
UniProt Related Accession #
Q13115
GenBank Nucleotide #
NM_001394
NCBI Official Full Name
Homo sapiens dual specificity phosphatase 4 (DUSP4), transcript variant 1, mRNA
NCBI Official Synonym Full Names
dual specificity phosphatase 4
NCBI Official Symbol
DUSP4
NCBI Official Synonym Symbols
TYP; HVH2; MKP2; MKP-2
Protein Family
Dual specificity protein phosphatase
NCBI Protein Information
dual specificity protein phosphatase 4; MAP kinase phosphatase 2; VH1 homologous phosphatase 2; dual specificity protein phosphatase hVH2; mitogen-activated protein kinase phosphatase 2; serine/threonine specific protein phosphatase

NCBI Summary for DUSP4

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008]
Show more

Research Articles on DUSP4

1. Data suggest that MKP-2 rather than MKP-1 is tamoxifen-regulated and that the elevated expression of MKP-2 in MCF7-TAMR cells potentially functions to restore tamoxifen sensitivity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DUSP4 antibody

 Reference Product  PubMed Publications
 MAPK1 antibody  >17 publications with DUSP4 and MAPK1
 MAPK3 antibody  >12 publications with DUSP4 and MAPK3
 EGR1 antibody  >5 publications with DUSP4 and EGR1
 MAPK8 antibody  >4 publications with DUSP4 and MAPK8
 HOXA10 antibody  >3 publications with DUSP4 and HOXA10
 MAPK14 antibody  >2 publications with DUSP4 and MAPK14

Pathways associated with anti-DUSP4 antibody

 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 ERK/MAPK Targets Pathway antibodies  ERK/MAPK Targets Pathway Diagram
 ERKs Are Inactivated Pathway antibodies  ERKs Are Inactivated Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 MAP Kinase Activation In TLR Cascade Pathway antibodies  MAP Kinase Activation In TLR Cascade Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram

Diseases associated with anti-DUSP4 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >11 publications with DUSP4 and Carcinoma
 Necrosis Antibodies  >9 publications with DUSP4 and Necrosis
 Breast Neoplasms Antibodies  >7 publications with DUSP4 and Breast Neoplasms
 Inflammation Antibodies  >5 publications with DUSP4 and Inflammation
 Lung Neoplasms Antibodies  >4 publications with DUSP4 and Lung Neoplasms
 Heart Diseases Antibodies  >4 publications with DUSP4 and Heart Diseases
 Disease Models, Animal Antibodies  >4 publications with DUSP4 and Disease Models, Animal
 Liver Diseases Antibodies  >3 publications with DUSP4 and Liver Diseases
 Lung Diseases Antibodies  >3 publications with DUSP4 and Lung Diseases
 Liver Neoplasms Antibodies  >3 publications with DUSP4 and Liver Neoplasms

Organs/Tissues associated with anti-DUSP4 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11 publications with DUSP4 and Brain
 Blood Antibodies  >9 publications with DUSP4 and Blood
 Vascular Antibodies  >7 publications with DUSP4 and Vascular
 Heart Antibodies  >6 publications with DUSP4 and Heart
 Bone Antibodies  >5 publications with DUSP4 and Bone
 Lung Antibodies  >4 publications with DUSP4 and Lung
 Liver Antibodies  >3 publications with DUSP4 and Liver
 Intestine Antibodies  >3 publications with DUSP4 and Intestine
 Embryonic Tissue Antibodies  >3 publications with DUSP4 and Embryonic Tissue
 Kidney Antibodies  >2 publications with DUSP4 and Kidney
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000