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DZIP3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8242390

MBS8242390 is an antibody targeting DZIP3. Reactive in Human. Host: Rabbit. Rabbit polyclonal antibody to DZIP3 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DZIP3, Polyclonal Antibody
Full Product Name
Anti-DZIP3 Antibody
Product Gene Name
anti-DZIP3 antibody
Product Synonym Names
KIAA0675; E3 ubiquitin-protein ligase DZIP3; DAZ-interacting protein 3; RNA-binding ubiquitin ligase of 138 kDa; hRUL138
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid in PBS, pH 7.3, 0.2% BSA, and 0.02% Sodium Azide.
Purity/Purification
The antibody was purified by affinity chromatography.
Specificity
Recognizes endogenous levels of DZIP3 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
DZIP3 peptide (MBS8243480) is used for blocking the activity of DZIP3 antibody (MBS8242390)
Molecular Weight
35,240 Da
OMIM
608672
3D Structure
ModBase 3D Structure for Q86Y13
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human DZIP3. The exact sequence is proprietary.
Applications Tested/Suitable for anti-DZIP3 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-DZIP3 antibody
Western Blot: (1/500 - 1/1000); Immunohistochemistry: (1/100 - 1/200)

Western Blot (WB) of anti-DZIP3 antibody

Western blot analysis of DZIP3 expression in HEK293T (A), A431 (B) whole cell lysates.
Rabbit Anti-DZIP3 Polyclonal Antibody – Cat# MBS8242390

Immunohistochemistry (IHC) of anti-DZIP3 antibody

Immunohistochemical analysis of DZIP3 staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Rabbit Anti-DZIP3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS8242390

Other Notes

Small volumes of anti-DZIP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DZIP3. It may not necessarily be applicable to this product.

NCBI GI #
50400482
NCBI GeneID
9666
NCBI Accession #
Q86Y13.2
UniProt Primary Accession #
Q86Y13
UniProt Secondary Accession #
O75162; Q6P3R9; Q6PH82; Q86Y14; Q86Y15; Q86Y16; Q8IWI0; Q96RS9; B3KN01
UniProt Related Accession #
Q86Y13
NCBI Official Full Name
E3 ubiquitin-protein ligase DZIP3
NCBI Official Synonym Full Names
DAZ interacting zinc finger protein 3
NCBI Official Symbol
DZIP3
NCBI Official Synonym Symbols
UURF2; PPP1R66; hRUL138
UniProt Protein Name
E3 ubiquitin-protein ligase DZIP3
UniProt Synonym Protein Names
DAZ-interacting protein 3; RNA-binding ubiquitin ligase of 138 kDa; hRUL138
Protein Family
E3 ubiquitin-protein ligase
UniProt Gene Name
DZIP3
UniProt Synonym Gene Names
KIAA0675; hRUL138
UniProt Entry Name
DZIP3_HUMAN
NCBI Protein Information
E3 ubiquitin-protein ligase DZIP3

UniProt Comments for DZIP3

DZIP3: E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.19; Ligase; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 3q13.13

Cellular Component: cytoplasm

Molecular Function: ligase activity; phosphatase binding; polyubiquitin binding; protein binding; RNA binding; ubiquitin-protein ligase activity; zinc ion binding

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process
Show more

Research Articles on DZIP3

1. By monoubiquitination of H2A at lysine 119, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TLR activation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-DZIP3 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram

Organs/Tissues associated with anti-DZIP3 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >1 publications with DZIP3 and Nerve
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