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E2F8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9451600

This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper… More details

$435 / 0.1 mL (Biotin) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
E2F8, Polyclonal Antibody
Full Product Name
E2F8 Conjugated Antibody
Product Gene Name
anti-E2F8 antibody
Product Synonym Names
E2F-8
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
Specificity
The antibody detects endogenous levels of total E2F8 protein.
Preparation and Storage
Store at 4 degree C for 6 months.
Molecular Weight
94kDa
OMIM
612047
3D Structure
ModBase 3D Structure for A0AVK6
Immunogen
Synthetic peptide of human E2F8
Conjugation
Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
Excitation Emission
AF350: 346nm/442nm
Applications Tested/Suitable for anti-E2F8 antibody
Most Applications
Application Notes for anti-E2F8 antibody
Suggested Dilution:
AF350 conjugated: most applications: 1:50-1:250
AF405 conjugated: most applications: 1:50-1:250
AF488 conjugated: most applications: 1:50-1:250
AF555 conjugated: most applications: 1:50-1:250
AF594 conjugated: most applications: 1:50-1:250
AF647 conjugated: most applications: 1:50-1:250
AF680 conjugated: most applications: 1:50-1:250
AF750 conjugated: most applications: 1:50-1:250
Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000

Other Notes

Small volumes of anti-E2F8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for E2F8 purchase

MBS9451600 is an antibody targeting E2F8. Also known as E2F8 Conjugated Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for E2F8. It may not necessarily be applicable to this product.

NCBI GI #
121949436
NCBI GeneID
79733
NCBI Accession #
NP_078956
UniProt Primary Accession #
A0AVK6
UniProt Related Accession #
A0AVK6
GenBank Nucleotide #
NM_024680
NCBI Official Full Name
Transcription factor E2F8
NCBI Official Synonym Full Names
E2F transcription factor 8
NCBI Official Symbol
E2F8
NCBI Official Synonym Symbols
E2F-8
UniProt Protein Name
Transcription factor E2F8
Protein Family
Transcription factor
UniProt Gene Name
E2F8
UniProt Synonym Gene Names
E2F-8
UniProt Entry Name
E2F8_HUMAN
NCBI Protein Information
transcription factor E2F8

UniProt Comments for E2F8

E2F8: Along with E2F7, inhibitor of E2F-dependent transcription. Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Directly represses E2F1 transcription. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession. Belongs to the E2F/DP family.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: transcription factor complex; nucleus

Molecular Function: protein binding; protein homodimerization activity; transcription corepressor activity; transcription factor activity

Biological Process: cell proliferation; transcription, DNA-dependent; positive regulation of DNA endoreduplication; positive regulation of transcription from RNA polymerase II promoter; sprouting angiogenesis; cell cycle comprising mitosis without cytokinesis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cytokinesis; placenta development
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Research Articles on E2F8

1. miR-223-5p suppressed NSCLC progression through targeting E2F8.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-E2F8 antibody

 Reference Product  PubMed Publications
 E2F7 antibody  >20 publications with E2F8 and E2F7
 TP53 antibody  >2 publications with E2F8 and TP53

Diseases associated with anti-E2F8 antibody

 Disease Name  Pubmed Publications
 Carcinoma, Hepatocellular Antibodies  >4 publications with E2F8 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >4 publications with E2F8 and Liver Diseases
 Adenocarcinoma Antibodies  >4 publications with E2F8 and Adenocarcinoma
 Liver Neoplasms Antibodies  >3 publications with E2F8 and Liver Neoplasms
 Carcinoma, Squamous Cell Antibodies  >1 publications with E2F8 and Carcinoma, Squamous Cell
 Neoplasms, Experimental Antibodies  >1 publications with E2F8 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >1 publications with E2F8 and Disease Models, Animal

Organs/Tissues associated with anti-E2F8 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >5 publications with E2F8 and Embryonic Tissue
 Lung Antibodies  >1 publications with E2F8 and Lung
 Uterus Antibodies  >1 publications with E2F8 and Uterus
 Placenta Antibodies  >1 publications with E2F8 and Placenta
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