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PA2G4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS627493

PA2G4 is an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This… More details

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Product Overview

Online Datasheet in PDF
Product Name
EBP1 (PA2G4), Polyclonal Antibody
Full Product Name
EBP1, ID (Proliferation-associated Protein 2G4, Cell Cycle Protein p38-2G4 Homolog, hG4-1, ErbB3-binding Protein 1, PA2G4, EBP1)
Product Gene Name
anti-PA2G4 antibody
Product Synonym Names
Anti -EBP1, ID (Proliferation-associated Protein 2G4, Cell Cycle Protein p38-2G4 Homolog, hG4-1, ErbB3-binding Protein 1, PA2G4, EBP1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human EBP1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
45,151 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (56498103..56507694). Location: 12q13.2
3D Structure
ModBase 3D Structure for Q05D08
Immunogen
Synthetic peptide selected from the Center region of human EBP1 (KLH).

Product Categories/Family for anti-PA2G4 antibody

Antibodies; Abs to Binding Proteins
Applications Tested/Suitable for anti-PA2G4 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-PA2G4 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-PA2G4 antibody

EBP1 Antibody (Center) western blot analysis in A2058,Jurkat,MCF-7 cell line lysates (35ug/lane).This demonstrates the EBP1 antibody detected the EBP1 protein (arrow).
Rabbit Anti-PA2G4 Polyclonal Antibody – Cat# MBS627493

Immunohistochemistry (IHC) of anti-PA2G4 antibody

EBP1 Antibody (Center) IHC analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the EBP1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-PA2G4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS627493

Flow Cytometry (FC/FACS) of anti-PA2G4 antibody

EBP1 Antibody (Center) flow cytometric analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-PA2G4 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS627493

Other Notes

Small volumes of anti-PA2G4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PA2G4 purchase

MBS627493 is an antibody targeting PA2G4. Also known as EBP1, ID (Proliferation-associated Protein 2G4, Cell Cycle Protein p38-2G4 Homolog, hG4-1, ErbB3-binding Protein 1, PA2G4, EBP1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PA2G4. It may not necessarily be applicable to this product.

NCBI GI #
4099506
NCBI GeneID
5036
UniProt Primary Accession #
Q05D08
UniProt Related Accession #
Q05D08; Q13548; Q6PIN5; Q9UQ80
NCBI Official Full Name
erbB3 binding protein EBP1
NCBI Official Synonym Full Names
proliferation-associated 2G4, 38kDa
NCBI Official Symbol
PA2G4
NCBI Official Synonym Symbols
EBP1; HG4-1; p38-2G4
UniProt Protein Name
PA2G4 protein
Protein Family
Proliferation-associated protein
UniProt Gene Name
PA2G4
UniProt Entry Name
Q05D08_HUMAN
NCBI Protein Information
proliferation-associated protein 2G4; erbB3-binding protein 1; ErbB-3 binding protein 1; ErbB3-binding protein Ebp1; cell cycle protein p38-2G4 homolog

NCBI Summary for PA2G4

This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq]
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UniProt Comments for PA2G4

Ebp1: May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site). Belongs to the peptidase M24 family.

Protein type: Nucleolus; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 12q13.2

Cellular Component: nucleoplasm; membrane; cytoplasm; nucleolus; nucleus; ribonucleoprotein complex

Molecular Function: protein binding; DNA binding; ubiquitin protein ligase binding; transcription factor activity

Biological Process: regulation of translation; cell proliferation; transcription, DNA-dependent; cell cycle arrest; positive regulation of cell differentiation; negative regulation of transcription, DNA-dependent; rRNA processing; negative regulation of apoptosis
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Research Articles on PA2G4

1. Ablation of EBP1 expression led to tamoxifen resistance in breast cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PA2G4 antibody

 Reference Product  PubMed Publications
 ERBB3 antibody  >21 publications with PA2G4 and ERBB3
 HDAC2 antibody  >4 publications with PA2G4 and HDAC2
 SIN3A antibody  >1 publications with PA2G4 and SIN3A

Pathways associated with anti-PA2G4 antibody

 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram

Diseases associated with anti-PA2G4 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >20 publications with PA2G4 and Neoplasms
 Breast Neoplasms Antibodies  >8 publications with PA2G4 and Breast Neoplasms
 Skin Diseases Antibodies  >6 publications with PA2G4 and Skin Diseases
 Carcinoma Antibodies  >5 publications with PA2G4 and Carcinoma
 Prostatic Neoplasms Antibodies  >4 publications with PA2G4 and Prostatic Neoplasms
 Colorectal Neoplasms Antibodies  >3 publications with PA2G4 and Colorectal Neoplasms
 Intestinal Diseases Antibodies  >3 publications with PA2G4 and Intestinal Diseases
 Leukemia Antibodies  >2 publications with PA2G4 and Leukemia
 Mouth Neoplasms Antibodies  >2 publications with PA2G4 and Mouth Neoplasms
 Head and Neck Neoplasms Antibodies  >2 publications with PA2G4 and Head and Neck Neoplasms

Organs/Tissues associated with anti-PA2G4 antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >10 publications with PA2G4 and Prostate
 Blood Antibodies  >4 publications with PA2G4 and Blood
 Brain Antibodies  >2 publications with PA2G4 and Brain
 Ovary Antibodies  >1 publications with PA2G4 and Ovary
 Ascites Antibodies  >1 publications with PA2G4 and Ascites
 Pancreas Antibodies  >1 publications with PA2G4 and Pancreas
 Muscle Antibodies  >1 publications with PA2G4 and Muscle
 Mammary Gland Antibodies  >1 publications with PA2G4 and Mammary Gland
 Intestine Antibodies  >1 publications with PA2G4 and Intestine
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