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ELP3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6377303

Elongator complex protein 3 (ELP3) is a catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ELP3, Polyclonal Antibody
Full Product Name
ELP3 (Elongator Complex Protein 3, hELP3, FLJ10422) (MaxLight 750)
Product Gene Name
anti-ELP3 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human ELP3.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
52,202 Da
OMIM
612722
3D Structure
ModBase 3D Structure for Q9H9T3
Immunogen
Full length human ELP3, aa1-547 (NP_060561.3).
Immunogen Sequence
MRQKRKGDLSPAELMMLTIGDVIKQLIEAHEQGKDIDLNKVKTKTAAKYGLSAQPRLVDIIAAVPPQYRKVLMPKLKAKPIRTASGIAVVAVMCKPHRCPHISFTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPFLQTRHRIEQLKQLGHSVDKVEFIVMGGTFMALPEEYRDYFIRNLHDALSGHTSNNIYEAVKYSERSLTKCIGITIETRPDYCMKRHLSDMLTYGCTRLEIGVQSVYEDVARDTNRGHTVKAVCESFHLAKDSGFKVVAHMMPDLPNVGLERDIEQFTEFFENPAFRPDGLKLYPTLVIRGTGLYELWKSGRYKSYSPSDLVELVARILALVPPWTRVYRVQRDIPMPLVSSGVEHGNLRELALARMKDLGIQCRDVRTREVGIQEIHHKVRPYQVELVRRDYVANGGWETFLSYEDPDQDILIGLLRLRKCSEETFRFELGGGVSIVRELHVYGSVVPVSSRDPTKFQHQGFGMLLMEEAERIAREEHGSGKIAVISGVGTRNYYRKIGYRLQGPYMVKMLK
Conjugate
MaxLight750
Note
Preservative Free

Product Categories/Family for anti-ELP3 antibody

Antibodies; Proteins
Applications Tested/Suitable for anti-ELP3 antibody
Western Blot (WB)
Application Notes for anti-ELP3 antibody
Applications are based on unconjugated antibody.

Other Notes

Small volumes of anti-ELP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ELP3 purchase

MBS6377303 is an antibody targeting ELP3. Also known as ELP3 (Elongator Complex Protein 3, hELP3, FLJ10422) (MaxLight 750). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ELP3. It may not necessarily be applicable to this product.

NCBI GI #
23510283
NCBI GeneID
55140
NCBI Accession #
NP_060561.3
UniProt Primary Accession #
Q9H9T3
UniProt Secondary Accession #
Q53G84; Q6AWB0; Q9BVF7; Q9NVZ1; B4DE19; B4DIG1; E2QRI5
UniProt Related Accession #
Q9H9T3
GenBank Nucleotide #
NM_018091.3
NCBI Official Full Name
elongator complex protein 3 isoform 1
NCBI Official Synonym Full Names
elongator acetyltransferase complex subunit 3
NCBI Official Symbol
ELP3
NCBI Official Synonym Symbols
KAT9
UniProt Protein Name
Elongator complex protein 3
Protein Family
Elongator complex protein
UniProt Gene Name
ELP3
UniProt Synonym Gene Names
hELP3
UniProt Entry Name
ELP3_HUMAN
NCBI Protein Information
elongator complex protein 3; elongation protein 3 homolog

NCBI Summary for ELP3

ELP3 is the catalytic subunit of the histone acetyltransferase elongator complex, which contributes to transcript elongation and also regulates the maturation of projection neurons (Creppe et al., 2009 [PubMed 19185337]).[supplied by OMIM, Apr 2009]

UniProt Comments for ELP3

ELP3: a histone acetyltransferase. A subunit of the Elongator complex, which associates with the elongating, hyperphosphorylated form of RNA polymerase II.

Protein type: EC 2.3.1.48; Acetyltransferase

Chromosomal Location of Human Ortholog: 8p21.1

Cellular Component: transcription elongation factor complex; Elongator holoenzyme complex; cytoplasm; nucleolus; histone acetyltransferase complex

Molecular Function: protein binding; H4 histone acetyltransferase activity; metal ion binding; iron-sulfur cluster binding; phosphorylase kinase regulator activity; H3 histone acetyltransferase activity

Biological Process: tRNA wobble uridine modification; regulation of transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; central nervous system development; RNA elongation from RNA polymerase II promoter; neuron migration; regulation of protein kinase activity; positive regulation of cell migration
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Research Articles on ELP3

1. Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ELP3 antibody

 Reference Product  PubMed Publications
 ELP2 antibody  >11 publications with ELP3 and ELP2
 ELP4 antibody  >10 publications with ELP3 and ELP4
 IKBKAP antibody  >3 publications with ELP3 and IKBKAP
 PAF1 antibody  >1 publications with ELP3 and PAF1

Pathways associated with anti-ELP3 antibody

 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 HATs Acetylate Histones Pathway antibodies  HATs Acetylate Histones Pathway Diagram

Diseases associated with anti-ELP3 antibody

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >2 publications with ELP3 and Mental Disorders
 Disease Models, Animal Antibodies  >2 publications with ELP3 and Disease Models, Animal
 Atrophy Antibodies  >1 publications with ELP3 and Atrophy

Organs/Tissues associated with anti-ELP3 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >22 publications with ELP3 and Nerve
 Brain Antibodies  >5 publications with ELP3 and Brain
 Embryonic Tissue Antibodies  >4 publications with ELP3 and Embryonic Tissue
 Lymph Antibodies  >2 publications with ELP3 and Lymph
 Kidney Antibodies  >2 publications with ELP3 and Kidney
 Lymph Node Antibodies  >2 publications with ELP3 and Lymph Node
 Liver Antibodies  >1 publications with ELP3 and Liver
 Vascular Antibodies  >1 publications with ELP3 and Vascular
 Uterus Antibodies  >1 publications with ELP3 and Uterus
 Testis Antibodies  >1 publications with ELP3 and Testis
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